A5049944541- Bariatric Surgery and Outcomes
- Bladder and Urothelial Cancer Treatments
- Esophageal and GI Pathology
- Prostate Cancer Treatment and Research
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Breast Lesions and Carcinomas
- Head and Neck Cancer Studies
- Cancer and Skin Lesions
- HER2/EGFR in Cancer Research
- Urinary and Genital Oncology Studies
- Acute Myocardial Infarction Research
- Colorectal Cancer Screening and Detection
- Diet and metabolism studies
- Peptidase Inhibition and Analysis
- Renal cell carcinoma treatment
- Body Contouring and Surgery
- Vascular Procedures and Complications
- Cancer-related Molecular Pathways
- Colorectal Cancer Treatments and Studies
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Obesity and Health Practices
- Prostate Cancer Diagnosis and Treatment
Walsall Healthcare NHS Trust
2022-2024
Kandahar University
2017-2024
University of Maryland, Baltimore
2024
Texas Tech University
2010-2024
Texas Tech University Health Sciences Center
2024
University of Swat
2023
Walsall Manor Hospital
2008-2021
Liaquat National Hospital
2020
Institute of Cancer Research
2017
Royal Marsden NHS Foundation Trust
2017
Prognosis of breast cancer and success therapeutic interventions largely rely on the clinico-pathologic biological characteristics tumor vary due to heterogeneous nature cancers. The aim this study was determine frequency prognostic parameters luminal cancers in our population devise targeted personalized regimens tailored needs loco-regional population. A retrospective cross-sectional including 1951 cases primary treated at Liaquat National Hospital Karachi conducted during year 2011–2016....
Abstract Objectives Ki67 is the most commonly used marker to evaluate proliferative index in breast cancer, however no cutoff values have been clearly defined for high ki67 index. Cancer management should be according loco-regional profile; therefore, we aimed determine 1951 cases of intrinsic cancer subtypes and its association with other prognostic parameters our set up. Results Triple negative cancers showed highest (mean 50.9 ± 23.7%) followed by Her2neu 42.6 21.6%) luminal B 34.9...
Abstract Metabolic and bariatric surgery (MBS) is widely considered the most effective option for treating obesity, a chronic, relapsing, progressive disease. Recently, American Society of Bariatric Surgery (ASMBS) International Federation Obesity Disorders (IFSO) issued new guidelines on indications MBS, which have superseded previous 1991 National Institutes Health guidelines. The aim this study to establish first set consensus selecting procedures in Class I II using an Expert Modified...
NAFLD has emerged as a significant global health problem since it impacts around 25 percent of people and strongly associates with metabolic syndrome. The development from simple hepatic steatosis through non-alcoholic steatohepatitis (NASH) eventually leads to fibrosis cirrhosis hepatocellular carcinoma. rising prevalence parallels the obesity epidemic, type 2 diabetes mellitus, insulin resistance, dyslipidemia, hypertension serving key risk factors. causes serious systemic problems beyond...
Epidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency over bladder cancer not studied our population; therefore we aimed evaluate the frequency prognostic significance EGFR immunohistochemical locoregional population. We performed immunohistochemistry on 126 cases association with tumor grade, lamina propria invasion, deep muscle invasion recurrence disease was evaluated. High noted...
p16 and p53 genes are frequently mutated in triple negative breast cancer & prognostic value of these mutations have been shown; however, their role as immunohistochemical overexpression has not fully validated. Therefore we aimed to evaluate the association with various parameters. Total 150 cases cancers were selected from records pathology department archives that underwent surgeries at Liaquat National hospital, Karachi January 2008 till December 2013. ER, PR Her2neu immunohistochemistry...
Immunohistochemical over expression of p53 is considered as a marker poor prognosis in many cancers. Therefore, we aimed to evaluate immunohistochemical overexpression 121 cases head and neck Squamous cell carcinoma its association with various clinicopathologic features survival. Total 66.1% (80 cases) expressed positive expression, 34% (29 revealed no while focal was noted 9.9% (12 Cases). Moreover, high (> 70%) 26.4% (32 cases), 19% (23 showed 51–70% expression. On the basis intensity...
The purpose of this study was to determine the frequency in-hospital mortality in 351 patients who developed cardiogenic shock after acute myocardial infarction and by determining this; we might find that how efficiently could manage serious condition our population knowing factors which are associated with high shock. Moreover impact early revascularization like thrombolytic therapy or angioplasty also evaluated. Mean age 65.41 ± 7.78 years study. In-hospital found be 44.73%. Significant...
In this study, we intend to determine the immunohistochemical expression of EGFR in cases head and neck squamous cell carcinoma its association with prognostic clinico-pathologic features. A total 115 treated at Liaquat National Hospital, Karachi, Pakistan, were included study. Clinico-pathologic features, risk factors, recurrence status evaluated, immunohistochemistry was performed. our 52 (45.2%) SCC positive 10 (8.7%) focal for expression, while 53 (46.1%) negative expression. High (>...
The aim of this study was to determine the frequency metaplastic breast carcinoma and invasive micropapillary in our population also compare clinico-pathologic features with ductal carcinoma, not otherwise specified (IDC, NOS). 86.9% cases were identified as NOS, while 2.2% 0.76% carcinoma. Metaplastic carcinomas found be higher grade compared IDC, NOS 81% III 35% NOS. 79% ER negative 86% PR negative, respectively which 40% 54% PR. Similarly, 86.7% cancers positive 73.3% positive. Moreover,...
Cytokeratin 5/6 and 8/18 are basal luminal markers of breast cancer they have pathological prognostic significance in cancer. We performed CK8/18 immunohistochemistry on 150 cases triple negative cancers association with various clinicopathological features was evaluated. Positive CK5/6 expression noted 8% (12 cases) TNBC while 2.4% (4 showed focal positive (< 10%) 89.3% (134) were CK5/6. Complete loss seen 4.7% (7 32.7% (49 revealed 62.7% (94 intact normal CK8/18. No significant parameters...
Well differentiated keratinized squamous component as a part of urothelial carcinoma can be easily appreciated; however non-keratinizing differentiation closely resembles differentiation. In addition prognostic significance CK 5/6 expression in the absence apparent is still unclear. Therefore, present study we aimed to evaluate frequency 127 cases and its loco-regional population. Positive CK5/6 was noted 6.3% (8 cases) 13.4% (17 revealed focal positive expression. On other hand, 80.3% (102...
Recent evidence suggests a role of androgen receptor expression as prognostic and therapeutic biomarker in endometrial carcinoma, therefore the present study we aimed to evaluate frequency different subtypes carcinoma its association with clinic-pathologic features. 18/89 (20.2%) cases showed positive expression. On other hand, low, moderate high was noted 7/89 (7.9%), 10/89 (11.2%) 1/89 (1.1%) respectively. 15/77 (19.48%) endometrioid cancers 3/7 (42.28%) serous expression; while none clear...
Conduction defects complicating acute myocardial infarction are frequently associated with increased morbidity and mortality. As frequency of this complication has not been widely studied in our population, therefore study we aimed to evaluate the complete atrioventricular block patients ST segment elevation its association other clinical parameters. The mean age was 50.55 ± 6.72 years at time MI. There were 147 (82.1%) males 32 (17.9%) females. 83 (46.4%) having hypertension, 61 (34.1%)...