A5070534033- Hepatocellular Carcinoma Treatment and Prognosis
- Advanced Radiotherapy Techniques
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Blood properties and coagulation
- Nanoplatforms for cancer theranostics
- Radiation Therapy and Dosimetry
- Breast Cancer Treatment Studies
- Radiation Dose and Imaging
- Pancreatic and Hepatic Oncology Research
- Optical Imaging and Spectroscopy Techniques
- Retinal Imaging and Analysis
- Immune cells in cancer
- Radiopharmaceutical Chemistry and Applications
- Photodynamic Therapy Research Studies
- Liver Disease and Transplantation
- Ophthalmology and Visual Impairment Studies
- Angiogenesis and VEGF in Cancer
- Cancer, Stress, Anesthesia, and Immune Response
- Endometrial and Cervical Cancer Treatments
- Reproductive tract infections research
- AI in cancer detection
- Cancer Genomics and Diagnostics
- Microfluidic and Bio-sensing Technologies
Duke University
2019-2024
Tulane University
2017-2021
Abstract Laser surgery is a rising surgical technique, which offers several advantages compared to the traditional scalpel. However, laser lacks contact-free feedback system high imaging contrast identify tissue type ablated and also penetration depth. Photoacoustic has potential fill this gap. Since photoacoustic detection commonly contact based, new non-interferometric technique based on speckle-analysis for remote presented in work. Phantom ex-vivo experiments are carried out transmission...
Objective: Ethanol ablation, the injection of ethanol to induce necrosis, was originally used treat hepatocellular carcinoma, with survival rates comparable surgery. However, efficacy is limited due leakage into surrounding tissue. To reduce leakage, we previously reported incorporating ethyl cellulose (EC) as this mixture forms a gel when injected further develop EC-ethanol an ablative therapy, present study evaluates extent which salient parameters govern fluid distribution. Methods:...
Focal tumor ablation with ethanol could provide benefits in low-resource settings because of its low overall cost, minimal imaging technology requirements, and acceptable clinical outcomes. Unfortunately, is not commonly utilized a lack predictability the zone, caused by inefficient retention at injection site. To create predictable zone ablation, we have developed polymer-assisted method using ethyl cellulose (EC) mixed ethanol. EC ethanol-soluble water-insoluble, allowing for EC-ethanol to...
Triple-negative breast cancer (TNBC) is an immunologically heterogenous disease that lacks clinically actionable targets and more likely to progress metastatic than other types of cancer. Tumor ablation has been used increase response rates checkpoint inhibitors, which remain low for TNBC patients. We hypothesized tumor could produce anti-tumor without using inhibitors if immunosuppression (i.e., Tregs, acidosis) was subdued. Tumors were primed with sodium bicarbonate (200 mM p.o.) reduce...
Ethanol provides a rapid, low-cost ablative solution for liver tumors with small technological footprint but suffers from uncontrolled diffusion in target tissue, limiting treatment precision and accuracy. Incorporating the gel-forming polymer ethyl cellulose to ethanol localizes distribution. The purpose of this study was establish non-invasive methodology based on CT imaging quantitatively determine relationship between delivery parameters EC-ethanol formulation, its distribution,...
Abstract In low-income countries, up to 80% of women diagnosed with cervical dysplasia do not return for follow-up care, primarily due treatment being inaccessible. Here, we describe development a low-cost, portable suitable such settings. It is based on injection ethyl cellulose (EC)-ethanol ablate the transformation zone around os, site most impacted by dysplasia. EC polymer that sequesters ethanol within prescribed volume when injected into tissue, and this modulated delivery parameters...
Approximately 10% of the lowercase text on nonprescription drug labels is smaller than 1 mm required by Food and Drug Administration. The small size, combined with progressive decline in accommodative amplitude gain, poses a reading challenge for middle-aged emerging presbyopes.The purpose this study was to evaluate impact progressing presbyopia near adds ability patients read routinely encountered product labels.Geometrical optics used determine changing viewing distance, accommodation,...
Ethanol ablation is a minimally invasive, cost-effective method of destroying tumor tissue through an intratumoral injection high concentrations cytotoxic alcohol. Ethyl-cellulose ethanol (ECE) ablation, modified version contains the phase-changing polysaccharide ethyl-cellulose to reduce leakage away from tumor. Ablation produces necrosis and initiates wound healing process; however, characteristic immunologic events after ECE tumors has yet be explored. Models triple-negative breast cancer...
Ethyl cellulose–ethanol (ECE) is emerging as a promising formulation for ablative injections, with more controllable injection distributions than those from traditional liquid ethanol. This study evaluates the influence of salient parameters on forces needed infusion, depot volume, retention, and shape in large animal model relevant to human applications. Experiments were conducted investigate how infusion volume (0.5 mL 2.5 mL), ECE concentration (6% or 12%), needle gauge (22 G 27 G), rate...
Abstract Focal tumor ablation with ethanol could provide benefits in low-resource settings because of its low overall cost, minimal imaging technology requirements, and acceptable clinical outcomes. Unfortunately, is not commonly utilized a lack predictability the zone, caused by inefficient retention at injection site. To create predictable zone ablation, we have developed polymer-assisted method using ethyl cellulose (EC) mixed ethanol. EC ethanol-soluble water-insoluble, allowing for...
Abstract Purpose Ethanol provides a rapid, low-cost ablative solution for liver tumors with small technological footprint but suffers from uncontrolled diffusion in target tissue, limiting treatment precision and accuracy. The authors demonstrate that incorporating the gel-forming polymer ethyl cellulose to ethanol localizes distribution. This therapy may have low barrier of entry cancer care low- middle- income countries. Materials Methods relationship radiodensity concentration was...
Abstract In low-resource settings, surgery or radiation are inaccessible to 90% of cancer patients due inadequate infrastructure and lack trained personnel. Resource appropriate technologies must be developed make treatments accessible. Ablative techniques, such as radiofrequency ablation often used a minimally invasive alternative surgery. However, energy-based techniques require expensive machinery steady supply electricity consumables. To address these shortcomings, we have low-cost...
Acoustic tweezing rheometry is an innovative technology for low-volume non-contact rheological analysis of complex fluids characterized by increased sensitivity and accuracy as compared to traditional contact techniques. In this method, a small drop fluid sample levitated in air acoustic radiation forces its viscoelasticity at different time instants measured from shape changes. The rheometer operates two modes: quasi-static oscillatory. This presentation focuses on the oscillatory technique...
Use of genomic assays to determine distant recurrence risk in patients with early stage breast cancer has expanded and is now included the American Joint Committee on Cancer staging manual. Algorithmic alternatives using standard clinical pathology information may provide equivalent benefit settings where tests, such as OncotypeDx, are unavailable. We developed an artificial neural network (ANN) model nonlinearly estimate recurrence. In addition pathological variables, we enhanced our...
e17507 Background: Historically, the only curative option for patients with recurrent localized cervical cancer after platinum-based chemotherapy and radiation is pelvic exenteration. For non-surgical candidates, treatment options include systemic therapy chemotherapy, bevacizumab or pembrolizumab. However, these therapies are not curative. Addition of local ablative to a promising option, as this combination can induce more robust antitumor immune response. We developed polymer-assisted...