A5011918683- Hearing Impairment and Communication
- Language, Discourse, Communication Strategies
- Language, Metaphor, and Cognition
- Circadian rhythm and melatonin
- Tracheal and airway disorders
- Syntax, Semantics, Linguistic Variation
- Axon Guidance and Neuronal Signaling
- Dysphagia Assessment and Management
- Esophageal and GI Pathology
- Neurobiology of Language and Bilingualism
- Free Radicals and Antioxidants
- Hand Gesture Recognition Systems
- Pluripotent Stem Cells Research
- Child and Animal Learning Development
- Growth Hormone and Insulin-like Growth Factors
- Angiogenesis and VEGF in Cancer
- Neurobiology and Insect Physiology Research
- COVID-19 Clinical Research Studies
- Lysosomal Storage Disorders Research
- Natural Language Processing Techniques
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Phagocytosis and Immune Regulation
- Categorization, perception, and language
Walter and Eliza Hall Institute of Medical Research
2022-2024
Harvard University Press
2016-2024
Monash University
2019-2024
Harvard University
2015-2024
The University of Melbourne
2014-2024
Breast Cancer Now
2022
Institute of Cancer Research
2022
Boston Children's Hospital
2017-2021
Quantitative BioSciences
2021
Language Science (South Korea)
2021
Bilingualism is common throughout the world, and bilingual children regularly develop into fluently adults. In contrast, with cochlear implants (CIs) are frequently encouraged to focus on a spoken language exclusion of sign language. Here, we investigate English skills 5 CIs who also have deaf signing parents, so receive exposure full natural (American Sign Language, ASL) from birth, in addition after implantation. We compare their hearing ASL/English parents. Our results show comparable...
Kallmann syndrome (KS) is a genetic disease characterized by hypogonadotropic hypogonadism and impaired sense of smell. The causes underlying this are still largely unknown, but thought to be due developmental defect in the migration gonadotropin-releasing hormone (GnRH) neurons. Understanding hampered lack appropriate mouse models. GnRH neurons hypothalamic cells that centrally control reproduction mammals secreting decapeptide into portal blood vessels pituitary stimulate production...
Neuropilin 1 (NRP1) is a transmembrane glycoprotein that essential for blood vessel development in vertebrates. Best known its ability to bind members of the vascular endothelial growth factor (VEGF) and class 3 semaphorin families through extracellular domain, it also has highly conserved cytoplasmic which terminates SEA motif binds PDZ protein synectin/GIPC1/NIP. Previous studies zebrafish embryos tissue culture models raised possibility NRP1 angiogenesis. Here, we describe generation mice...
Individuals with an inherited deficiency in gonadotropin-releasing hormone (GnRH) have impaired sexual reproduction. Previous genetic linkage studies and sequencing of plausible gene candidates identified mutations associated GnRH deficiency, but the small number affected families limited success validating impeded diagnoses for most patients. Using a combination exome computational modeling, we shared point mutation semaphorin 3E (SEMA3E) 2 brothers Kallmann syndrome (KS), which causes...
Abstract Necroptosis, a type of lytic cell death executed by the pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) has been implicated in detrimental inflammation caused SARS-CoV-2 infection. We minimally and extensively passaged single clinical isolate to create models mild severe disease mice allowing us dissect role necroptosis pathogenesis. infected wild-type MLKL-deficient found no significant differences viral loads or lung pathology. In our model COVID-19, MLKL-deficiency did not...
In American Sign Language (ASL), conjunction ('and') and disjunction ('or') are often conveyed by the same general use coordinator (transcribed as "COORD"). So sequence of signs MARY WANT TEA COORD COFFEE can be interpreted 'Mary wants tea or coffee' depending on contextual, prosodic, other lexical cues. This paper takes first steps in describing syntax semantics two coordinators ASL, finding that they have a similar syntactic distribution to English or. Semantically, arguments made against...
