A5021864441- Respiratory and Cough-Related Research
- Functional Brain Connectivity Studies
- Heart Rate Variability and Autonomic Control
- Neuroscience of respiration and sleep
- Advanced Neuroimaging Techniques and Applications
- Asthma and respiratory diseases
- Suicide and Self-Harm Studies
- Ion Channels and Receptors
- Neuroscience and Music Perception
- Neural dynamics and brain function
- Genetic Neurodegenerative Diseases
- Infant Health and Development
- Health and Medical Research Impacts
- Psychosocial Factors Impacting Youth
- Traumatic Brain Injury Research
- Noise Effects and Management
- Plant-Microbe Interactions and Immunity
- Mentoring and Academic Development
- Child and Adolescent Psychosocial and Emotional Development
- Neurological disorders and treatments
- Neurology and Historical Studies
- Cardiovascular Syncope and Autonomic Disorders
- Nicotinic Acetylcholine Receptors Study
- Schizophrenia research and treatment
- Biofield Effects and Biophysics
Heidelberg University
2017-2023
University Hospital Heidelberg
2022-2023
Heidelberg (Poland)
2022
Yamaguchi University
2022
The University of Queensland
2013-2019
The University of Melbourne
2014-2019
Orygen Youth Health
2017-2019
Florey Institute of Neuroscience and Mental Health
2010-2016
Monash University
2012-2014
Kanazawa University
1987
Chronic non-productive coughing is a major complication of pulmonary disease and can also occur in many individuals without identifiable underlying pathology. The common clinical link patients with cough an enhanced sensitivity the respiratory system to stimuli that subsequently evoke excessive coughing. aetiology this 'cough hypersensitivity syndrome' unclear but believed involve sensory neural pathways innervate airways lungs.In present study, we used functional brain imaging compare...
Excessive coughing is one of the most common reasons for seeking medical advice, yet available therapies treating cough disorders are inadequate. Humans can voluntarily cough, choose to suppress their and acutely aware an irritation that present in airways. This indicates a significant level behavioral conscious control over basic reflex pathway. However, very little known about neural basis higher brain regulation coughing. The aim study was use functional imaging healthy humans describe...
There is an overwhelming body of evidence to support the existence higher brain circuitries involved in sensory detection airways irritation and motor control coughing. The concept that cough purely a reflex response now superseded by recognition perception urge-to-cough altered behavioral modification coughing are key elements disorders associated with disease. Understanding pathways which airway nerves ascend into patterns neural activation will undoubtedly provide new insights disordered...
We used functional magnetic resonance imaging (fMRI) to investigate spatial working memory (WM) in an N–BACK task (0, 1, and 2‐BACK) premanifest Huntington's disease (pre‐HD, n = 35), early symptomatic (symp‐HD, 23), control ( 32) individuals. Overall, both WM conditions (1‐BACK activated a large network of regions throughout the brain, common all groups. However, voxel‐wise time‐course analyses revealed significant group differences, despite no behavioral performance differences. During...
Abstract Coughing and the urge‐to‐cough are important mechanisms that protect patency of airways, coordinated by brain. Inhaling a noxious substance leads to widely distributed network responses in brain likely reflect multiple functional processes requisite for perceiving, appraising, behaviorally responding airway challenge. The broader challenge contains subnetworks involved component functions required protective behaviors. Functional connectivity analyses were used determine whether...
Cough is important for airway defence, and studies in healthy animals humans have revealed multiple brain networks intimately involved the perception of irritation, cough induction suppression. Changes sensitivity and/or ability to suppress accompany pulmonary pathologies, suggesting a level plasticity possible these central neural circuits. However, little known about how persistent inputs from lung might modify processes regulating cough. In present study, we used human functional imaging...
Adolescence is a critical time for brain development. Findings from previous studies have been inconsistent, failing to distinguish the influence of pubertal status and aging on maturation. The current study sought address these inconsistencies, addressing trajectories development by longitudinally tracking structural during adolescence.Two cohorts healthy children were recruited (cohort 1: 9-10 years old; cohort 2: 12-13 old at baseline). MRI data acquired gray matter volume white tract...
Resting state heart rate variability (HRV) is a psychophysiological marker that has gained increasing research interest, in particular developmental neuroscience. HRV been shown to be associated with mental and physical health, beyond simple measures of (HR) shows inter- intraindividual variance across aging. Recently, three studies reported on positive correlation between resting cortical thickness selected regions interest (ROIs) adult samples. Structural thickness, HRV, HR change during...
Non-suicidal self-injury (NSSI) is a major mental health problem among youth worldwide. Dysfunction in emotion regulation contributes to NSSI, but research on the underlying neurobiological mechanisms of NSSI limited. Adolescents with difficulties are vulnerable stress, making them susceptible maladaptive coping such as NSSI. This study examined functional neurocircuitry relevant and stress individuals compared healthy controls. case-control included 34 adolescents (15.91 years) 28 (16.0...
Important neuropsychological changes during adolescence coincide with the maturation of white matter microstructure. Few studies have investigated association between development and longitudinally. We aimed to characterize developmental trajectories inhibition, planning, emotion recognition risk-taking examine whether microstructural characteristics were associated above beyond age. In an accelerated longitudinal cohort design, n = 112 healthy adolescents ages 9 16 underwent cognitive...
Adolescence is a crucial period for both brain maturation and the emergence of mental health disorders. Associations between morphology internalizing/externalizing symptomatology have been identified in clinical or at-risk samples, but age-related developmental differences were rarely considered. The current study investigated longitudinal relationship symptoms development absence psychiatric disorders during early late adolescence. 98 healthy adolescents within two cohorts (younger: 9...
Supramedullary brain regions may contribute to control of cough by facilitating or inhibiting brainstem reflex pathways. Using functional imaging, we put this putative model the test. Blood oxygen level‐dependent (BOLD) contrast images were acquired from 15 healthy subjects after inhaling saline, capsaicin without cough, with and voluntary saline. BOLD signals analysed identify changes associated stimulation their interactions. Contrary hypothesised effect, positive interaction did not...