A5103324261- Ultrasound and Hyperthermia Applications
- Photoacoustic and Ultrasonic Imaging
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Ultrasound Imaging and Elastography
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Migraine and Headache Studies
- Optical Imaging and Spectroscopy Techniques
- Neurological disorders and treatments
- Pain Management and Treatment
- Neural dynamics and brain function
- Nerve Injury and Rehabilitation
- Cerebral Palsy and Movement Disorders
- Vagus Nerve Stimulation Research
Medical University of Vienna
2013-2022
TU Wien
2018
Ultrasound-based brain stimulation techniques may become a powerful new technique to modulate the human in focal and targeted manner. However, for clinical no certified systems exist current have be further developed. Here, sonication is introduced, based on single ultrashort ultrasound pulses (transcranial pulse stimulation, TPS) which markedly differs from existing focused techniques. In addition, first study using observations of long term effects are presented. Comprehensive feasibility,...
Abstract Background With the high spatial resolution and potential to reach deep brain structures, ultrasound-based stimulation techniques offer new opportunities non-invasively treat neurological psychiatric disorders. However, little is known about long-term effects of stimulation. Applying a longitudinal design, we comprehensively investigated neuromodulation induced by ultrasound provide first sham-controlled evidence on human behavior. Methods Twelve healthy participants received three...
Functional imaging of the brainstem may open new avenues for clinical diagnostics. However, reliable assessments activation, further efforts improving signal quality are needed. Six healthy subjects performed four repeated functional magnetic resonance (fMRI) sessions on different days with jaw clenching as a motor task to elicit activation in trigeminal nucleus. images were acquired 7 T MR scanner using an optimized multiband EPI sequence. Activation measures nucleus and control region...
Cortical reorganization in response to peripheral nervous system damage is only poorly understood. In patients with complete brachial plexus avulsion and subsequent reconnection of the end musculocutaneous nerve side a phrenic nerve, leads doubled arm representation primary motor cortex. Despite homuncular organization being one most fundamental principles human brain, movements affected now activate 2 loci: completely denervated diaphragm representation. Here we investigate details behind...
Abstract Ultrasound-based brain stimulation techniques offer an exciting potential to modulate the human in a highly focal and precisely targeted manner. However, for clinical applications current have be further developed. We introduce new ultrasound technique, based on single ultrashort pulses (transcranial pulse stimulation, TPS) describe first navigable TPS system. Feasibility, safety preliminary (uncontrolled) efficacy data Alzheimer’s disease (AD) are provided. Simulation data, vitro...
In article number 1902583, Roland Beisteiner and co-workers describe a brain activation technique for treatment of Alzheimer's disease. Transcranial pulse stimulation (TPS) applies ultrashort ultrasound pulses to activate neuronal resources. A therapeutic breakthrough is secure clinical targeting access deep areas. After 2 weeks treatment, memory performance improves up 3 months.
Photophobia, the aberrantly increased sensitivity to light, is a common symptom in migraine patients and light discomfort frequently found as trigger for attacks. In behavioral studies, planned exposure was reduce headache with photophobia, potentially by increasing habituation this trigger. Here, we aimed elucidate neurophysiological mechanisms of versus deprivation using functional magnetic resonance imaging (fMRI).Ten (9 female, age = 28.70 ± 8.18 years) 11 healthy controls 23.73 2.24...
Homuncular organization, i.e. the neuronal representation of human body within primary motor cortex, is one most fundamental principles brain. Despite this, in rare peripheral nerve surgery patients, transformation a monofunctional (diaphragm activation) into bifunctional area and arm activation controlled by same cortical area) has previously been demonstrated. The mechanisms behind this are not fully known. To investigate we functional connectivity changes unique highly instructive...