A5055121653- Cancer therapeutics and mechanisms
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Helicobacter pylori-related gastroenterology studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Acute Myeloid Leukemia Research
- Bee Products Chemical Analysis
- Lung Cancer Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiovascular Disease and Adiposity
- Biological Activity of Diterpenoids and Biflavonoids
- Natural product bioactivities and synthesis
- Periodontal Regeneration and Treatments
- Cancer Cells and Metastasis
- HIV/AIDS drug development and treatment
- Synthesis and biological activity
- Hemoglobinopathies and Related Disorders
- Mesenchymal stem cell research
- Digestive system and related health
Northern Jiangsu People's Hospital
2023-2024
Sun Yat-sen University
2024
University of Chinese Academy of Sciences
2024
Shanghai Institute of Materia Medica
2024
Xinjiang Technical Institute of Physics & Chemistry
2024
Jiangnan University
2015
Xinxiang Medical University
2013
Background: Hepatic iron overload is common in patients with myelodysplastic syndromes undergoing hematopoietic cell transplantation (HCT) and may predispose to peri- post-HCT toxicity. To better understand the mechanisms of overload-induced liver injury, we examined effects induced by ferric ammonium citrate (FAC) on oxidative stress apoptosis signaling pathway human hepatic line HH4. Methods Results: HH4 cells were exposed FAC force uptake, cellular responses determined. Incubation 5 mM...
Wound healing in diabetics is often impaired or delayed due to the presence of high reactive oxygen species and low antioxidant levels. Here, a sericin-honey semi-interpenetrating network hydrogel with excellent activity was prepared. Besides, transparent, injectable, sticky, highly porous, has good swelling properties, antibacterial activity, cell compatibility. Based on its performance
Diabetic wounds are serious complications caused by diabetes mellitus (DM), which further exacerbated angiogenesis disorders and prolonged inflammation. Injectable platelet-rich fibrin (i-PRF) is rich in growth factors (GFs) has been used for the repair regeneration of diabetic wounds; however, direct application i-PRF certain disadvantages, including instability bioactive molecules. Sericin hydrogel, fabricated silkworm-derived sericin, a biocompatible material that anti-inflammatory...
This paper mainly studied the effect of ethanol extract Selaginella doederleinii Hieron on proliferation two kinds nasopharyngeal carcinoma cell lines, CNE-1 and C666-1, their mechanisms action. Extract was obtained by heat reflux extraction with ethanol, extracellular matrix adhesion cells, process, as well colony-forming ability were tested using MTT assay. The results showed that yield dry 36.4%. 2.5 g/ml in high concentration group exhibited inhibitory activity directly proportional to...
Abstract Background Intestinal fibrosis is a significant clinical challenge in inflammatory bowel diseases, but no effective anti-fibrotic therapy currently available. GCGR and GLP1R are both peptide hormone receptors involved energy metabolism of epithelial cells. However, their role intestinal the underlying mechanisms remain largely unexplored. Methods tissues from patients with Crohn’s Disease (CD) (n=20) were obtained. AAV9-Glp1r-shRNA, AAV9-Gcgr-shRNA or AAV9-NC-shRNA used to transfect...
<b>Rationale:</b> Fibrotic-niche impairs the capacity of tissue repairing, regeneration and homeostasis maintaining. Dysregulated TGF-β<sub>1</sub> activity as a master orchestrator fibrotic-niche drives vicious cycling fibrosis, synthetic peptide BTI615 is designed to rectify this pathological context. <b>Methods:</b> Rats were intratracheally dosed 0.4 USP bleomycin on Day 1, 200 μg/kg/day aerosol was inhaled from 4-15. SpO<sub>2</sub>, Micro-CT Imaging, histopathology, scRNA-seq,...