Sergio Aguilar-Fernández
A5081241929- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Atherosclerosis and Cardiovascular Diseases
- Cancer Immunotherapy and Biomarkers
Centro Nacional de Análisis Genómico
2023-2024
Centre for Genomic Regulation
2021-2022
The tumor immune microenvironment is a main contributor to cancer progression and promising therapeutic target for oncology. However, microenvironments vary profoundly between patients, biomarkers prognosis treatment response lack precision. A comprehensive compendium of cells required pinpoint predictive cellular states their spatial localization. We generated single-cell atlas, jointly analyzing published data sets >500,000 from 217 patients 13 types, providing the basis patient...
Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of immunological defense against inhaled or ingested pathogens. We generated an atlas human tonsil composed >556,000 cells profiled across five different data modalities, including single-cell transcriptome, epigenome, proteome, and immune repertoire sequencing, as well spatial transcriptomics. This census identified 121 cell types states, defined developmental trajectories, enabled understanding functional...
Abstract Palatine tonsils are secondary lymphoid organs representing the first line of immunological defense against inhaled or ingested pathogens. Here, we present a comprehensive census cell types forming human tonsil by applying single-cell transcriptome, epigenome, proteome and adaptive immune repertoire sequencing as well spatial transcriptomics, resulting in an atlas >357,000 cells. We provide glossary 121 annotated states, disentangle gene regulatory mechanisms that drive cells...
Abstract Despite the wealth of publicly available single-cell datasets, our understanding distinct resident immune cells and their unique features in diverse human organs remains limited. To address this, we compiled a meta-analysis dataset 114,275 CD45 + sourced from 14 healthy donors. While transcriptome relatively consistent across organs, analysis has unveiled organ-specific gene expression differences ( GTPX3 kidney, DNTT ACVR2B thymus). These alterations are linked to different...
Abstract Inflammation is a biological phenomenon involved in wide variety of physiological and pathological processes. Although controlled inflammatory response beneficial for restoring homeostasis, it can become unfavorable if dysregulated. In recent years, major progress has been made characterizing acute chronic inflammation specific diseases. However, global, holistic understanding still elusive. This particularly intriguing, considering the crucial function human health its potential...