A5102845580- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Mental Health Research Topics
- Enzyme Structure and Function
- Protein Structure and Dynamics
- Child and Adolescent Psychosocial and Emotional Development
- Functional Brain Connectivity Studies
- Cell Adhesion Molecules Research
- Cultural Differences and Values
- Advanced NMR Techniques and Applications
- Neural and Behavioral Psychology Studies
- Digital Mental Health Interventions
- Mental Health Treatment and Access
- GABA and Rice Research
- Early Childhood Education and Development
- Sports and Physical Education Research
- Interpreting and Communication in Healthcare
- Stress Responses and Cortisol
- Psychotherapy Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Traumatic Brain Injury Research
- Microbial Inactivation Methods
- Social and Intergroup Psychology
- Attachment and Relationship Dynamics
Dartmouth College
2020-2024
New York State College of Agriculture & Life Sciences
2024
Cornell University
2024
Dartmouth Hospital
2024
University of California, Los Angeles
2015-2022
University of Chicago
2006-2022
University of Washington
2016
Seagen (Canada)
2012
University of Washington Bothell
2012
Clay Technology (Sweden)
2005
An antibody-drug conjugate consisting of monomethyl auristatin E (MMAE) conjugated to the anti-CD30 monoclonal antibody (mAb) cAC10, with eight drug moieties per mAb, was previously shown have potent cytotoxic activity against CD30(+) malignant cells. To determine effect loading on therapeutic potential, we assessed cAC10 conjugates containing different drug-mAb ratios in vitro and vivo.Coupling MMAE cysteines that comprise interchain disulfides created an population, which purified using...
Site-specific conjugation of small molecules and enzymes to monoclonal antibodies has broad utility in the formation conjugates for therapeutic, diagnostic, or structural applications. Precise control over location would yield highly homogeneous materials that could have improved biological properties. We describe first time chemical reduction oxidation methods lead preferential cleavage particular antibody interchain disulfides using anti-CD30 IgG1 cAC10. Alkylation resulting cAC10 cysteine...
Little is known about how racism and bias may be communicated in the medical record. This study used machine learning to analyze electronic health records (EHRs) from an urban academic center investigate whether providers' use of negative patient descriptors varied by race or ethnicity. We analyzed a sample 40,113 history physical notes (January 2019-October 2020) 18,459 patients for sentences containing descriptor (for example, resistant noncompliant) patient's behavior. mixed effects...
Effective antibody-drug conjugates (ADC) combine high drug-linker stability in circulation and efficient intratumoral release of drug. Conjugation monomethyl auristatin E (MMAE) to the anti-CD30 monoclonal antibody (mAb), cAC10, produced a selective potent ADC against CD30(+) anaplastic large cell lymphoma Hodgkin's disease models. This ADC, cAC10-valine-citrulline-MMAE, uses protease-sensitive dipeptide linker designed MMAE by lysosomal cathepsin B target cells but maintain stable linkage...
The authors developed a novel technique for the reconstruction of large segmental long bone defects using cylindrical titanium mesh cage (CTMC). Although initial clinical reports have been favorable, CTMC has yet to be validated in clinically relevant animal model, which is purpose this study. Under general anesthesia, unilateral, 3-cm mid-diaphyseal defect was created femur an adult canine. consisted that packed and surrounded with standard volume morselized canine cancellous allograft...
Importance Chronic back pain (CBP) is a leading cause of disability. Placebo treatments often provide as much relief bona fide treatments, such steroid injections. Open-label (honestly prescribed) placebos (OLPs) may relieve CBP without deception, but OLP mechanisms remain poorly understood. Objective To investigate the long-term efficacy and neurobiological for CBP. Design, Setting, Participants A randomized clinical trial with longitudinal functional magnetic resonance imaging (MRI)...
Background:Even with recent advances in psychological treatments and mobile technology, online computerized therapy is not yet popular. College students, ubiquitous access to experiencing high distress, often nontreatment seekers, could be an important area for treatment dissemination. Finding ways reach out college students by offering interventions through devices, applications they use, might increase their engagement treatment.Introduction:This study evaluates students' reported...
