Mariana Brandão
A5038957143- Systemic Lupus Erythematosus Research
- Salivary Gland Disorders and Functions
- Immunodeficiency and Autoimmune Disorders
- Mycobacterium research and diagnosis
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Atherosclerosis and Cardiovascular Diseases
- Systemic Sclerosis and Related Diseases
- Healthcare during COVID-19 Pandemic
- Infectious Diseases and Tuberculosis
- Otitis Media and Relapsing Polychondritis
- Rheumatoid Arthritis Research and Therapies
- Cervical Cancer and HPV Research
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- Hepatitis C virus research
- Blood disorders and treatments
- Renal Diseases and Glomerulopathies
- Ocular Diseases and Behçet’s Syndrome
- Cardiovascular Function and Risk Factors
- Sepsis Diagnosis and Treatment
- Vasculitis and related conditions
- Hemoglobinopathies and Related Disorders
- Tuberculosis Research and Epidemiology
- Lymphoma Diagnosis and Treatment
Centro Hospitalar de Vila Nova de Gaia
2023-2025
Institute of Biomedical Science
2021-2024
Universidade do Porto
2015-2024
Centro Hospitalar do Porto
2012-2024
Karolinska University Hospital
2024
Center for Rheumatology
2024
Karolinska Institutet
2024
Administração Regional de Saúde de Lisboa e Vale do Tejo
2024
Hospital de Santo António
2000-2023
Azienda Ospedaliero-Universitaria Careggi
2023
Clinical heterogeneity, a hallmark of systemic autoimmune diseases, impedes early diagnosis and effective treatment, issues that may be addressed if patients could classified into groups defined by molecular pattern. This study was undertaken to identify clusters for reclassifying diseases independently clinical diagnosis.Unsupervised clustering integrated whole blood transcriptome methylome cross-sectional data on 955 with 7 267 healthy controls undertaken. In addition, an inception cohort...
There is currently no approved treatment for primary Sjögren's syndrome, a disease that primarily affects adult women. The difficulty in developing effective therapies -in part- because of the heterogeneity clinical manifestation and pathophysiology disease. Finding common molecular signatures among patient subgroups could improve our understanding etiology, facilitate development targeted therapeutics. Here, we report, cross-sectional cohort, classification scheme syndrome patients based on...
IntroductionCurrent therapeutic management of lupus nephritis (LN) fails to induce long-term remission in over 50% patients, highlighting the urgent need for additional options.MethodsWe analysed differentially expressed genes peripheral blood from active LN (n=41) and non-renal (n=62) patients versus healthy controls (n=497) European PRECISESADS project (NTC02890121), dysregulated gene modules a discovery (n=26) replication (n=15) set cases.ResultsReplicated qualified correlation analyses...
Introdução: O Transtorno de Ansiedade Generalizada (TAG) é uma condição psiquiátrica caracterizada por preocupações excessivas e persistentes, impactando a qualidade vida dos indivíduos. A complexidade sintomas associados ao TAG demanda um manejo eficaz, especialmente meio intervenções farmacológicas. Objetivo: Este estudo visa analisar os efeitos colaterais tratamentos farmacológicos do TAG, proporcionando compreensão impactos adversos essas terapias. Metodologia: Realizou-se revisão...
O avanço da tecnologia mecanizada principalmente a indústria automobilística, trouxe consigo uma mudança na cinemática, resultando em traumas complexos e de alta energia. manejo das fraturas com perda substância exposição ósseo-tendíneas, são lesões ainda desafiadoras grande interesse ortopedia traumatologia moderna. Ainda que existam várias opções técnicas terapêuticas, é necessário avaliar perfil do paciente, características lesão, indicações, experiência cirurgião, disponibilidade insumos...
ANCA-associated vasculitis (AAV) can affect all age groups. We aimed to show that differences in disease presentation and 6 month outcome between younger- older-onset patients are still incompletely understood.