The diversity of COVID-19 disease in otherwise healthy people, from seemingly asymptomatic infection to severe life-threatening disease, is not clearly understood. We passaged a naturally occurring near-ancestral SARS-CoV-2 variant, capable infecting wild-type mice, and identified viral genomic mutations coinciding with the acquisition young adult mice lethality aged animals. Transcriptomic analysis lung tissues elucidated host antiviral response dominated mainly by interferon IL-6 pathway...
Gonadotropin-releasing hormone (GnRH) neurons are neuroendocrine cells that born in the nasal placode during embryonic development and migrate through nose forebrain to hypothalamus, where they regulate reproduction. Many molecular pathways guide their migration have been identified, but little is known about factors control survival of migrating GnRH as negotiate different environments. We previously reported class 3 semaphorin SEMA3A signals its neuropilin receptors, NRP1 NRP2, organise...
Morquio A (Mucopolysaccharidosis IVA; MPS IVA) is an autosomal recessive lysosomal storage disorder caused by partial or total deficiency of the enzyme galactosamine-6-sulfate sulfatase (GALNS; also known as N-acetylgalactosamine-6-sulfate sulfatase) encoded GALNS gene. Patients who inherit two mutated gene alleles have a decreased ability to degrade glycosaminoglycans (GAGs) keratan sulfate and chondroitin 6-sulfate, thereby causing GAG accumulation within lysosomes consequently pleiotropic...
The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with vertebrae. This co-patterning set up during embryogenesis, when vertebrae develop from sclerotome layer metameric somites, and PNS neurons glia differentiate neural crest cells (NCCs) that preferentially migrate into anterior halves. Previous analyses mice deficient in class 3 semaphorin (SEMA3) receptors neuropilin (NRP) 1 or 2 raised possibility each controlled a distinct aspect...
A construction is found in American Sign Language that we call a Question–Answer Clause. It made of two parts: the first part looks like an interrogative clause conveying question, while second resembles declarative answering question. The very same signer has to sign both, entire interpreted as truth-conditionally equivalent sentence, and it can be uttered only under certain discourse conditions. These other properties Clauses are discussed, detailed syntactic, semantic, pragmatic account...
ABSTRACT Objectives: To determine if children with laryngeal penetration on videofluoroscopic swallow study (VFSS) who received feeding interventions (thickened liquids, change in liquid flow rate, and/or method of delivery) had improved symptoms and decreased hospitalizations compared those without intervention. Methods: We performed a retrospective cohort under 2 years VFSS at our institution 2015 to initial follow‐up findings, symptom improvement follow‐up, hospitalization risk before...
Laryngomalacia is the most common laryngeal anomaly and commonly associated with stridor in children, but recurrent respiratory and/or feeding difficulties this condition may pose a threat to well-being of affected child.To describe prevalence aspiration pediatric patients laryngomalacia who present issues difficulty.This retrospective review medical records involved 142 patients. These received diagnosis, presented difficulties, underwent modified barium swallow (MBS) study at tertiary...
Abstract: Insomnia, which is severe enough to warrant treatment, occurs in ∼10% of the general population. It associated with a range adverse consequences for human health, economic productivity and quality life. In animal studies, administration melatonin has been reported promote sleep, although there controversy regarding its effectiveness. The present study used chronically implanted radiotelemetry transmitter record electroencephalogram (EEG) electromyogram (EMG) enable discrimination...
Objectives/Hypothesis To describe the prevalence of aspiration in children with unilateral vocal fold paralysis who underwent objective assessment swallow function. Study Design Retrospective chart review. Methods A study patients presenting to our institution 2015 was conducted. All were diagnosed using flexible laryngoscopy. Patients included if they at least one modified barium (MBS) for evaluation their swallowing function due recurrent respiratory issues and/or feeding difficulty....
The semantics of adjective modification often begins with set intersection,such that [[yellow flower]] = [[yellow]] ∩ [[flower]]. Thus a yellow flower is flower. Such an account, however, runs into problems for adjectives like fake or counterfeit, which display privative inference: gun not and counterfeit dollar dollar. Moreover, recent work shows privativity cannot easily be encoded as property specific since e.g. watch robustly licenses the subsective inference being (Martin 2022). We...