A5075352229- Machine Learning in Bioinformatics
- Malaria Research and Control
- Retinal Development and Disorders
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- vaccines and immunoinformatics approaches
- Multisensory perception and integration
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Glycosylation and Glycoproteins Research
- Noise Effects and Management
- Lipid Membrane Structure and Behavior
- Hearing Loss and Rehabilitation
University of Maryland, College Park
2021-2024
Sustained drug delivery strategies have many potential benefits for treating a range of diseases, particularly chronic diseases that require treatment years. For ocular patient adherence to eye drop dosing regimens and the need frequent intraocular injections are significant barriers effective disease management. Here, we utilize peptide engineering impart melanin binding properties peptide-drug conjugates act as sustained-release depot in eye. We develop super learning-based methodology...
Abstract Malaria vaccine development is hampered by extensive antigenic variation and complex life stages of Plasmodium species. Vaccine has focused on a small number antigens, many which were identified without utilizing systematic genome-level approaches. In this study, we implement machine learning-based reverse vaccinology approach to predict potential new malaria candidate antigens. We assemble analyze P. falciparum proteomic, structural, functional, immunological, genomic,...
Glaucoma is the leading cause of irreversible blindness worldwide. Elevated intraocular pressure (IOP) one major risk factors for glaucoma onset and progression, available pharmaceutical interventions are exclusively targeted at IOP lowering. However, degeneration retinal ganglion cells (RGCs) may continue to progress despite extensive lowering IOP. A complementary strategy reduction use neuroprotective agents that interrupt process cell death by mechanisms independent Here, we describe an...
Intensive malaria control and elimination efforts have led to substantial reductions in incidence over the past two decades. However, reduction Plasmodium falciparum cases has a species shift some geographic areas, with P. vivax predominating many areas outside of Africa. Despite its wide distribution, vaccine development lagged far behind that for falciparum, part due inability cultivate vitro, hindering traditional approaches antigen identification. In prior study, we used...
Aging and hearing loss cause communication difficulties, particularly for speech perception in demanding situations, which have been associated with factors including cognitive processing extended high-frequency (>8 kHz) hearing. Quantifying such associations finding other (possibly unintuitive) is well suited to machine learning. We constructed ensemble models 443 participants who varied age loss. Audiometric, perceptual, electrophysiological, data were used predict noise, reverberation,...