A5039148398- Bone health and osteoporosis research
- RNA Interference and Gene Delivery
- Plant pathogens and resistance mechanisms
- Soybean genetics and cultivation
- Powdery Mildew Fungal Diseases
- Viral Infections and Vectors
- HIV Research and Treatment
- Sunflower and Safflower Cultivation
- Virus-based gene therapy research
- Mosquito-borne diseases and control
- Bacteriophages and microbial interactions
- Virology and Viral Diseases
- Hip and Femur Fractures
- COVID-19 epidemiological studies
- Plant responses to water stress
- SARS-CoV-2 and COVID-19 Research
- Plant Pathogens and Resistance
- Genetic and Environmental Crop Studies
- Animal Disease Management and Epidemiology
- Livestock Management and Performance Improvement
- Genetics and Plant Breeding
- Plant-Derived Bioactive Compounds
- Agricultural Economics and Practices
- Seed and Plant Biochemistry
- Viral gastroenteritis research and epidemiology
Agharkar Research Institute
2025
United Arab Emirates University
2021-2024
Ganga Hospital
2021-2024
Government Mohan Kumaramangalam Medical College
2022
Government Medical College
2022
Manipal Academy of Higher Education
2015-2020
Guru Nanak Institutions
2018
University of Agricultural Sciences Raichur
2017
PSG Institute of Medical Sciences & Research
2015
Institute of Medical Sciences
2015
Nipah Virus (NiV) is a highly fatal emerging zoonotic virus and potential threat to global health security. Here we describe the characteristics of NiV outbreak that occurred in Kerala, India, during May–June 2018. We used real-time reverse transcription polymerase chain reaction analysis throat swab, blood, urine, cerebrospinal fluid specimens detect NiV. Further, viral genome was sequenced subjected phylogenetic analysis. conducted an epidemiologic investigation elucidate dynamics...
Global warming-induced abiotic stresses, such as waterlogging, significantly threaten crop yields. Increased rainfall intensity in recent years has exacerbated waterlogging severity, especially lowlands and heavy soils. Its is projected to increase by 14–35% the future, posing a serious risk production achievement of sustainable development goals. Soybean, major global commercial cultivated across diverse climates, highly sensitive with yield losses up 83% due impaired root morphology...
<title>Abstract</title> Soybean domestication has been essential for crop evolution, adaptation, and modern breeding. Despite advancements in understanding soybean genetics, the genetic basis of DRTs yet to be fully explored, particularly context genome-wide association studies (GWASs) gene interaction analyses (epistasis). This study evaluated 198 diverse accessions using 23,574 high-quality SNPs obtained via ddRAD-seq. Nine key DRTs—including those related seed size (length, width,...
Nipah virus (NiV) is 1 of 10 potential causes imminent public health emergencies international concern. We investigated the NiV outbreak that occurred in May 2018 Kerala, India. Here we describe longitudinal characteristics cell-mediated and humoral immune responses to infection during acute convalescent phases 2 human survivors.Serial blood samples were obtained from only survivors Kerala. used flow cytometry determine absolute T-lymphocyte B-lymphocyte counts phenotypes both T B cells....
Cervical cancer is the second commonest among Indian women and its association with human papilloma virus (HPV) well established. This preventable accounts for maximum number of related deaths rural women. Unlike in developed countries there are no organized cervical screening programmes India due to lack resources manpower.To detect genital HPV infection using urine samples asymptomatic age group 18-65 years.The study area chosen was Perdoor village Udupi Taluk, Karnataka State all years...
Kyasanur Forest disease (KFD) is a tick-borne, acute, febrile viral illness endemic in southern India. No major studies have been done to understand the adaptive immune response during KFDV infection humans. In this study, KFDV-positive patients were prospectively enrolled, and repeated peripheral blood collections performed. Clinical virologic characterization of these samples reported along with phenotypic analysis cellular immunity quantitation humoral immunity. We noted robust T B cell...
Increasing seed yield and oil content is one of the most important goals in sunflower (Helianthus annuus L.) breeding programs. The aim any plant breeder includes selection from natural population or artificially developed for several characters. In present investigation, twenty hybrids were evaluated various parameters under field conditions to estimate genetic parameters, correlation coefficient path analysis. Analysis variance mean performance its components revealed significant...
