A5027338301- Antifungal resistance and susceptibility
- Cardiac pacing and defibrillation studies
- Fungal Infections and Studies
- Gut microbiota and health
- Cardiac Structural Anomalies and Repair
- Vector-borne infectious diseases
- Salivary Gland Disorders and Functions
- Bacillus and Francisella bacterial research
- Oral microbiology and periodontitis research
- Yersinia bacterium, plague, ectoparasites research
- Antibiotic Use and Resistance
- Fungal Plant Pathogen Control
- Peptidase Inhibition and Analysis
- Inflammatory Bowel Disease
- Pain Management and Treatment
- Plant Pathogens and Fungal Diseases
- Urinary Tract Infections Management
- Botulinum Toxin and Related Neurological Disorders
- Viral Infections and Immunology Research
- Tuberculosis Research and Epidemiology
- Fungal and yeast genetics research
- Mycotoxins in Agriculture and Food
- Infective Endocarditis Diagnosis and Management
- Helminth infection and control
- Cardiac Arrhythmias and Treatments
Khalifa University of Science and Technology
2023
The University of Texas Health Science Center at San Antonio
2014-2021
University of Sharjah
2018-2020
Drexel University
2009-2013
Catholic Medical Center
2013
Mercy Catholic Medical Center
2013
Hahnemann University Hospital
2010
Azole resistance in Aspergillus fumigatus is an increasing problem. The TR34 L98H and TR46 Y121F T289A mutations that can occur patients without previous azole exposure have been reported Europe, Asia, the Middle East, Africa, Australia. Here, we report detection of both confirmed A. isolates collected institutions United States. These mutations, other known to cause resistance, MICs are here.
Systemic interactions between distant organs, such as the oral-brain axis, remain largely unknown. This study aimed to shed light on a specific aspect of these interactions, by focusing brain, in form psychological traits, oral microbiome, and metabolism (BMM) with respect influence smoking microbiota. We analyzed three datasets covering microbiome composition, metabolic pathways smokers non-smokers. used Canonical Correlation Analysis (CCA) reduce dimensionality different into scalar...
ABSTRACT Candida albicans , a major human fungal pathogen, is the primary cause of invasive candidiasis in wide array immunocompromised patients. C. virulence requires ability to undergo reversible morphological transition from yeast filaments response variety host environmental cues. These cues are sensed by pathogen and activate multiple signal transduction pathways induce filamentation. Reversible phosphorylation events critical for regulation many these pathways. While protein kinases...
Significant interlaboratory variability is observed in testing the caspofungin susceptibility of Candida species by both CLSI and EUCAST broth microdilution methodologies. We evaluated influence treated versus untreated polystyrene microtiter trays on MICs using 209 isolates four species, including 16 C. albicans 11 glabrata with defined FKS mutations. Caspofungin were also determined commercially available YeastOne Etest assays 102 isolates. All had ≥0.5 μg/ml, clinical breakpoint for...
Background Percutaneous extraction of standard implantable cardioverter‐defibrillator leads is often complicated by ingrowth fibrotic tissue into the shocking coils. Leads with GORE™ expanded polytetrafluoroethylene (ePTFE) coating (W. L. Gore & Associates, Inc., Newark, DE, USA) designed to inhibit fibrosis are in use, but clinical data regarding their lacking. The study's purpose was examine feasibility, efficacy, and safety percutaneous involving defibrillator coated ePTFE. Methods We...
Background: Endocarditis is a potentially lethal complication of implantation cardioverter–defibrillator (ICD). Methods: We report the case 62-year-old male with candidemia and vegetation from large implantable ICD lead that could not be extracted percutaneously. The system was completely successfully removed through pocket re-exploration sternotomy cardiopulmonary bypass. Results: Although patient considered at high risk thrombocytopenia, systemic infection, symptomatic heart failure very...
Despite the maintenance of YopP/J alleles throughout human-pathogenic Yersinia lineage, benefit YopP/J-induced phagocyte death for pathogenesis in animals is not obvious. To determine how sequence divergence has impacted virulence, we examined protein polymorphisms this type III secreted effector across 17 species and tested consequences polymorphism a murine model subacute systemic yersiniosis.
Abstract Background: Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution oral microbiota remain unknown these Methods: We evaluated composition capabilities with relation to cigarette smoking 105 adults through shotgun metagenomics using buccal swabs. Results: our study subjects was dominated by phyla Firmicutes , Proteobacteria Actinobacteria...
Abstract Background: Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution oral microbiota remain unknown these Methods: We evaluated composition capabilities with relation to cigarette smoking 105 adults through shotgun metagenomics using buccal swabs. Results: our study subjects was dominated by phyla Firmicutes , Proteobacteria Actinobacteria...
Abstract Despite the maintenance of YopP/J alleles throughout human-pathogenic Yersinia lineage, benefit YopP/J-induced phagocyte death for pathogenesis in animals is not obvious. To determine how sequence divergence has impacted virulence, we examined protein polymorphisms this Type III secreted effector across 17 species, and tested consequences polymorphism a murine model sub-acute systemic yersiniosis. Our evolutionary analysis revealed that codon 177 been subjected to positive selection...