A5012443442- Autophagy in Disease and Therapy
- Toxoplasma gondii Research Studies
- Malaria Research and Control
- Ubiquitin and proteasome pathways
- Mosquito-borne diseases and control
- Complement system in diseases
- Drug Transport and Resistance Mechanisms
- Trypanosoma species research and implications
National Institute of Immunology
2017-2022
ABSTRACT Mechanisms by which 3′-phosphorylated phosphoinositides (3′-PIPs) regulate the development of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are poorly understood. The catabolic process autophagy, is dependent on autophagy-related proteins (ATGs), one major targets 3′-PIPs in yeast mammals. In present study, we identified protein ATG18 as an effector these parasites. P . (PfATG18) T (TgATG18) interact with but exhibited differences their specificity interaction...
Cerebral malaria (CM), a life-threatening complication of Plasmodium falciparum infection, is characterized by the sequestration infected erythrocytes in brain microvasculature. Our study investigated potential repurposing anti-cancer BCR-ABL drugs, also known to be effective against P. blood-stage parasites, for mitigating inflammation and blood-brain barrier breakdown CM. analysis demonstrated differential protective effects drugs on primary human microvascular endothelial cells (HBMEC)...
Apicomplexan parasites are causative agents of major human diseases. Calcium Dependent Protein Kinases (CDPKs) crucial components for the intracellular development apicomplexan and thus considered attractive drug targets. CDPK7 is an atypical member this family, which initial characterization suggested to be critical both Apicomplexa Plasmodium falciparum Toxoplasma gondii . However, mechanisms via it regulates parasite replication have remained unknown. We performed quantitative...
Phosphoinositides are important second messengers that regulate key cellular processes in eukaryotes. While it is known a single phosphoinositol-3 kinase (PI3K) catalyses the formation of 3’-phosphorylated phosphoinositides (PIPs) apicomplexan parasites like Plasmodium and Toxoplasma , how its activity PI3P regulated has remained unknown. Present studies involving unique Vps15 protein (TgVPS15) gondii provides insight into regulation phosphatidyl-3-phosphate (PI3P) generation unravels novel...
Abstract Phosphoinositides are important second messengers that regulate key cellular processes in eukaryotes. While it is know a single phosphoinositol-3 kinase (PI3K) catalyses the formation of 3’-phosphorylated phosphoinositides (PIPs) apicomplexan parasites Plasmodium and Toxoplasma, how its activity PI3P regulated has remained unknown. Present studies involving unique Vps15 like protein (TgVPS15) Toxoplasma gondii provide insights into regulation phosphatidyl-3-phosphate (PI3P)...