A5067998201- Neuroscience and Neuropharmacology Research
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Hormonal Regulation and Hypertension
- Genetic Neurodegenerative Diseases
- Receptor Mechanisms and Signaling
- Signaling Pathways in Disease
- Extracellular vesicles in disease
- Microtubule and mitosis dynamics
- Memory and Neural Mechanisms
- Immune cells in cancer
- Diet and metabolism studies
- Tryptophan and brain disorders
University of Derby
2024
Queen's Medical Centre
2015-2020
University of Nottingham
2013-2020
CDK12 inhibition reduces mutant transcripts and nuclear foci in DM1 cells produces splicing correction phenotypic benefit a mouse model.
NAD metabolism and the biosynthetic enzymes nicotinamide nucleotide adenylyltransferases (NMNATs) are thought to play a key neuroprotective role in tauopathies, including Alzheimer's disease. Here, we investigated whether modulating expression of NMNAT nuclear isoform NMNAT1, which is important for neuronal maintenance, influences development behavioral neuropathological abnormalities htau mice, express non-mutant human tau isoforms represent model tauopathy relevant Prior cognitive...
Metabolite profiling is an important tool that may better capture the multiple features of neurodegeneration. With considerable parallels between mouse and human metabolism, use metabolomics in models with neurodegenerative pathology provides mechanistic insight ready translation into aspects disease. Using 400 MHz nuclear magnetic resonance spectroscopy we have carried out a temporal region-specific investigation metabolome neuron-specific 26S proteasome knockout mice characterised by...
Neurodegenerative diseases have become a “hot” topic in recent years. A major factor for this is that as life expectancy of the population developed countries increases, so does probability developing neurodegenerative disorders such Alzheimer’s disease (AD) and Parkinson’s (PD), to name two most well-known. In many cases, however, neurological mental are poorly understood. particular, there lack specific biomarkers which would allow early unambiguous identification disease, distinguishing...
Extracellular vesicles (EVs) are secreted by all cells in the CNS, including neurons and astrocytes. EVs lipid membrane enclosed particles loaded with various bioactive cargoes reflecting dynamic activities of origin. In contrast to neurons, specific role released astrocytes is less well understood, partly due difficulty maintaining primary astrocyte cultures a quiescent state. The aim this study was establish human serum-free culture system that maintains state morphology, function, protein...