A5070701026- Microbial Applications in Construction Materials
- Computational Drug Discovery Methods
- HIV/AIDS drug development and treatment
- Microbial Community Ecology and Physiology
- Genomics and Phylogenetic Studies
- Hepatitis C virus research
- Heat shock proteins research
- Trypanosoma species research and implications
- thermodynamics and calorimetric analyses
- Biochemical and Molecular Research
- Research on Leishmaniasis Studies
- Malaria Research and Control
University of Johannesburg
2021-2025
University of Cape Town
2024
University of the Free State
2019
Structure-activity relationship studies of 2,8-disubstituted-1,5-naphthyridines, previously reported as potent inhibitors
Abstract Malaria parasites use PfHGXPRT to convert 6‐oxopurine substrate bases their respective nucleotides, essential for parasite replication within the human host. Inhibitors targeting Pf HGXPRT may also bind homolog, Hs HGPRT due conserved active site residues. This lead unintended toxicity and side effects. To address this, we employed an in silico binding pocket workflow involving FTMap, FTSite, Protein Allosteric Regulatory Sites (PARS), Server (PaSSer) identify potential allosteric...
In an honors course on "Omics Sciences," draft genome sequences of Chryseobacterium elymi KCTC 22547T, flavum 12877T, hispanicum 22104T, lathyri 22544T, "Candidatus massiliae" CCUG 51329T, piscium 51923T, and rhizosphaerae 22548T were generated to facilitate phylogenomic comparisons within the genus.