A5043166597- Herpesvirus Infections and Treatments
- interferon and immune responses
- Innovative Teaching Methods
- Problem and Project Based Learning
- Healthcare and Venom Research
- Teacher Education and Leadership Studies
- Allergic Rhinitis and Sensitization
- Down syndrome and intellectual disability research
- Viral Infections and Vectors
- Asthma and respiratory diseases
- Biomedical and Engineering Education
- Online and Blended Learning
- Bartonella species infections research
- Innovations in Medical Education
- Dermatology and Skin Diseases
- Viral Infections and Outbreaks Research
- Collaborative Teaching and Inclusion
- Food Allergy and Anaphylaxis Research
- HER2/EGFR in Cancer Research
- Sleep and related disorders
- Digital and Traditional Archives Management
- Experimental Learning in Engineering
- SARS-CoV-2 detection and testing
- RNA regulation and disease
- Atherosclerosis and Cardiovascular Diseases
Regis University
2017-2022
Adelphi Group (United Kingdom)
2019-2020
University of Colorado Denver
2012-2015
Louisiana State University Health Sciences Center Shreveport
2014
Louisiana State University
2014
University of Colorado Anschutz Medical Campus
2013
University of Northern Colorado
2012
Seagen (United States)
2005
Effective antibody-drug conjugates (ADC) combine high drug-linker stability in circulation and efficient intratumoral release of drug. Conjugation monomethyl auristatin E (MMAE) to the anti-CD30 monoclonal antibody (mAb), cAC10, produced a selective potent ADC against CD30(+) anaplastic large cell lymphoma Hodgkin's disease models. This ADC, cAC10-valine-citrulline-MMAE, uses protease-sensitive dipeptide linker designed MMAE by lysosomal cathepsin B target cells but maintain stable linkage...
ABSTRACT Tacaribe virus (TCRV) was first isolated from 11 Artibeus species bats captured in Trinidad the 1950s during a rabies surveillance program. Despite significant effort, no evidence of infection other mammals, mostly rodents, found, suggesting that vertebrates harbored TCRV. For this reason, it hypothesized TCRV naturally hosted by artibeus bats. This is stark contrast to arenaviruses with known hosts, all which are rodents. To examine hypothesis, we conducted experimental infections...
Allergic respiratory diseases such as allergic rhinitis (AR) and asthma (AA) are common conditions that can influence sleep daytime functioning. However, the significance of this impact is unclear-particularly in perennial allergy sufferers. This study investigates on sleep, daily activities productivity.Adults with self-reported or physician-diagnosed AR aged ≥ 18 years were recruited Denmark, France, Germany Sweden. Allergy sufferers identified using online panels closely matching national...
Like varicella-zoster virus (VZV), simian varicella (SVV) reactivates to produce zoster. In the present study, 5 rhesus macaques were inoculated intrabronchially with SVV, and months later, 4 monkeys immunosuppressed; 1 monkey was not immunosuppressed but subjected stress of transportation. monkeys, a zoster rash developed 7 12 weeks after immunosuppression, also in that immunosuppressed. Analysis at 24 48 h revealed SVV antigen lung alveolar wall, ganglionic neurons nonneuronal cells, skin...
The suprachiasmatic nucleus (SCN) plays a critical role in maintaining melatonin and sleep-wake cycles.We report case of 38-year-old woman who, after gunshot wound to the right temple, developed sleep complaint multiple nocturnal awakenings several naps throughout day.Computerized tomography magnetic resonance imaging revealed bilateral optic nerve chiasm damage. Diagnostic polysomnography actigraphy an irregular wake rhythm.We speculate concurrent damage SCN nerves bilaterally resulted...
In varicella-zoster virus (VZV)-infected primary human brain vascular adventitial fibroblasts (BRAFs), levels of beta interferon (IFN-β,) STAT1, and STAT2 transcripts as well STAT1 protein were decreased. IFN-α transcript increased but not secreted levels. Compared to IFN-α-treated control results, in VZV-infected BRAFs, phosphorylated did translocate the nucleus, resulting impaired downstream expression interferon-inducible antiviral Mx1. Overall, VZV interference with type I pathway may...
Objective. To determine the indicators of quality for application activities in pharmacy team-based learning (TBL).Methods. A modified Delphi process was conducted with TBL experts. Twenty-three experts met inclusion criteria, including having at least four years experience, designing eight sessions, training others to use TBL, and authoring a peer-reviewed paper. In round 1, panelists responded five open-ended questions about their successful applications activities, satisfaction activity...
Objective: To describe an elective course on immunology and vaccines for pharmacy students that extends beyond basic immunization training.
 Design: A three credit-hour Immunology Vaccines was developed taught by immunologist, policy research expert, pharmacist. The learning objectives of the included: understanding how immune system works with to provide protection against infectious diseases, history policies involved in practice, counsel vaccine hesitant individual. Classes were...
Abstract Down syndrome (Trisomy 21; T21) results from an extra copy of chromosome 21. This in a myriad abnormalities, including immune dysfunction. Previous research has focused only on children with T21. However, improved medical interventions and treatments have led to rapid increase the lifespan people Thus, there is now population adults T21 critical gap our understanding immunity these adults. It well known that are far more likely die respiratory infections compared their disomic...
Abstract Varicella zoster virus (VZV) is the only human known to replicate in cerebral arteries and produce stroke. After reactivation, travels transaxonally from ganglia initially infects arterial adventitia. To analyze virus-host relationship, we infected primary cerebrovascular adventitial fibroblasts with VZV studied interferon-α initiated STAT pathway, which commonly activated after infection. Quantitative PCR showed that expression of STAT1, STAT2 Mx1 mRNA were significantly decreased...
Abstract Primary varicella zoster virus (VZV) infection causes (chickenpox), after which becomes latent in ganglionic neurons. A declining cell-mediated immunity to VZV leads reactivation, manifesting as (shingles). Zoster is often complicated by chronic pain (post herpetic neuralgia) and other serious neurological disorders such meningoencephalitis myelitis. vasculopathy results transient ischemic attacks stroke, the result of productive cerebral arteries. More than 90% 6.75 billion world...
Click to increase image sizeClick decrease size Notes 1. The volume contents shows the full list of articles in Volume 25.