Neuroticism has been associated with depression and anxiety both cross-sectionally longitudinally. Interpretive bias anxiety, primarily in cross-sectional induction studies. The purpose of the current study was to examine role interpretive as a prospective risk factor mediator relation between neuroticism depressive anxious symptoms young adults assessed significantly predicted broad general-distress dimension but not intermediate fears anhedonia-apprehension dimensions or narrow...
Anxiety disorders are chronic, pervasive, and debilitating; characterised by a persistent or exaggerated response to distal abstract threats. Impaired threat discrimination (distinguishing safe from threatening stimuli) impaired extinction (learning once stimulus is now safe), known risk factors in the development persistence of anxiety disorders. These effects can be experimentally elicited through fear conditioning. First, repeated trials paired aversive neutral stimuli delivered during...
Fear conditioning models key processes related to the development, maintenance and treatment of anxiety disorders is associated with group differences in anxiety. However, laboratory administration tasks time cost intensive, precluding assessment large samplesnecessary for analysis individual differences. This study introduces a newly developed smartphone app that delivers fear paradigm remotely using loud human scream as an aversive stimulus. Three groups participants (total n = 152) took...
Anhedonia is a risk factor for suicide and poor treatment response in depressed individuals. Most evidence-based psychological therapies target symptoms of heightened negative affect (e.g., inferential style) instead deficits positive attenuated reward response) typically show little benefit anhedonia. Viewing scenes through virtual reality (VR) has been shown to increase holds great promise addressing anhedonic symptoms. In this pilot study, six participants with clinically significant...
The 4th World Antibody Drug Conjugate (WADC) Summit, organized by Hanson Wade was held on February 29‑March 1, 2012 in Frankfurt, Germany, which also the location for Summit Europe 2011. During one year between these meetings, antibody drug conjugates (ADCs) have confirmed their technological maturity and clinical efficacy oncology. Brentuximab vedotin (ADCETRISTM) gained approval US Food Administration August 2011 trastuzumab emtansine (T-DM1) impressive responses a large cohort of breast...
Previous research has shown that the habit of suppressing emotional expressions is associated with long-term, general reductions in social cognitive abilities and interpersonal adjustment. This may be because theoretically, habitual suppression requires fixation attention to self instead others. The present explored association between tendency suppress one’s own emotions accuracy recognizing Emotion recognition was tested across two tasks, a limited-channel task presents limited information...
Cognitive neuroscience has advanced significantly due to the availability of openly shared datasets. Large sample sizes, large amounts data per person, and diversity in tasks types are all desirable, but difficult achieve a single dataset. Here, we present an open dataset with N = 101 participants 6 hours scanning participant, multifaceted cognitive including 2 naturalistic movie viewing. This datasets' combination ample size, extensive more than 600 worth data, wide range experimental...
Abstract In this paper, elevated pressures up to 750 atm (1 = 101 kPa) were found have a strong stabilizing effect on two extremely thermophilic glutamate dehydrogenases (GDHs): the native enzyme from hyperthermophile Pyrococcus furiosus ( Pf ), and recombinant GDH mutant containing an extra tetrapeptide at C‐terminus (rGDH t ). The presence of greatly destabilized ambient pressure; however, destabilizing was largely reversed by application pressure. Electron spin resonance (ESR)...
Abstract Posttraumatic stress disorder (PTSD) is often complicated by the after-effects of mild traumatic brain injury (mTBI). The mixture conditions results in abnormal affective and cognitive functioning, as well maladaptive behavior. To better understand how activity explains emotional processes these conditions, we used an N-back task functional magnetic resonance imaging (fMRI) to study neural responses US military veterans after deployments Iraq Afghanistan. Additionally, sought...
Abstract In this study, we investigated the effect of pressure on protein structure and stability at high temperature. Thermoinactivation experiments 5 500 atm were performed using wild‐type (WT) enzyme two single mutants (D167T T138E) glutamate dehydrogenase (GDH) from hyperthermophile Thermococcus litoralis . All three GDHs stabilized, although to different degrees, by application atm. Interestingly, degree stabilization correlated with GDH as well magnitude electrostatic repulsion created...