Abstract One of the most challenging objective for clinical cytometry in prospective multicenter immunomonitoring trials is to compare frequencies, absolute numbers leukocyte populations and further mean fluorescence intensities cell markers, especially when data are generated from different instruments. Here, we describe an innovative standardization workflow all carry out any large-scale, multicentric flow analysis whatever duration, number or type instruments required realization such projects.
Anti-Ro autoantibodies are among the most frequently detected extractable nuclear antigen autoantibodies, mainly associated with primary Sjögren's syndrome (SS), systemic lupus erythematosus (SLE), and undifferentiated connective tissue disease (UCTD). This study was undertaken to determine if there is a common signature for all patients expressing anti-Ro 60 regardless of their phenotype.
Abstract Primary Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lymphocytic infiltration and damage of exocrine salivary lacrimal glands. The etiology SS complex with environmental triggers genetic factors involved. By conducting an integrated multi-omics study, we confirmed vast coordinated hypomethylation overexpression effects in IFN-related genes, what known as the IFN signature. Stratified conditional analyses suggest strong interaction between SS-associated...
BACKGROUND Preoperative anaemia is associated with poor postoperative outcomes; however, few studies have reported its prevalence in developing countries and association significant outcomes. OBJECTIVE We aimed to identify the of outcomes a major public hospital Brazil. DESIGN Retrospective cohort study. SETTING Single-centre, 860-bed, quaternary university-affiliated teaching Southern PATIENTS included adult patients who had undergone surgery between 2015 2019. Main outcome measures: The...
Abstract IgM antibodies against phosphorylcholine (anti-PC) and malondialdehyde (anti-MDA) may have protective properties in cardiovascular rheumatic diseases. We here compare these systemic conditions study their properties. Anti-PC anti-MDA was measured using ELISA patients with SLE (374), RA (354), Mixed connective tissue disease (MCTD, 77), Systemic sclerosis (SSc, 331), Sjögren’s syndrome (SjS, 324), primary antiphospholipid (PAPs, 65), undifferentiated (UCTD, 118) 515 matched healthy...
Abstract Aim Patients with rheumatoid arthritis (RA) have an increased risk of cardiac dysfunction and heart failure (HF) due to a pro-inflammatory state. Detecting in RA is challenging as these patients often present preserved ejection fraction (EF) but may subclinical ventricular dysfunction. Echocardiographic strain analysis promising tool for early detection left systolic (LVSD). This study assesses the prognostic role RA. Methods results Prospective 277 without known disease EF,...
<h3>Objective</h3> To describe the experience of anifrolumab in Systemic Lupus Erythematosus (SLE) patients that entered Early Access Program (EAP) between 2022 and 2023 a Portuguese Single Center Cohort. <h3>Methods</h3> Patients who were treated with on EAP included. Retrospective patients' clinical charts review to demographic data, manifestations, serological characteristics, previous infections treatments, response anifrolumab, time reasons stop treatment adverse events....
Abstract The heterogeneity of systemic lupus erythematosus (SLE) can be explained by epigenetic alterations that disrupt transcriptional programs mediating environmental and genetic risk. This study evaluated the contribution to SLE considering molecular serological subtypes, genetics status, followed drug target discovery. We performed a stratified epigenome-wide association studies whole blood DNA methylation from 213 patients 221 controls. Methylation quantitative trait loci analyses,...
Abstract Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A , C4B and HERV-K were analyzed 26,633 individuals validated an independent cohort. Our results showed that higher confers protection to SSc, deviations from parity augmented The contributed per copy differed by sex. Stronger was afforded men women. correlated well its...
Patients with rheumatoid arthritis (RA) have different presentations and prognoses. Cluster analysis based on proteomic signatures creates independent phenogroups of patients pathophysiological backgrounds. We aimed to identify distinct clusters RA circulating biomarkers.This was a cohort study including 399 patients. Clustering performed 94 proteins (92 CVDII Olink®, high-sensitivity troponin T, C-reactive protein). Unsupervised clustering using partitioning cluster algorithm.The algorithm...