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Research Areas
- Estrogen and related hormone effects
- Mechanisms of cancer metastasis
- Reproductive Biology and Fertility
A major aging hallmark is the accumulation of cellular senescence burden. Over time senescent cells contribute to tissue deterioration through chronic inflammation and fibrosis driven by Senescence-Associated Secretory Phenotype (SASP). The human ovary one first organs age, prominent age-related fibroinflammation within ovarian microenvironment consistent with presence cells, but these have not been characterized in ovary. We thus established a doxorubicin-induced model establish senotype...
10.1101/2024.10.02.616143
preprint
EN
bioRxiv (Cold Spring Harbor Laboratory)
2024-10-02
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