Isabel Almeida
A5079349581- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Salivary Gland Disorders and Functions
- Eosinophilic Disorders and Syndromes
- Electrochemical sensors and biosensors
- Blood disorders and treatments
- Connective Tissue Growth Factor Research
- Asthma and respiratory diseases
- Atherosclerosis and Cardiovascular Diseases
- Respiratory Support and Mechanisms
- Electrochemical Analysis and Applications
- Heart Failure Treatment and Management
- Immune Cell Function and Interaction
- Vasculitis and related conditions
- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- Diagnosis and Treatment of Venous Diseases
- Monoclonal and Polyclonal Antibodies Research
- Skin Diseases and Diabetes
Universidade Federal de Juiz de Fora
2025
Centro Hospitalar do Porto
2014-2024
University of Lisbon
2010-2024
Universidade do Porto
2011-2024
Karolinska University Hospital
2024
Karolinska Institutet
2024
Center for Rheumatology
2024
Hospital de Santo António
2001-2023
CUF Porto Hospital
2013-2018
Hospital Pulido Valente
2013
Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could classified into groups defined by molecular pattern. This study was undertaken to identify clusters for reclassifying diseases independently clinical diagnosis.Unsupervised clustering integrated whole blood transcriptome methylome cross-sectional data on 955 with 7 267 healthy controls undertaken. In addition, an inception cohort...
There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies -in part- because of the heterogeneity clinical manifestation and pathophysiology disease. Finding common molecular signatures among patient subgroups could improve our understanding etiology, facilitate development targeted therapeutics. Here, we report, cross-sectional cohort, classification scheme syndrome patients based on...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown origin, in which both genetic and environmental factors are involved. One such factor vitamin D, vital hormone that plays specific function the immune system homeostasis, acting through nuclear receptor (VDR) expressed all cells. Several polymorphisms gene encodes this have been described. Though inconsistently, these associated with clinical manifestations SLE development.The aim study was to determine possible...
Autoimmune diseases (AIDs) are characterized by a multifactorial aetiology and complex genetic background, with the MHC region playing major role. We genotyped for HLA-DRB1 locus 1228 patients AIDs-213 Systemic Lupus Erythematosus (SLE), 166 Psoriasis or Psoriatic Arthritis (Ps + PsA), 153 Rheumatoid (RA), 67 Sclerosis (SSc), 536 Multiple (MS), 93 Myasthenia Gravis (MG) 282 unrelated controls. confirmed previously established associations of HLA-DRB1(∗)15 (OR = 2.17) HLA-DRB1(∗)03 1.81)...
IntroductionCurrent therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% patients, highlighting the urgent need for additional options.MethodsWe analysed differentially expressed genes peripheral blood from active LN (n=41) and non-renal (n=62) patients versus healthy controls (n=497) European PRECISESADS project (NTC02890121), dysregulated gene modules a discovery (n=26) replication (n=15) set cases.ResultsReplicated qualified correlation analyses...
INTRODUCTION Obesity is a chronic disease associated with significant metabolic and cardiovascular complications. Bariatric surgery remains the most effective treatment for severe obesity, achieving substantial sustained weight loss while improving glycemic control reducing risk. Glucagon-like peptide-1 (GLP-1) receptor agonists have emerged as pharmacological alternative, offering reduction benefits lower risk of immediate However, differences in long-term efficacy, safety, adherence raise...
Introduction. The presence of anti-Ro52 antibodies has been reported in a wide variety autoimmune diseases, particularly myositis, scleroderma, and liver diseases. Clinical significance remains controversial, studies are lacking for clarifying the association with interstitial lung disease (ILD) connective tissue diseases (CTD). Objectives. To determine if associated ILD CTD other than scleroderma. Methods. Single-center, retrospective study based on immunoblotting panel analysis patients...
The prevalence of malnutrition in ambulatory patients with heart failure is difficult to determine, depending on the timing and methodology. To determine nutritional status outpatients systolic Mini Nutritional Assessment (MNA) full short-form versions, evaluate its relationship short-term prognosis, biomarkers quality life. Fifty consecutive (70% male), geriatric (74.3+ 6.2years old) stable outpatient (NYHA class II 68%, III 32%) left ventricular ejection fraction 26.7 +11.5% were included...
A measles outbreak has been occurring in a healthcare setting Porto, Portugal, since early March 2018, posing public health challenges for central hospital and the community. Up to 22 April, 96 cases were confirmed, 67 vaccinated workers, mostly between 18-39 years old. Following identification of first cases, control measures rapidly implemented. Concomitantly, other notified Northern Region country. No common epidemiological link was identified.
The analysis of annotated transcripts from genome-wide expression studies may help to understand the pathogenesis complex diseases, such as systemic sclerosis (SSc). We performed a whole blood (WB) transcriptome on RNA collected in context European PRECISESADS project, aiming at characterising pathways that differentiate SSc controls and are reproducible geographically diverse populations.Samples 162 patients 252 were stabilisers. Cases divided into discovery (n=79+163; Southern Europe)...
Abstract One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers leukocyte populations and further mean fluorescence intensities cell markers, especially when data are generated from different instruments. Here, we describe an innovative standardization workflow all carry out any large-scale, multicentric flow analysis whatever duration, number or type instruments required realization such projects.
Anti-Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and undifferentiated connective tissue disease (UCTD). This study was undertaken to determine if there is a common signature for all patients expressing anti-Ro 60 regardless of their phenotype.