A5025077874- Molecular Junctions and Nanostructures
- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Quantum and electron transport phenomena
- X-ray Diffraction in Crystallography
- Advanced biosensing and bioanalysis techniques
- Mesoporous Materials and Catalysis
- Organic Electronics and Photovoltaics
- Machine Learning in Materials Science
- RNA Interference and Gene Delivery
- Nanowire Synthesis and Applications
- Force Microscopy Techniques and Applications
- Spectroscopy and Quantum Chemical Studies
- Electronic and Structural Properties of Oxides
- Perovskite Materials and Applications
- Graphene research and applications
- Porphyrin and Phthalocyanine Chemistry
- Dendrimers and Hyperbranched Polymers
- Immunotherapy and Immune Responses
- Innovative Microfluidic and Catalytic Techniques Innovation
- Advanced Drug Delivery Systems
- Advanced ceramic materials synthesis
- Surface and Thin Film Phenomena
- Microfluidic and Capillary Electrophoresis Applications
- Electrohydrodynamics and Fluid Dynamics
Xiamen University
2018-2025
Collaborative Innovation Center of Chemistry for Energy Materials
2018-2024
Institute of Art
2022
University of Regensburg
2022
Xiamen University of Technology
2020-2021
Deakin University
2014-2018
Huazhong University of Science and Technology
2011
Understanding the molecular basis of drug resistance and utilising this information to overcome chemoresistance remains a key challenge in oncology.Here we report that survivin, protein implicated resistance, is overexpressed cancer stem cell pool doxorubicin-resistant breast cells.Moreover, by an active targeting system consisting RNA aptamer targeted against epithelial adhesion molecule Dicer substrate survivin siRNA, could deliver high dose siRNA cells xenograft tumours.Importantly,...
The incorporation of a high percentage targeting molecules into drug delivery system is one the important methods for improving efficacy therapeutic drugs to cancer cells. PLGA-based carriers with folic acid (FA) as molecule have low efficiency due FA conjugation ratio. In this work, we fabricated FA-conjugated PLGA using crosslinker 1, 3-diaminopropane and achieved ratio 46.7% (mol/mol). as-prepared biomaterial was used encapsulate 5-fluorouracil (5-FU) nanoparticles. in vitro experiments,...
Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU cell line SW480 was obtained with up-regulation dihydropyrimidine dehydrogenase (DPYD) gene expression which convert to its inactive metabolite. To overcome ADR cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted epidermal growth factor (EGF) were used as nanocarriers deliver resistance. The...
Abstract Photoresponsive molecular systems are essential for optoelectronic devices, but most building blocks non‐photoresponsive. Employed here is a photoinduced proton transfer (PIPT) strategy to control charge transport through single‐molecule azulene junctions with visible light under ambient conditions, which leads reversible and controllable photoresponsive device based on non‐photoresponsive molecules photoacid. Also demonstrated the application of PIPT in two AND gate OR devices...
Molecular components are vital to introduce and manipulate quantum interference (QI) in charge transport through molecular electronic devices. Up now, the functional units that show QI mostly found conventional π- σ-bond-based systems; it is thus intriguing study multicenter bonding systems without both σ-conjugations. Now presence of multicenter-bond-based demonstrated for first time, single-molecule conductance investigation carborane junctions. We find all three connectivities frameworks...
Hollow mesoporous silica nanoparticles were successfully fabricated and functionalized with appropriate silanes. After modifications, amine, carboxyl, cyano, methyl groups grafted onto the all hollow maintained a spherical structure mean diameter of ~120 nm shell thickness ~10 nm. The loading capacity nanoaprticles to anticancer drug, 5‐fluorouracil, can be controlled via precise functionalization. presence amine on surface resulted in highest 28.89%, due having similar hydrophilicity but...
The manipulation of molecule-electrode interaction is essential for the fabrication molecular devices and determines connectivity from electrodes to components. Although could be controlled by design place anchor groups in different positions molecule backbones, reversible switching such connectivities remains challenging. Here, we develop an electric-field-induced strategy switch single-molecule junctions reversibly, leading same backbone. Our results offer a new concept provide feasible...
Although most molecular electronic devices and materials consist of a backbone with planar structure, twisted wires reduced inter-ring π-orbital overlap offer unique opportunity for the modularized fabrication devices. Herein we investigate tuning charge transport through localized molecules by designing highly investigating their single-molecule using scanning tunneling microscopy break junction technique. We find that anthracenediyl-core molecule 90° twist angle shows an unexpectedly high...
Inspired by the initial proposal of σ-bridged donor–acceptor (D-σ-A) single-molecule diodes in 1974, extensive studies over past 50 years have explored various designs for π-conjugated D-π–A due to their feasible chemical synthesis and effective charge transfer. However, rectification ratio has been long-term limited challenge asymmetric electronic coupling induce effect. Here, we present a supramolecular diode constructed through an intramolecular π–π interaction-driven assembly strategy....
A back-gated chip to modulate charge transport through single-molecule junctions.
Seebeck coefficient measurements provide unique insights into the electronic structure of single-molecule junctions.
The S N 2 reaction, typically enhanced by polar solvents, can be accelerated using external electric fields within nanogaps in non-polar solvents.
The van der Waals interactions (vdW) between π-conjugated molecules offer new opportunities for fabricating heterojunction-based devices and investigating charge transport in heterojunctions with atomic thickness. In this work, we fabricate sandwiched single-molecule bilayer-graphene junctions via vdW characterize their electrical properties by employing the cross-plane break junction (XPBJ) technique. experimental results show that through is determined size layer number of molecular...
Open AccessCCS ChemistryRESEARCH ARTICLES22 Oct 2022Structure Identification for Force-Induced Reaction Using Single-Molecule Conductance Measurement Jueting Zheng†, Wenli Gao†, Taige Lu, Lijue Chen, Luchun Lin, Ruiyun Huang, Yongxiang Tang, Gang Dong, Junyang Liu, Yifei Pan, Wengui Weng and Wenjing Hong Zheng† State Key Laboratory of Physical Chemistry Solid Surfaces, College Chemical Engineering Institute Artificial Intelligence Innovation Sciences Technologies Energy Materials Fujian...
Abstract Photoresponsive molecular systems are essential for optoelectronic devices, but most building blocks non‐photoresponsive. Employed here is a photoinduced proton transfer (PIPT) strategy to control charge transport through single‐molecule azulene junctions with visible light under ambient conditions, which leads reversible and controllable photoresponsive device based on non‐photoresponsive molecules photoacid. Also demonstrated the application of PIPT in two AND gate OR devices...
Quantum interference offers a unique opportunity to tune the charge transport through molecular devices and materials at phase-coherent scale. Herein, we propose direct way suppress between two transmission paths in meta-connected benzene ring by blocking particular path using Jahn-Teller distortion. By modification of hydroxyls introduce intramolecular hydrogen bonds, conductance single-molecule junctions with is enhanced ∼45 times transition from through-bond through-space was observed...
Abstract Molecular components are vital to introduce and manipulate quantum interference (QI) in charge transport through molecular electronic devices. Up now, the functional units that show QI mostly found conventional π‐ σ‐bond‐based systems; it is thus intriguing study multicenter bonding systems without both σ‐conjugations. Now presence of multicenter‐bond‐based demonstrated for first time, single‐molecule conductance investigation carborane junctions. We find all three connectivities...
ToF-SIMS was successfully applied to characterize and quantify the EGF grafted on hollow mesoporous silica nanoparticles.