A5086806586- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Neurological Complications and Syndromes
- Moyamoya disease diagnosis and treatment
- Genetics and Neurodevelopmental Disorders
- Psychosomatic Disorders and Their Treatments
- Fetal and Pediatric Neurological Disorders
- Neonatal and fetal brain pathology
- Autoimmune Neurological Disorders and Treatments
- Neurological disorders and treatments
- Schizophrenia research and treatment
- Cerebrospinal fluid and hydrocephalus
- Diet and metabolism studies
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Neurological and metabolic disorders
- Cerebrovascular and Carotid Artery Diseases
- Infectious Encephalopathies and Encephalitis
- Glycogen Storage Diseases and Myoclonus
- Venous Thromboembolism Diagnosis and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Genomics and Rare Diseases
- RNA regulation and disease
- Connexins and lens biology
Hospital São Lucas da PUCRS
2016-2025
Pontifícia Universidade Católica do Rio Grande do Sul
2014-2025
Universidade Luterana do Brasil
2025
Cleveland Clinic
2018
Instituto do Cérebro
2014-2017
Hospital Ernesto Dornelles
2011
To evaluate a novel approach to control epileptic drop attacks through selective posterior callosotomy, sparing all prefrontal interconnectivity.Thirty-six patients with refractory had callosotomy and prospective follow-up for >4 years. Falls, episodes of aggressive behavior, IQ were quantified. Autonomy in activities daily living, axial tonus, speech generated functional score ranging from 0 13. Subjective effect on patient well-being caregiver burden was also assessed.Median monthly...
Focal cortical dysplasia (FCD) is a malformation of development characterized by heterogeneous group lesions with high epileptogenic activity. Somatic mutations in the mTOR pathway are primary cause malformations (MCDs). Activation WNT inhibits GSK3, which key inhibitor mTOR; consequently, activation associated increased pathway. Residual samples were obtained from neocortex five patients diagnosed FCD type IIb who underwent surgery. For control group, residual 3 temporal lobe epilepsy...
Summary Objective We aimed to determine the rates and predictors of resection seizure freedom after bilateral stereo‐electroencephalography ( SEEG ) implantation. Methods reviewed 184 patients who underwent implantation (2009‐2015). Noninvasive invasive evaluation findings were collected. Outcomes interest included subsequent freedom. Statistical analyses employed multivariable logistic regression proportional hazard modeling. Preoperative postoperative frequency, severity, quality life...
Posterior reversible encephalopathy syndrome (PRES) is a clinical-radiologic entity not yet understood, that presents with transient neurologic symptoms and particular radiological findings. Few papers show the differences between pregnant non-pregnant patients. We review cases of 38 women diagnosed PRES, in order to find significant (18) (20) found among age patients (25.83 years old 29.31 non pregnant; P=0.001); mean highest systolic blood pressure, was higher group (185:162 mmHg;...
Rasmussen’s encephalitis (RE) stands as a rare neurological disorder marked by progressive cerebral hemiatrophy and epilepsy resistant to medical treatment. Despite extensive study, the primary cause of RE remains elusive, while its histopathological features encompass cortical inflammation, neuronal degeneration, gliosis. The underlying molecular mechanisms driving disease progression remain largely unexplored. In this case we present patient with who underwent hemispherotomy has remained...
We describe a patient with unilateral periventricular nodular heterotopia (PNH) and drug-resistant epilepsy, whose SEEG revealed that seizures were arising from the PNH, almost simultaneous involvement of heterotopic neurons ("micronodules") scattered within white matter, subsequently overlying cortex. Laser ablation nodules adjacent matter rendered seizure free. This case elucidates "micronodules" in between cortex might be another contributor complex epileptogenicity heterotopia. Detecting...
BACKGROUND:Miyoshi myopathy (MM) is an autosomal-recessive muscle disorder caused by mutations in the DYSF gene. Clinical features and histopathological changes dysferlinopathies may mimic inflammatory myopathies a high degree of clinical suspicion required to guide genetic investigation. CASE REPORT:We report case 16-year-old male who presented with severe bilateral calf pain elevated CK levels (15 000 IU/l) was on prolonged steroid therapy prompted myopathy. Three years into his illness,...
Subdural hematoma (SH) is a neurosurgical emergency, usually caused by head trauma. Non-traumatic causes include aneurysm or arterial–venous malformation rupture, coagulopathy and others. We report the case of 66 year-old man who developed apparently unprovoked signs increased intracranial pressure. Brain computed tomography scan showed an acute spontaneous SH, surgically treated. Throughout surgery, ruptured cortical artery with intensive bleeding appeared was cauterized. After patient...
Background. Stroke is a leading cause of mortality and disability in Brazil around the world. Cardioembolism responsible for nearly 30% origins ischemic stroke. Methods. We analyzed data 256 patients with cardioembolic stroke (according to TOAST classification) who were admitted into Hospital São Lucas-PUCRS from October 2011 January 2014. The subtype was divided six subgroups: arrhythmias, valvular heart disease, coronary artery cardiomyopathy, septal abnormalities, intracardiac injuries....
Ocular myositis (OM) is a rare clinical entity characterized by idiopathic, nonspecific inflammation of primarily or exclusively extraocular muscles (EOM). Presentation usually encompasses painful diplopia, exacerbated eye movement. We report two cases idiopathic OM with unique characteristics. The first presented pseudo-sixth nerve palsy due to medial nucleus and the second recurrent OM, subsequently affecting both eyes. Knowledge different patterns presentation recurrence are important...