A5072532679- Celiac Disease Research and Management
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Microscopic Colitis
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Thyroid Disorders and Treatments
- Eosinophilic Esophagitis
- SARS-CoV-2 detection and testing
- Gastrointestinal disorders and treatments
- Autoimmune Bullous Skin Diseases
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Systemic Sclerosis and Related Diseases
- Inflammatory Myopathies and Dermatomyositis
- Renal Diseases and Glomerulopathies
- T-cell and B-cell Immunology
- Thyroid Cancer Diagnosis and Treatment
- Diabetes and associated disorders
- Contact Dermatitis and Allergies
- Asthma and respiratory diseases
- Ophthalmology and Eye Disorders
- Liver Diseases and Immunity
- Erythrocyte Function and Pathophysiology
Azienda Ospedaliera Santa Maria Degli Angeli
2014-2024
Ospedale Santa Maria
2021-2024
Bipar
2023
Presidio Ospedaliero
1984-2022
Azienda Ospedaliera S.Maria
2003-2016
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2015
ABSTRACT Objectives: Positivity of both immumoglobulin A anti‐tissue transglutaminase (TTG) and anti‐endomysium antibodies (EMA) has a positive predictive value nearly 100% for celiac disease (CD). The objective the present study was to evaluate whether patients any age, with high pretest probability CD titre anti‐TTG EMA positivity, have intestinal damage may not require biopsy final diagnosis. Methods: retrospective analysis 412 consecutively referred patients, age range 10 months 72...
Assays for IgG antibodies against deamidated gliadin (IgG-anti-dGli) are comparable in performance with tests detecting IgA tissue transglutaminase (IgA-anti-tTG) diagnosing celiac disease (CD). IgA-anti-tTG absent deficiency, a condition often associated CD. In IgG-anti-tTG, which have lower overall diagnostic accuracy, routinely measured. We examined whether IgG-anti-dGli would be useful CD patients deficiency.We studied 34 IgA-deficient patients, 185 IgA-competent newly diagnosed children...
Celiac disease (CD) may be found in association with other autoimmune diseases. We investigated the relation between hepatitis (AIH) and CD by assessing prevalence of IgA IgG anti-tissue transglutaminase (tTG) antibodies AIH, verifying whether findings were associated clinical histological features CD. Forty-seven consecutive patients AIH (type I: n = 39; type II: 8) studied. One hundred chronic C, 120 healthy blood donors also studied as controls. analyzed sera for presence anti-tTG using a...
Abstract Background: Thyroid stimulating hormone (TSH) receptor autoantibodies (TRAb) are pathogenetic and diagnostic hallmarks of Graves’ disease (GD). Three varieties TRAb have been described: (S-TRAb), blocking (B-TRAb), apoptotic (A-TRAb) autoantibodies. Very recently, the first immunoassay method (Immulite TSI assay, Siemens Healthcare Diagnostics) declared to measure serum S-TRAb concentration, has made available in an automated commercial platform. The aim study was evaluate ability...
Diagnosis of coeliac disease (CD) relies on a combination clinical, genetic, serological and duodenal morphological findings. The ESPGHAN suggested that biopsy may not be necessary in all cases. New guidelines include omission if the concentration CD-specific antibodies exceeds 10 times upper limit normal (10 ULN) other criteria are met. We analysed ULN criterion investigated multiple antibody-assays. Serum was collected from 1071 children with (376 CD patients, 695 disease-controls)....
The diagnosis of bullous pemphigoid is based on clinical observations and the presence autoantibodies directed against proteins dermoepidermal junction. Human recombinant BP180 BP230 peptides have been used to develop new quantitative enzyme immunoassays (EIA) for detection specific antibodies. This study evaluated sensitivity specificity a immunoassay correlations. Serum samples were tested from patients with pemphigoid, other skin diseases, healthy donors. Autoantibodies anti-BP230...
Abstract : Clinical studies have estimated a 10‐ to 20‐fold increased risk for celiac disease (CD) in patients with selective IgA deficiency (SIgAD). For this reason, screening CD is mandatory SIgAD patients, but it represents special challenge since the specific class antibodies against gliadin (AGA), endomysium (EMA), and tissue‐transglutaminase (tTG) are not produced CD. IgG counterparts of these may be informative; particular EMA has been demonstrated valid marker diagnosing cases, used...
Reflex tests are widely used in clinical laboratories, for example, to diagnose thyroid disorders or the follow-up of prostate cancer. antinuclear antibodies (ANA) have recently gained attention as a way improve appropriateness immunological diagnosis autoimmune rheumatic diseases and avoid waste resources. However, ANA-reflex test is not simple other consolidated reflex (the TSH-reflex PSA-reflex tests) because intrinsic complexity ANA performed by indirect immunofluorescence method on...
Abstract The association between celiac disease (CD) and primary biliary cirrhosis (PBC) is well documented in medical literature; however, a high frequency of false positive results the anti‐transglutaminase (anti‐tTG) test has been reported patients with PBC. To verify if for anti‐tTG autoantibody are positives due to cross reactivity mitochondrial antigens, we studied 105 adult affected PBC, anti‐mitochondrial M2 antibodies. Anti‐tTG IgA antibodies were by using six different...