A5056138209- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- Protein Degradation and Inhibitors
- Reproductive System and Pregnancy
- CAR-T cell therapy research
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Reproductive tract infections research
- Colorectal and Anal Carcinomas
- T-cell and Retrovirus Studies
- Cardiac Imaging and Diagnostics
- Viral-associated cancers and disorders
- Epigenetics and DNA Methylation
- Inflammasome and immune disorders
- Endometriosis Research and Treatment
- Coronary Interventions and Diagnostics
- Ginseng Biological Effects and Applications
- Preterm Birth and Chorioamnionitis
- Head and Neck Cancer Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Diagnosis and Treatment
University of Cincinnati
2018-2023
Cincinnati Children's Hospital Medical Center
2023
University of Cincinnati Medical Center
2020
University of Tennessee Health Science Center
2015-2020
West Cancer Center
2015-2017
University of Tennessee at Knoxville
2017
Middle Tennessee State University
2013-2016
Dysregulation of innate immune signaling is a hallmark hematologic malignancies. Recent therapeutic efforts to subvert aberrant in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) have focused on the kinase IRAK4. IRAK4 inhibitors achieved promising, though moderate, responses preclinical studies clinical trials for MDS AML. The reasons underlying limited remain unknown. In this study, we reveal that inhibiting leukemic cells elicits functional complementation compensation by...
// Ying Gao 1 , Renbin Huang 2 Yixuan Gong 3 Hyo Sim Park Qingwei Wen Nadin Marwan Almosnid Uma D. Chippada-Venkata Najlaa Abdulrhman Hosain Eric Vick Anthony Farone and Elliot Altman Tennessee Center for Botanical Medicine Research the Department of Biology, Middle State University, Murfreesboro, Tennessee, USA Pharmaceutical College, Guangxi Medical Nanning, Guangxi, PR China Division Hematology Oncology, The Tisch Cancer Institute, Mount Sinai School Medicine, New York, Correspondence to:...
// Shariful Islam 1, * , Eric Vick 2, Bryan Huber 2 Carla Morales Catherine Spier 3 Laurence Cooke 4 Weterings 5 and Daruka Mahadevan 1 Cancer Biology GIDP, University of Arizona Center, Tucson, AZ 85724, USA West Center Tennessee Health Sciences Memphis, TN 38163, Department Hematopathology, Arizona, Medicine, The Radiation Oncology, These authors have contributed equally to this work Correspondence to: Mahadevan, email: dmahadevan@uacc.arizona.edu Keywords: T-cell lymphoma; immune...
Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and emerging evidence suggests that MDS hematopoietic stem progenitor cells (HSPC) exhibit an altered response to inflammation. Deletion chromosome 5 (del(5q)) most common chromosomal abnormality in MDS. Although this subtype contains several haploinsufficient genes impact innate immune signaling, effects inflammation on del(5q) HSPC remains undefined. Utilizing a model del(5q)-like MDS, inhibiting...
In head and neck squamous cell carcinoma (HNSCC), anti-PD-1 inhibitors are approved for recurrent/metastatic (R/M) disease anticipated to expand other indications. The impact of p16 status anatomical site on overall survival (OS) in immunotherapy-treated HNSCC patients remains unresolved. We performed a retrospective analysis R/M receiving immunotherapy at our academic medical center with an extensive community satellite network. Fifty-three were treated had median OS 6 months. Anatomical...
Radiation exposure for the average coronary stent placement varies based on a number of factors but typically amounts to 6-11 mSv per patient (compared 3 background). As with all procedures which utilize radiation, there is an inherent risk genetic mutation and possible development malignancy. Here, we present case 75-year-old male who presented exophytic mass his back following prolonged catheterization radiation burn seven years prior. Biopsy lesion revealed was consistent undifferentiated...
In diffuse large B-cell lymphoma (DLBCL), chromosomal aberrations are known to increase with advancing age. Our study aims determine if there other genetic associated DLBCL based on age.Using the Mitelman Database of Genetic Aberrations, we were able find 749 cases genomic a median age 62 years. Patients aberration analysis results divided into four groups (0 - 30, 31 50, 51 70, > 71 years) and examined by chi-square Mantel-Cox for survival analysis.Ten found be significant particular range:...
From the ∗Departments of Internal Medicine †Pathology ‡Pulmonology and Critical Care Medicine, University Cincinnati Medical Center, Cincinnati, OH. The authors have no financial disclosures. It should be noted that this represents an off-label use epoprostenol. Currently, it is only Food Drug Administration approved in United States for treatment pulmonary artery hypertension, not as a Raynaud phenomenon. conflicts interest related to topic. Correspondence: Eric Vick, MD, PhD, Department...
<h3>Background</h3> The use of immune checkpoint inhibitors (ICI) has increased significantly in the past five years, along with number available drugs and regimens. ICIs have dramatically survival cancer patients, however, there been data to show that they reduced efficacy presence antibiotics.<sup>1</sup> Antibiotic prior during ICI therapy was associated worsening clinical outcomes patients renal cell carcinoma,<sup>2</sup> melanoma,<sup>3</sup> non-small-cell-lung-cancer.<sup>4</sup>...
Abstract Intrauterine inflammation during pregnancy can cause prenatal brain injury, and is associated with preterm birth. Gardnerella vaginalis (GV) a gram variable rod bacterial vaginosis, pelvic inflammatory disease, bacteremia, Bacterial vaginosis samples demonstrate up-regulation of Toll-like Receptor 2 4 mRNA secretion IL-1β in cultured trophoblasts. It has not been clearly demonstrated that isolated GV specimens are capable the characteristic downstream effectors monocytes. We set out...
ABSTRACT Gardnerella vaginalis is a Gram-variable bacterium associated with bacterial vaginosis, common vaginal inflammation in women of reproductive age. This study reports the whole-genome sequencing for clinical isolate strain ATCC 49145. The draft genome composed 21 contigs containing 1,325 protein-coding sequences, 45 tRNAs and single tmRNA (SsrA).
e23141 Background: Discovered as a novel aberration in congenital fibrosarcoma (CF), the ETV6-NTRK3 translocation (EN) confers oncogenic potential and is inhibited by crizotinib. The present study aims to survey scope of neoplasms that harbor EN across tumor types. Methods: Utilizing National Cancer Institute’s Mitelman Database (MD) Chromosome Aberrations Gene Fusions patients (pts) were identified with categorized based on type, subtype incidence. pts who received profiling Caris also...
7551 Background: The prognosis, response to therapy and curability of FL3 is controversial. 5-year Overall Survival (OS) in the literature ranges from 35-72% (Ganti 2006). aim this study was compare OS for patients with early-stage managed single- multi-agent chemotherapy (CT) without radiotherapy (RT). Methods: We identified (pts) diagnosed stage I & II between 2004 – 2012 NCDB categorized into 3 groups based on pts given single agent CT or RT were combined due small sample sizes...
e19022 Background: There has been some improvement in overall survival (OS) for patients with MCL over the past years [Gordon 2014]. However, side effects of treatment remain a major concern. With introduction novel therapies like IT, it is imperative to optimize regimens improve while minimizing toxicity. Methods: (pts) who were diagnosed 2013 or later information available about chemotherapy (CT) and IT did not receive transplant extracted from NCDB. Pts assigned age categories sorted into...