Modulation with the suppression of infection and inflammation is essential to successful treatment periodontitis. An aqueous insoluble hydrophobic anti-inflammatory compound, i.e., ibuprofen (IBU), was investigated in this study as matrix-forming agent a doxycycline hyclate (DH)-loaded solvent removal-induced situ forming gel (ISG) using dimethyl sulfoxide (DMSO) N-methyl pyrrolidone (NMP) solvents. Their physicochemical properties, including pH, density, viscosity, surface tension, contact...

Currently, the application of solvent exchange-induced in situ gel is underway for drug delivery to body target site. Nitrocellulose was attempted this research as matrix-forming agent acne and periodontitis treatments. The incorporated a combination 1% w/w levofloxacin HCl 2% salicylic acid active compounds. In order facilitate formulation development, study explored behavior different concentrations nitrocellulose N-methyl pyrrolidone (NMP). Consequently, their physicochemical properties...

Polymeric material plays an important role as a matrix former in the modulation of drug release antimicrobial-loaded

Azithromycin (AZM) is a potential antimicrobial drug for periodontitis treatment. However, sustained-release system needed intra-periodontal pocket delivery. This study focused on the development and evaluation of thermoresponsive azithromycin-loaded niosome gel (AZG) to search desirable formulation AZG was further developed from an AZM-loaded niosomal by exploiting advantages poloxamer 407 (P407) hyaluronic acid (HA) interactions. The results showed that addition HA decreased gelation...

Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is effective periodontitis treatment. The aqueous insoluble property of rosin suitable for preparing a solvent exchange-induced gel. This study aims to investigate the role incorporating lime peel oil (LO) on physicochemical properties gels based loaded with 5% w/w doxycycline hyclate (DH) dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone (NMP). Their formation, viscosity, injectability, mechanical...

Vancomycin hydrochloride (HCl) is a glycopeptide antibiotic used to treat serious or life-threatening infections, and it reduces plaque scores gingivitis in periodontal patients. In this study, vancomycin HCl was incorporated into rosin situ forming gel (ISG) microparticles (ISM) generate local drug delivery system disease. The physical properties of the ISG ISM were measured, including pH, viscosity, injectability, adhesion properties, in-vitro transformation, release. Moreover,...

In recent years, the world has faced issue of antibiotic resistance. Methicillin-resistant Staphylococcus aureus (MRSA) is a significant problem in various treatments and control infections. Biocompatible materials with saturated fatty acids different chain lengths (C8-C18) were studied as matrix formers localized injectable vancomycin HCl (VCM)-loaded antisolvent-induced situ forming matrices. The series acid-based matrices showed low viscosity (5.47-13.97 cPs) pH value range 5.16-6.78,...

Zein is composed of nonpolar amino acids and a water-insoluble protein used as the matrix-forming agent localized in situ forming gel (ISG). Therefore, this study prepared solvent removal phase inversion zein-based ISG formulations to load levofloxacin HCl (Lv) for periodontitis treatment using dimethyl sulfoxide (DMSO) glycerol formal (GF) solvents. Their physicochemical properties were determined, including viscosity, injectability, formation, drug release. The topography dried remnants...

A drug delivery system based on an aqueous-induced in situ forming gel (ISG) consists of solubilizing the within organic solution a polymer using biocompatible solvent. Upon contact with aqueous medium, solvent diffuses out and polymer, designed to be insoluble water, solidifies transforms into gel. Nitrocellulose (Nc), nitrated ester cellulose, should promising for ISG water induction its state via phase inversion. The aim this investigation was develop evaluate moxifloxacin HCl...

The purpose of this study is to fabricate the polyethylene glycol matrix tablet by mold technique. Indomethacin and hydroxypropylmethylcellulose were used as model drug polymer, respectively, in PEG system. physical release characteristics developed studied. This inert carrier system comprising 7:3 4000: 400 could effectively enhance solubility indomethacin an addition sustain release. Scanning electron microscope photomicrograph indicated diffusion outward through porous network into...

The crabapple mangrove tree, Sonneratia caseolaris Linn. (Family: Sonneratiaceae), is one of the foreshore plants found in estuarine and tidal creek areas forests. Bark fruit extracts from this plant have previously been shown to an anti-oxidative or cytotoxic effect, whereas flower exhibited antimicrobial activity against some bacteria. According traditional folklore, it medicinally used as astringent antiseptic. Hence, investigation was carried out on extract leaves, pneumatophore...

Eutectic system is a mixture or solution which the ingredients solidify liquefy simultaneously. A eutectic therefore that unique composition of two (or more) components has lower crystallization temperature melting point. This aim this study was to prepare and characterize systems containing menthol, borneol, camphor N -Ethyl-5-methyl-2-(1-methylethyl) cyclohexanecarboxamide (WS-3). Menthol able form liquid at room with in ratio 8:2, 7:3, 6:4 5:5 whereas menthol borneol 8:2 WS-3 1:1. The...

Solvent exchange-induced in situ forming gel (ISG) has emerged as a versatile drug delivery system, particularly for periodontal pocket applications. In this study, we developed lincomycin HCl-loaded ISGs using 40% borneol-based matrix and N-methyl pyrrolidone (NMP) solvent. The physicochemical properties antimicrobial activities of the were evaluated. prepared exhibited low viscosity reduced surface tension, allowing easy injection spreadability. Gel formation increased contact angle on...

Solvent exchange-induced in situ forming gel (ISG) is currently an appealing dosage form for periodontitis treatment via localized injection into the periodontal pocket. This study aims to apply Eudragit L and S as matrix components of ISG by using monopropylene glycol a solvent loading levofloxacin HCl treatment. The influence concentration was investigated terms apparent viscosity, rheological behavior, injectability, gel-forming mechanical properties. L-based formulation presented less...

Gel layer characteristics play a crucial role in hydrophilic hydroxypropyl methylcellulose (HPMC) matrix development. Effervescent agents have the potential to affect gel microstructures. This study aimed investigate influence of effervescence on microstructure around HPMC matrices using combination texture analysis and imaging techniques. The relationship with drug release profile mechanisms were also examined. high amounts effervescent promoted rapid carbonation reaction, resulting...