A5101798328- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Functional Brain Connectivity Studies
- Genomics and Chromatin Dynamics
- RNA and protein synthesis mechanisms
- Sexual function and dysfunction studies
- EEG and Brain-Computer Interfaces
- Neural and Behavioral Psychology Studies
- Hormonal and reproductive studies
- Advanced NMR Techniques and Applications
- Bipolar Disorder and Treatment
- Neurological disorders and treatments
- Ubiquitin and proteasome pathways
University of British Columbia
1969-2022
BC Mental Health & Substance Use Services
2019-2022
McGill University
2022
Abstract Numerous cancers, including prostate cancer (PCa), are addicted to transcription programs driven by specific genomic regions known as super-enhancers (SEs). The robust of genes at such SEs is enabled the formation phase-separated condensates factors and coactivators with intrinsically disordered regions. androgen receptor (AR), main oncogenic driver in PCa, contains large co-recruited transcriptional coactivator mediator complex subunit 1 (MED1) androgen-dependent PCa cells, thereby...
Abstract Numerous cancers, including prostate cancer (PCa), are addicted to transcription programs driven by superenhancers (SEs). The of genes at SEs is enabled the formation phase-separated condensates factors and co-activators with intrinsically disordered regions. androgen receptor (AR), main oncogenic driver in PCa, contains large regions co-recruited co-activator MED1 promote programs. In this work, we show that dynamic AR-rich, liquid-like foci form PCa models upon stimulation...
Testosterone is associated with sexual desire and performance in men, but little known about cognitive mechanisms underlying this relationship. Even less the influence of estradiol, despite its production from testosterone, high receptor density brain regions related to male behavior. We used eye-tracking compare men's visual attention images fully clothed (i.e. neutral) minimally sexy) models three groups: androgen-deprived (n = 6) not prostate cancer 11), healthy controls 7). also assessed...
Abstract Numerous cancers, including prostate cancer (PCa), have been shown to be addicted transcription programs driven by specific genomic sites known as superenhancers (SEs). Recently, it has proposed that the robust of genes at such SEs is enabled formation phase-separated condensates factors and coactivators with intrinsically disordered regions. The androgen receptor (AR), main oncogenic driver in PCa, contains large regions co-recruited transcriptional coactivator MED1...