A5069792239- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Migraine and Headache Studies
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Multiple Sclerosis Research Studies
- Ophthalmology and Eye Disorders
- Neurological and metabolic disorders
- Pharmacological Effects and Toxicity Studies
- Peripheral Neuropathies and Disorders
- Cancer Treatment and Pharmacology
- Genetic Neurodegenerative Diseases
- Trigeminal Neuralgia and Treatments
- Synthesis and Biological Evaluation
- Epilepsy research and treatment
- Peripheral Nerve Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Cerebral Venous Sinus Thrombosis
- Advanced Neuroimaging Techniques and Applications
- Botulinum Toxin and Related Neurological Disorders
- Olfactory and Sensory Function Studies
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- Lanthanide and Transition Metal Complexes
Sheikh Shakhbout Medical City
2023-2024
Khalifa University of Science and Technology
2023-2024
University Medical Center Rizk Hospital
2012-2022
Lebanese American University
2010-2021
New York Proton Center
2020
American Headache Society
2020
SMART Reading
2018
Northwestern University
2014
Neurological Surgery
2014
University Hospitals of Cleveland
1988-1992
EMPOwER, a double-blind, randomised, phase 3 study, evaluated the efficacy and safety of erenumab in adults with episodic migraine from Asia, Middle East, Latin America.Randomised patients (N = 900) received monthly subcutaneous injections placebo, 70 mg, or 140 mg (3:3:2) for months. Primary endpoint was change baseline days at Month 3. Other endpoints included achievement ≥50%, ≥75%, 100% reduction days, acute migraine-specific medication treatment patient-reported outcomes, assessment.At...
Migraine, characterized by recurrent headaches and often accompanied other symptoms like nausea, vomiting, sensitivity to light sound, significantly impacts patients' quality of life (QoL) daily functioning. The global burden migraines is reflected not only in terms reduced QoL but also the form increased healthcare costs missed work or school days. While UAE (United Arab Emirates)-specific consensus-based recommendations for effective use preventive calcitonin gene-related peptide...
Neuropathic pain (NeP) has been the focus of extensive basic and clinical research over past 20 years. This led to an increased understanding underlying pathophysiological mechanisms development new therapeutic agents, as well a clearer definition role established medications. To date there are no published treatment guidelines for NeP in Middle East. A multidisciplinary panel East international experts met review critically reach consensus on how best apply evidence-based (mainly peripheral...
Systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes parkinsonism in humans and other primates, but not rats; mice are intermediate their susceptibility which varies among strains. We hypothesized previously that the rat's resistance to systemic MPTP toxicity is likely due unique enrichment of its blood-brain barrier with enzymes metabolize MPTP. metabolites, such as 1-methyl-4-phenylpyridinium (MPP+) 1-methyl-4-phenyl-2,3-dihydropyridinium, may have difficulty traversing...
We studied blood-to-brain entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+) and butanol in anesthetized rats using the indicator-fractionation method with right atrial bolus injection. Minimal amounts MPP+, which has low octanol/water partition coefficient, crossed blood-brain barrier. MPTP butanol, both have high coefficients, were almost completely extracted by all regions brain on first pass. The main difference between tracers is that...
Tremor is an important and common symptom in patients with multiple sclerosis (MS). It constituted one of the three core features MS triad described by Charcot last century. could have a drastic impact on patients' quality life. This paper provides overview tremor future perspectives particular emphasis its epidemiology (prevalence: 25-58%), clinical characteristics (i.e., large amplitude 2.5-7 Hz predominantly postural or intention vs. exaggerated physiological pseudo-rhythmic activity...
Three consecutive daily sessions of cathodal transcranial direct current stimulation (tDCS) was sufficient to show a significant decrease in headache duration and intensity as well tablets consumption, patients suffering from episodic migraine.Migraine prophylaxis is recommended with frequent and/or intense headaches, but poor tolerability lack efficacy preventive drugs are common clinical practice. Hence, new prophylactic strategies needed.The aim this study evaluate the tDCS terms migraine...
Forced displacement and war trauma cause high rates of post-traumatic stress, anxiety disorders depression in refugee populations. We investigated the impact forced on mental health status, gender, presentation type 2 diabetes (T2D) associated inflammatory markers among Syrian refugees Lebanon.Mental status was assessed using Harvard Trauma Questionnaire (HTQ) Hopkins Symptom Checklist-25 (HSCL-25). Additional metabolic were analyzed.Although symptomatic stress scores observed both men...
Abstract Elucidation of the mechanism(s) by which 1‐methyI‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and its active metabolite l‐methyl‐4‐phenylpyridinium (MPP + ) cause parkinsonism in humans other primates has prompted consideration possible endogenous MPTP/MPP ‐like ncurotoxins etiology idiopathic Parkinson's disease. Here we examined inhibition mitochondrial respiration vitro neurotoxicity rats vivo produced β‐carbolinium compounds that are presumed to form following Pictet‐Spengler...
Medication overuse headache (MOH) is a chronic pain syndrome that arises from the frequent use of acute antimigraine drugs. Transcranial direct current stimulation (tDCS) non-invasive brain technique with possible therapeutic effect in this particular context. This was randomized, sham-controlled, cross-over study. Eighteen patients MOH (17 women, age range: 20-38 years) received three sets consecutive daily sessions tDCS: anodal tDCS over prefrontal cortex, cathodal occipital cortex...
Migraine is a common debilitating neurological disorder affecting large proportion of the general population. Calcitonin gene-related peptide (CGRP), 37-amino acid neuropeptide, plays key role in pathophysiology migraine, and development therapies targeting anti-CGRP pathway has revolutionized field migraine treatment. An expert task force neurologists United Arab Emirates (UAE) developed critically assessed recommendations on use CGRP-based treatment management UAE, based available...
Abstract: We synthesized a number of fluorinated analogs 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), and tested their suitability as substrates for monoamine oxidase B in vitro dopaminergic neurotoxicity vivo. Two the compounds tested, 2′‐F‐MPTP 2′‐CF 3 ‐MPTP, were better enzyme possessed more potent nigrostriatal dopamine neurons than MPTP, especially 2′‐F‐MPTP. The results vivo experiments correlated well with oxidase. These findings could serve basis use 18 F‐labeled MPTP...
Investigate the added value of hyperventilation (HV) and intermittent photic stimulation (IPS) to routine electroencephalogram (EEG).This is a retrospective review 1,172 successive EEGs. The records with evidence epileptogenic activity were identified further analyzed identify if activation techniques could trigger expression epileptic not seen otherwise in nonactivated tracing.Activation procedures provided additional information 9.5% abnormal EEG files. They helped establish diagnosis an...
Objective We aimed to examine arterial stiffness and vitamin K2 status in migraine subjects by comparison controls. Background Migraine is a primary headache disorder that has been associated with an increased risk of cardiovascular events. Mechanisms underlying this risk, however, remain unclear. Vitamin deficiency emerged as factor, but never explored subjects. Design Methods This case‐control, single‐center, observational study includes cohort their age‐ sex‐matched Arterial was measured...
Background: Most multiple sclerosis (MS) patients will develop walking limitations during the disease. Sustained-release oral fampridine is only approved drug that improve gait in a subset of MS patients. Objectives: (1) Evaluate cortical excitability effect with disability. (2) Investigate whether changes can predict therapeutic response to fampridine. Method: This prospective observational study enrolled 20 adult and impairment planned receive 10 mg twice daily for two consecutive weeks....