A5037626179- Cancer Genomics and Diagnostics
- Hepatitis C virus research
- Hemoglobinopathies and Related Disorders
- Viral-associated cancers and disorders
- Hepatitis B Virus Studies
- Genomics and Chromatin Dynamics
- Multiple Myeloma Research and Treatments
- Hemoglobin structure and function
- Protein Degradation and Inhibitors
- Erythrocyte Function and Pathophysiology
- Melanoma and MAPK Pathways
- Prenatal Screening and Diagnostics
- Epigenetics and DNA Methylation
Prince of Wales Hospital
2016-2024
Chinese University of Hong Kong
2016-2024
The analysis of tissues origin cell-free DNA (cfDNA) is research and diagnostic interest. Many studies focused on bisulfite treatment or immunoprecipitation protocols to assess the cfDNA. loss often occurs during such processes. Fragmentomics cfDNA molecules has uncovered a wealth information related There still much room for development tools assessing contributions from various into plasma using fragmentomic features. Hence, we developed an approach analyze relative different plasma, by...
Abstract The tissues of origin plasma DNA can be revealed by methylation patterns. However, the relative contributions from megakaryocytes and erythroblasts into appeared inconsistent among studies. To shed light this phenomenon, we developed droplet digital PCR (ddPCR) assays for differential detection these cell types in based on megakaryocyte-specific erythroblast-specific markers. Megakaryocytic erythroid contributed a median 44.2% 6.2% healthy individuals, respectively. Patients with...
Hb Tarrant [α126(H9)Asp→Asn; HBA2: c.379G > A (or HBA1)], is a rare high oxygen affinity hemoglobin (Hb) variant that causes erythrocytosis, previously described in few Mexican–American families. Here we report the first Chinese family with this presenting unexplained familial erythrocytosis. No evidence of hemolysis was seen. locally adapted approach to diagnostic process clinical laboratories discussed. Molecular analysis has an important role confirmation diagnosis. Proper identification...