The retroviral Gag precursor plays a central role in the selection and packaging of viral genomic RNA (gRNA) by binding to virus-specific signal(s) (psi or ψ). Previously, we mapped feline immunodeficiency virus (FIV) ψ two discontinuous regions within 5′ end gRNA that assumes higher order structure harboring several structural motifs. To better define region elements important for packaging, methodically investigated these FIV sequences using genetic, biochemical, structure–function...
Using molecular markers one can examine genetic diversity of species, cultivars, lines and forms sunflower, identify genotypes, systematize collection material, classify heterosis groups construct maps. Fourteen parental genotypes sunflower viz.,CMS-2A, CMS-821A, CMS-850A, R-10-46-2A, CMS-A4, CMS-A6, CMS-A10, R-GM-39, R-GM-41, R-GM-49, R-GM-69, 83-Br, R-393 R2F01120B were analyzed for using 15 RAPD 44 SSR primers. The similarity index computed considering pooled data showed very wide range...
Acute viral respiratory infections (AVRI) are a leading cause of morbidity and mortality among all age groups globally. Except for Influenza virus Respiratory Syncytial virus, mostly aetiology AVRI remains undiagnosed. Lately, human coronaviruses (HCoVs) have emerged as an important AVRI. A laboratory based retrospective cross sectional study was conducted in which samples (throat swabs) patients (n = 864), with negative SARI, between Jan 2011-Dec 2012 were tested HCoVs including MERS-CoV...
Simian immunodeficiency virus (SIV) is an important lentivirus used as a non-human primate model to study HIV replication, and pathogenesis of human AIDS, well potential vector for gene therapy. This investigated the role single-stranded purines (ssPurines) genomic RNA (gRNA) packaging determinants in SIV replication. Similar ssPurines have been implicated motifs gRNA many retroviruses like, HIV-1, MPMV, MMTV by serving Gag binding sites during virion assembly. In examining secondary...
The simian immunodeficiency virus (SIV) precursor polypeptide Pr55Gag drives viral assembly and facilitates specific recognition packaging of the SIV genomic RNA (gRNA) into particles. While several studies have tried to elucidate role by expressing its different components independently, using full-length not been conducted, primarily due unavailability purified biologically active Pr55Gag. We successfully expressed soluble, with His6-tag in bacteria it affinity gel filtration...
Background Infections due to drug-resistant herpes simplex viruses (HSV) represent an important clinical concern, especially in immunocompromised patients. The present study was aimed at detecting acyclovir (ACV) susceptibility HSV samples. Methods A total of 13 HSV-positive samples (5 HSV-1 and 8 HSV-2) recovered from patients (1 12 unknown immune status) were included the study. genotypic analysis involved initial UL23 (thymidine kinase) gene sequencing, followed by a confirmatory...
Powdery mildew caused by Golovinomyces cichoracearum is the most important disease on sunflower worldwide. The investigation was undertaken to determine mode of genetic inheritance powdery resistance in five F1 and F2 populations sunflower. four hybrids were derived crossing resistant with susceptible genotype one hybrid between highly genotype. Out 23 hybrids, crosses viz., PM-22x PM-36, PM-14xPM-36, PM-16xPM-38, PM-17xPM-35 PM-34x PM-23 under natural as well artificial epiphytotic...
Influenza viruses are major respiratory pathogens that cause seasonal epidemics and occasional pandemics. Immune response to influenza is majorly targeted against the hemagglutinin antigen. A laboratory-based retrospective cross-sectional study was conducted on 50 acute follow-up samples assess immune A(H1N1)pdm09 virus after natural infection detect presence of pre-existing antibodies A(H3N2) B viruses. Two-fourfold rise in hemagglutination-inhibition (HAI) titer observed 100% for virus. No...
The aim of this study is to investigate the possible risk factors poor sleep quality among patients with type 2 diabetes mellitus on insulin therapy. considered were age, sex, body mass index (BMI), glycosylated haemoglobin (HbA1c), duration and depression. A total 202 diabetic aged 20 years or older included in study. results showed that female sex depression independent for diabetics Findings may contribute disorder control which has been linked glycemic control.
The packaging of genomic RNA (gRNA) into retroviral particles relies on the specific recognition by Gag precursor signals (Psi), which maintain a complex secondary structure through long-range interactions (LRIs). However, it remains unclear whether binding to Psi alone is enough promote and what role LRIs play in this process. Using mouse mammary tumor virus (MMTV), we investigated effects mutations 4 proposed gRNA function. Our findings revealed presence an unsuspected extended LRI, hSHAPE...