A5101569386- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Glycosylation and Glycoproteins Research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- vaccines and immunoinformatics approaches
- Advanced Biosensing Techniques and Applications
- Viral gastroenteritis research and epidemiology
- T-cell and B-cell Immunology
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Ocular Oncology and Treatments
- Cancer and Skin Lesions
- Lymphoma Diagnosis and Treatment
- Parasitic Infections and Diagnostics
- Engineering Technology and Methodologies
- Acute Myeloid Leukemia Research
- Nonmelanoma Skin Cancer Studies
- Viral Infectious Diseases and Gene Expression in Insects
- Cutaneous lymphoproliferative disorders research
- Immune cells in cancer
- Microfluidic and Capillary Electrophoresis Applications
- Immunodeficiency and Autoimmune Disorders
- Dental Implant Techniques and Outcomes
Immatics Biotechnologies (Germany)
2018-2023
University of Bern
2022
University of Tübingen
2011-2018
University Medical Center Freiburg
2017
Synimmune (Germany)
2015-2016
FZI Research Center for Information Technology
1997
Upon antigen contact, epidermal Langerhans cells (LC) and dendritic (DC) leave peripheral organs home to lymph nodes via the afferent lymphatic vessels then assemble in paracortical T cell zone present lymphocytes. Since splice variants of CD44 promote metastasis certain tumors nodes, we explored expression proteins on migrating LC DC. We show that upon DC upregulate pan epitopes encoded by variant exons v4, v5, v6, v9. Antibodies against inhibit emigration from epidermis, prevent binding...
T cell receptor (TCR)-based immunotherapy has emerged as a promising therapeutic approach for the treatment of patients with solid cancers. Identifying peptide-human leukocyte antigen (pHLA) complexes highly presented on tumors and rarely expressed healthy tissue in combination high-affinity TCRs that when introduced into cells can redirect to eliminate tumor but not is key requirement safe efficacious TCR-based therapies. To discover shared antigens could be targeted via adoptive therapy,...
FLT3 is a receptor-tyrosine-kinase that expressed on leukemic cells of the myeloid and lymphoid lineage rather specifically. We here report construction selection bispecific X CD3 antibodies in new recombinant format, termed Fabsc, resembles normal antibody structure more closely than well-established single chain (bssc)-format. Our preferred antibody, which emerged from an initial procedure utilizing different FLT3- CD3-antibodies, contains FLT3-antibody 4G8 CD3-antibody UCHT1. The UCHT1...
The TNF receptor family member OX40 promotes activation and proliferation of T cells, which fuels efforts to modulate this immune checkpoint reinforce antitumor immunity. Besides NK cells are a second cytotoxic lymphocyte subset that contributes immunity, particularly in leukemia. Accordingly, these being clinically evaluated for cancer treatment through multiple approaches, such as adoptive transfer ex vivo expanded polyclonal (pNKC). Here, we analyzed whether how its ligand (OX40L)...
Functionally empty and peptide-receptive soluble HLA-A*02:01 enables high-throughput analysis of TCR binding to peptide-MHCs. See the related Research Article by Saini et al . in this issue.
Prognosis of primary refractory and relapsed pediatric B-lineage acute lymphoblastic leukemia (ALL) is very poor. Relapse rates significantly correlate with persistent minimal residual disease (MRD). In MRD, favorable effector-target ratios prevail thus this situation might be optimally suited for immunotherapy antibodies recruiting immunological effector cells. We here report on the generation, preclinical characterization first clinical application in ALL an Fc-optimized CD19 antibody....
Bispecific T cell receptor (TCR)-based molecules capable of redirecting and activating cells towards tumor represent a novel promising class biotherapeutics for the treatment cancer. Usage TCRs allows targeting intracellularly expressed highly selective cancer antigens, but also requires complex maturation process to increase naturally low affinity stability TCRs. Even though TCR domains can be matured via phage yeast display, these techniques share disadvantages non-human glycosylation...
OX40 and its ligand are members of the TNF/TNF receptor superfamily, which includes various molecules influencing cellular signaling function both tumor immune cells. The ability to promote proliferation differentiation activated T cells fueled present attempts modulate this checkpoint reinforce antitumor immunity. While we recently found evidence for involvement in pathophysiology acute myeloid leukemia including natural killer (NK) cell immunosurveillance, less is known on role...
Peptide human leukocyte antigen (pHLA) targeting therapeutics like T-cell receptor based adoptive cell therapy or bispecific T engaging molecules hold great promise for the treatment of cancer. Comprehensive pre-clinical screening therapeutic candidates is important to ensure patient safety but challenging because size potential off-target space. By combining stabilized peptide-receptive HLA with microarray printing and screening, we have developed an ultra-high-throughput platform named...
Abstract T-cell receptor (TCR)-based immunotherapy has emerged as a promising treatment modality for malignant diseases. TCRs naturally recognize human leucocyte antigen (HLA)-bound peptides from foreign and endogenous antigens regardless of their source proteins' extracellular or intracellular location. Using its proprietary discovery engine XPRESIDENT®, Immatics can identify, quantify, validate Tumor-Associated Peptides (TUMAPs) exclusively presented in cancer tissues. established...
Caries and periodontitis affect the majority of adults during their lifetime. Piezoelectric ultrasonic scalers offer great benefits prevention treatment periodontal diseases. Our group developed a novel scaler based on planar piezoelectric transducer. However, similar to other configurations, transducer's characteristics are strongly influenced by operation conditions. In this study, we investigated influence driving voltage amplitude loading force applied using physical calculus models...
Abstract B-precursor acute lymphoblastic leukemia (BCP-ALL) is the most common childhood cancer. Although this disease can be successfully treated in 80 % of patients by chemotherapy, prognosis for primary refractory or relapsed very poor. Even after allogeneic stem cell transplantation (SCT), relapse rates are considerable and correlate significantly with persistent minimal residual (MRD) prior to SCT. In an MRD constellation favorable effector-target ratios prevail thus it well suited...
Abstract Peptide-HLA (pHLA) targeting therapeutics like TCR-based adoptive cell therapy or bispecific T engaging receptor molecules hold great promise for the treatment of cancer. Comprehensive pre-clinical screening therapeutic candidates is important to ensure patient safety but challenging because size potential off-target space. By combining stabilized peptide-receptive HLA with microarray printing and screening, we have developed an ultra-high-throughput platform named ValidaTe that...
Virus-spezifische CD8 T-Zellantworten bei der chronischen HBV-Infektion sind durch bisherige experimentelle Methoden nur in einer Minderheit Patienten nachweisbar. Detektierbare HBV-spezifische T-Zellen den progressiven Verlust von Effektorfunktionen, wie Proliferation und Zytokinproduktion sowie die erhöhte Expression inhibitorischen Rezeptoren charakterisiert. Dieses Phänomen wird als T-Zell-Erschöpfung bezeichnet.