Abstract We aimed to estimate the incidence, mortality, and disability-adjusted life-years (DALYs) of stomach cancer at global, regional, national levels. Stomach resulted in 1.3 million (1.2–1.4 million) incident cases, 9.5 hundred thousand (8.7–10.4 thousand) deaths, 22.2 (20.3–24.1 DALYs 2019. The age-standardized incidence rate, death rate DALY were 15.6 (14.1–17.2), 11.9 (10.8–12.8), 268.4 (245.5–290.6) per 100,000 person-years, respectively. Between 1990 2019, global decreased by −...

<h3>Objective</h3>To evaluate the long-term efficacy of bilateral endoscopic vidian neurectomy in management moderate to severe persistent allergic rhinitis.<h3>Design</h3>A prospective reassessment postoperative results using Rhinoconjunctivitis Quality Life Questionnaire and visual analog scale for patients with rhinitis.<h3>Setting</h3>University hospital.<h3>Patients</h3>A total 236 rhinitis were divided into following 3 treatment groups: those who underwent (group 1, n = 93), partial...

Abstract We aim to report the latest incidence, mortality, and disability‐adjusted life‐years (DALYs) between 1990 2019, by age, sex, sociodemographic index (SDI), provide predictions 2035. use estimates from Global Burden of Disease, Injuries, Risk Factors Study 2019 analyze DALYs. All were shown as counts age‐standardized rates (ASR). In there more than 176,501 (156,046 199,917) incidence cases, with ASRs 2.1 (1.9 2.4). Nasopharyngeal cancer (NPC) accounted for 71,610 (65,442 77,625)...

We aim to report the incidence, mortality and disability-adjusted life years (DALYs) between 1990 2019 provide predictions 2035.We use estimates from Global Burden of Disease, Injuries Risk Factors Study analyse DALYs.In 2019, there were more than 209,149 incidence cases, with age-standardised rates (ASRs) 2.5. Laryngeal cancer accounted for 123,356 death ASRs 1.5. was also responsible 3.26 million (3,034,634 3,511,354) DALYs, 38.8 (36.1 41.8). In Central Europe had highest rate. At national...

Objective. The aim of the study is to provide burden cutaneous squamous cell carcinoma (cSCC) in 21 regions, 204 countries, and territories from 1990 2019 by age, sex, sociodemographic index (SDI) predict global cSCC 2035. Methods. We use estimates Global Burden Disease (GBD) conduct analysis prediction. was estimated for 2019, through a systematic incidence, death, disability adjusted life years (DALYs) modelled data using methods reported GBD study. predicted age-standardized incidence...

We aimed to analyze the global trends in burden of blindness and vision loss caused by type 2 diabetes from 1990 2050. Based on Global Burden Disease Study (GBD) 2021, prevalence years lived with disability (YLD) were analyzed age, sex, socio-demographic index (SDI) for 204 countries territories projections future 2021 There 5694156 (4498190–7112643) numbers 459976 (304429–661417) YLDs due at level 2021. The age-standardized rate was 65.7 (52.2–82), YLD 5.3 (3.5–7.6) all which exhibited...

The global epidemiological data on congenital hearing loss in children is sparse. We aimed to analyse the trends burden of complete caused by birth defects younger than five years from 1990 2030.Using Global Burden Disease (GBD) Study 2019, we reported counts and rates prevalence lived with disability (YLD) age, sex, sociodemographic index (SDI). also forecasted until 2030 through autoregressive integrated moving average (ARIMA) Bayesian age-period-cohort (BAPC) models.We observed a rate...

Head and neck squamous cell cancer (HNSCC) is a common malignant cancer. We aimed to explore prognostic cuproptosis-related lncRNAs (CRLs) risk models for HNSCC.The transcriptome profiles clinical data were obtained from the TCGA database, 19-cuproptosis-related genes (CRGs) acquired previous studies. Then, model based on seven CRLs was established. analysed its value evaluate prognosis, drug sensitivity, tumour immune functions of patients with HNSCC. Finally, we used quantitative reverse...

Hemorrhage within the ethmoid and/or sphenoid sinus and an interval between time of injury operation exceeding 3 days are risk factors for visual prognosis traumatic blindness.To investigate therapeutic efficacy endoscopic optic nerve decompression in treatment blindness to evaluate relevant prognostic factors.Eighty-five cases were analyzed retrospectively. Univariate analysis multiple logistic regression performed potential factors.The overall rate vision acuity improvement was 44.7% (38...

Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase cell cycle and trigger apoptosis. To investigate apoptosis induced paclitaxel nasopharyngeal carcinoma (NPC), possible molecular mechanism action, human NPC lines HNE-1 (bearing wild-type p53) CNE-2 mutant were treated with different concentrations paclitaxel. Apoptosis was determined staining propidium iodide also DNA fragmentation. Protein expression levels p53, bcl-2 bcl-xl...

Taxol is a first-line chemoagent used for treatment of nasopharyngeal carcinoma (NPC). A major obstacle to achieving successful the development cellular taxol drug resistance. Aberrant DNA methylation has been recognized be associated with transcriptional inactivation genes related cancer resistance development. To identify mechanism involved in NPC resistance, we applied genome-wide microarray assay reveal alteration taxol-resistant cell lines (CNE-1/taxol, 5-8F/taxol, HNE-2/taxol)...

Objective To further determine the role of FOLR1 in taxol resistance nasopharyngeal carcinoma (NPC) and whether inhibition expression reverses taxol‐resistant phenotype. Study Design Correlation study between gene cancer cell survival. Setting University hospital. Subjects Methods Three sub–cell lines with a different resistant index were established from parental CNE‐1 NPC line. The correlation sensitivity was statistically analyzed. Inhibition carried out by RNA interference FOLR1‐specific...

Conclusions: The endoscopic endonasal transsphenoidal approach can be a choice for sellar tumors beyond the turcica, but it is necessary to make carefully because of severe surgical risks. Objectives: To summarize our experience removal turcica via and evaluate efficacy complications. Methods: Between January 2007 2012, 30 patients with underwent surgery using approach. Results: Postoperative pathological examination demonstrated that pituitary adenoma occurred in 22 patients,...

OBJECTIVE Genomic instability reflecting the susceptibility of genome to acquire multiple genetic alterations plays a major role in tumorigenesis and tumor progression. We evaluated prognostic significance extent genomic nasopharyngeal carcinoma. STUDY DESIGN AND SETTING was assessed by inter—simple sequence repeats polymerase chain reaction (inter‐SSR PCR) 38 patients with Characterization verification band shared different tumors were carried out sequencing nest PCR. RESULTS 31 (81.6%)...