A5091152168- Virus-based gene therapy research
- Animal Virus Infections Studies
- Wastewater Treatment and Nitrogen Removal
- Virology and Viral Diseases
- Advanced oxidation water treatment
- Water Treatment and Disinfection
- Microbial Fuel Cells and Bioremediation
- Kruppel-like factors research
- Membrane Separation Technologies
- interferon and immune responses
- Fibroblast Growth Factor Research
- Bacteriophages and microbial interactions
- Cancer Research and Treatments
- Microplastics and Plastic Pollution
- Epigenetics and DNA Methylation
- Antioxidants, Aging, Portulaca oleracea
- Ammonia Synthesis and Nitrogen Reduction
- Arsenic contamination and mitigation
- Recycling and Waste Management Techniques
- Constructed Wetlands for Wastewater Treatment
- Adsorption and biosorption for pollutant removal
- Immunotherapy and Immune Responses
- Environmental remediation with nanomaterials
- Biomedical Research and Pathophysiology
- Mine drainage and remediation techniques
Harbin Normal University
2022-2025
Harbin Institute of Technology
2019-2022
First Hospital of Shanxi Medical University
2021
Northeast Agricultural University
2013-2016
Life University
2014
Recombinant Newcastle disease virus (rNDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently clinical trials. In this study, we evaluated the possibility to enhance cancer potential of NDV by means inserting both interleukin-2 (IL-2) tumor necrosis factor-related apoptosis inducing ligand (TRAIL) delivered rNDV. We demonstrated that rNDV expressing TRAIL (rNDV-TRAIL) or human IL-2 (rNDV-IL-2-TRAIL) significantly enhanced inherent anti-neoplastic apoptosis....
Statins, a class of hyperlipidemic drugs, are widely used cholesterol lowering drugs that selectively inhibit 3hydroxy-3-methylglutaryl CoA reductase, which is the rate-limiting enzyme in biosynthesis, leading to decreasing biosynthesis.Statins exert anti-tumoral effects on various cancer, including breast cancer.However, molecular mechanisms for actions were not fully elucidated.The purpose this study was elucidate statins proliferation and apoptosis ER-negative cancer cell line...
Recombinant Newcastle Disease Virus (rNDV) has shown oncolytic therapeutic effect in preclinical studies. Previous data indicate that rNDV carrying IL2 promise cancer therapy. Due to the significant side effects of IL2, IL15 been introduced into A number studies have suggested efficiently enhances activities CTL and NK cells inhibits tumor recurrence metastasis. Furthermore, is less toxic than IL2. Therefore, we hypothesize a recombinant NDV expressing would be promising agent for treatment...
Rheumatoid arthritis (RA) is an autoimmune disease, primarily manifesting as inflammatory arthritis. It associated with chronic inflammation of the synovial joints, mostly in hands and feet, well systemic extra-articular inflammation. The chimeric anti-interleukin (IL)-17 full-length monoclonal antibody (CMa17Aab) targets IL-17A, which important cytokine pathogenesis RA other disorders. In this study, we investigated whether CMa17Aab exerts therapeutic effects a mouse model type II...
Recombinant Newcastle disease virus (rNDV) as antitumor agent has been shown to be effective for cancer therapy. And TNF-related apoptosis-inducing ligand (TRAIL) also demonstrated potentially cancer-therapeutic effects. In this study, we constructed TRAIL delivered by rNDV (rNDV-TRAIL) and investigated whether would generate the potential synergistic therapeutic effects with vitro experiments indicated that expressed good biological activity. significantly enhanced inducing apoptosis of in...
This study was conducted to investigate enhancement of anti-tumor effects the lentogenic Newcastle disease virus Clone30 strain (NDV rClone30) expressing cytosine deaminase (CD) gene against tumor cells and in murine groin tumor-bearing models. Cytotoxic rClone30-CD/5-FC on HepG2 cell line were examined by an MTT method. Anti-tumor activity H22 mice. Compared rClone30-CD treatment alone, NDV at 0.1 1 MOIs exerted significant cytotoxic (P<0.05) cells. For mice, recombinant injected together...
Abstract The purpose of this study was to investigate the treatment efficacy recombinant Rhodococcus erythropolis (RH) expressing hydroxylamine oxidase (HAO) and ammonia monooxygenase (AMO) genes (rRH‐HA) in removing nitrogen organic matter landfill leachate. Results demonstrated that rRH‐HA efficiently expressed HAO AMO during leachate aerobic system. Enhanced production increased pH control activity stability activated sludge (AS); decreased carbon source addition total (TOC), chemical...