A5040621727- Japanese History and Culture
- Retinal Diseases and Treatments
- Retinal Development and Disorders
- Glaucoma and retinal disorders
- Themes in Literature Analysis
- Retinal Imaging and Analysis
- Socioeconomic Development in Asia
- Postcolonial and Cultural Literary Studies
- Geographies of human-animal interactions
- Australian History and Society
- Philippine History and Culture
- Retinal and Optic Conditions
- Psychoanalysis, Philosophy, and Politics
- Photography and Visual Culture
- Artistic and Creative Research
- CRISPR and Genetic Engineering
- Political theory and Gramsci
- Educator Training and Historical Pedagogy
- Doping in Sports
- Martial Arts: Techniques, Psychology, and Education
- Visual Culture and Art Theory
- Globalization and Cultural Identity
- Virus-based gene therapy research
- Literacy, Media, and Education
- Social and Cultural Studies
University of California, Berkeley
2021
Manchester Metropolitan University
2013-2021
Meiji University
2011-2014
Novartis (United States)
2014
Mechanisms to maintain genomic integrity are essential for cells remain viable. Not surprisingly, disruption of key DNA damage response pathway factors, such as ataxia telangiectasia-mutated (ATM)/ataxia telangiectasia and RAD3-related (ATR) results in loss integrity. Here, a synthetic lethal siRNA-screening approach not only confirmed ATM but identified additional replication checkpoint proteins, when ablated, enhanced ATR inhibitor (ATRi) high-content γ-H2AX assay. Cancers with...
Abstract Targeted AAV vectors are needed for safe and efficient delivery to transduction of specific tissue target(s) in patients. Effective intravitreal retina gene therapy is not feasible with wildtype AAV. We employed directed evolution nonhuman primates (NHP) discover an variant (R100) treatment multiple target cells the primate retina. R100 demonstrated superior human retinal compared Furthermore, three R100-based therapeutics safety, delivery, durable pan-retinal expression...
"Normal" versus "Deviant" Play in Children's Literature:An Historical Overview Jenny Holt (bio) It is generally acknowledged that children are need of play and if they deprived play, disastrous consequences may ensue. Thus, a central concern for human rights activists over the past two hundred years has been to ensure, through employment other legislation, entitled leisure time. Indeed, Article 31 U.N. Convention on Rights Child gives "the right . rest leisure, engage recreational activities...
Purpose: To develop a reliable and efficient method for quantifying the area of preserved retinal pigment epithelium (RPE), facilitating evaluation disease progression or response to therapy in choroideremia (CHM). Methods: The fundus autofluorescence images CHM patients were captured at baseline 1 year. A Photoshop-based was developed allow measurement RPE area. results compared with measurements generated by Heidelberg Eye Explorer 2 (HEYEX2). areas measured two independent graders assess...
Click to increase image sizeClick decrease size Notes See the collected papers of Society, dating from 1803 1837, in Carpenter. John Harthover comments that he lives “under good Queen Victoria”, i.e., after 1837. The 1834 Act for Better Regulation Chimney Sweepers and their Apprentices stipulated no child under 10 should be employed as a sweep (An 257), so any Victorian householder hiring boy would have been breach law, even before 1840 act. Terasaki full history this episode.
Abstract The article as a whole seeks to explore new ways of looking at the literature intercultural encounter using ideas culture shock, cultural adaptation and narrative theory. It also demonstrates importance Anglophone about Japan understanding how writers from late nineteenth early twentieth centuries sought engage with people other ethnic groups. From 1850s, when ended its policy national isolation, until beginning World War II, literary marketplace was flooded numerous...
A Lesson to "the Western Barbarian":Culture and Civility in British American Debates on Japanese Decorative Art during the Meiji Period Jenny Holt (bio) Everything is artistic, every step provides a new picture, child street has an artist's eye. The little girls arrange their bouquets as though they were students of Ruskin, each all Japan make harmony colour perfect study. —Kate Lawson, Highways Homes (1910; 98–99) handful studies that have considered Victorian reception art generally used...
Purpose: Intravitreal delivery of therapeutic transgenes to the retina via engineered viral vectors can provide sustained local concentrations proteins and thus potentially reduce treatment burden improve long-term vision outcomes for patients with neovascular (wet) age-related macular degeneration (AMD), diabetic edema (DME), retinopathy. Methods: We performed directed evolution in nonhuman primates (NHP) invent an adeno-associated (AAV) variant (R100) capacity cross vitreoretinal barriers...
This article evaluates a transition intervention project aimed at first-year undergraduate filmmaking students in the Manchester School of Art. In response to recently identified shifts confidence and resilience linked an increased rate withdrawal, Scholarship Teaching Learning research was undertaken address issue develop strategy promote engagement, progression. Research into studies retention, analysis both pedagogical context course wider ecology discipline, informed remodelling autumn...
Abstract The article as a whole seeks to explore new ways of looking at the literature intercultural encounter using ideas culture shock, cultural adaptation, and narrative theory. It also demonstrates importance Anglophone about Japan understanding how writers from late 19th early 20th centuries sought engage with people other ethnic groups. From 1850s, when ended its policy national isolation, until beginning World War II, literary marketplace was flooded numerous English‐language texts,...
Japan as an Exemplum of Social Order in Turn-of-the-Century British and American Educational Literature: Filial Paradise Jenny Holt It is a common presumption among scholars Orientalism that the business producing discourses about East must be one-way process; powerful West creates fantasy east to justify its colonialist endeavors, subjugate non-European peoples for profit resources flatter Western ego. However, if we add another dimension equation—that class—the picture changes. Often...
The travel books of Isabella Bird are noted for their accuracy and close attention to detail, measurements statistics. In general, Unbeaten Tracks in Japan (1880) is no exception. However, when describing physical size, vastly exaggerates the smallness Japanese while depicting herself as much larger comparison – despite being roughly same size average subject herself. this article, I argue that Bird’s distortions can be read a sign neurosis, demonstrate how subsequent writers such Pierre...
Perhaps, in Hopkins' case, "the question" should really be "who is to master?" I will here argue that, rather than merely dealing, as Humpty does, with bad-tempered adjectives and sulking verbs, Hopkins engages a far wider contest for mastery of both language textuality. In this, he embarks on modified version Hegel's Master-Slave dialectic, constantly testing power boundaries human divine beings. The clinch this struggle the prerogative inscribe himself an authoritative figure within...