A5057247505- Cholesterol and Lipid Metabolism
- Fatty Acid Research and Health
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Edible Oils Quality and Analysis
- Liver Disease Diagnosis and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Botanical Research and Chemistry
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Chromatography in Natural Products
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Lipoproteins and Cardiovascular Health
- Lipid metabolism and disorders
- Intracranial Aneurysms: Treatment and Complications
- Nutritional Studies and Diet
- Antioxidant Activity and Oxidative Stress
- Heart Failure Treatment and Management
- Pulmonary Hypertension Research and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myocardial Infarction Research
- Pharmacological Effects and Assays
Sound Shore Medical Center
2025
Albert Einstein College of Medicine
2025
Lenox Hill Hospital
2024
Northwell Health
2024
Universidad de Sevilla
2017-2023
Instituto de Biomedicina de Sevilla
2020-2023
Hospital Universitario Virgen del Rocío
2020-2023
Instituto de la Grasa
2010-2022
Consejo Superior de Investigaciones Científicas
2010-2022
Centro Andaluz de Biología Molecular y Medicina Regenerativa
2016-2021
The P2Y12 receptor antagonist ticagrelor has been shown to be clinically superior clopidogrel. Although the underlying mechanisms remain elusive, may exert off-target effects through adenosine-related mechanisms. We aimed investigate whether reduces myocardial injury a greater extent than clopidogrel after infarction (MI) at similar level of platelet inhibition and determine mechanisms.Pigs received following before MI induction: (1) placebo-control; (2) loading dose (600 mg); (3) (180 or...
The aim of this study was to determine whether isorhamnetin, an immediate 3′-O-methylated metabolite quercetin, affects proliferation, cell death, and the cycle human colon carcinoma (HCT-116) cells. Isorhamnetin found be a potent antiproliferative agent in dose- time-dependent manner, with IC50 72 μM after 48 h incubation as estimated by MTT assay. Flow cytometry fluorescence microscopy analysis showed that isorhamnetin exerted stimulatory effect on apoptosis necrosis. also increased number...
Scope We evaluated the protective effect of extra virgin olive oil (EVOO) in high‐fat diets (HFDs) on inflammatory response and liver damage a nonalcoholic fatty disease (NAFLD) mouse model. Methods results C57BL/6J mice were fed standard diet or lard‐based HFD (HFD‐L) for 12 wk to develop NAFLD. HFD‐fed then divided into four groups 24 with following: HFD‐L, HFD‐EVOO, based phenolics‐rich EVOO, reversion (standard diet). HFD‐L‐induced metabolic disorders alleviated by replacement lard EVOO....
Myocardial infarction (MI), heart failure (HF) exacerbation, and atrial fibrillation/atrial flutter (AF) affect millions of patients every year, thrombocytopenia is a common laboratory finding in hospitalized patients. This study aimed to investigate the impact admitted due MI, HF, or AF terms mortality, length stay, resource utilization, need for intubation. Methods: National Inpatient Sample Database analysis from 2016-2020. Patients with primary diagnosis AF, without secondary...
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) mediates inflammatory and potentially proatherogenic effects, whereas the role of intracellular NAMPT (iNAMPT), rate limiting enzyme in salvage pathway adenine dinucleotide (NAD)+ generation, atherogenesis is largely unknown. Here we investigated effects iNAMPT overexpression leukocytes on inflammation atherosclerosis.Low-density lipoprotein receptor-deficient mice with hematopoietic human (iNAMPThi), a western type diet, showed...
Scope The present study investigates the effect of olive oils with different phenolic content in high‐fat diets (HFDs) on hypertrophy and inflammation adipose tissue associated atherosclerosis, context obesity. Methods results Ldlr −/−.Leiden mice were fed three HFDs for 32 weeks compared standard low‐fat diet (LFD). fats provided lard (HFD‐L), extra‐virgin oil (EVOO; 79 mg kg –1 compounds, HFD‐EVOO), or EVOO rich compounds (OL, 444 HFD‐OL). All HFD‐fed became obese, but only HFD‐L–induced...
Dietary fatty acids play a role in glucose homeostasis. The aim of this study was to assess the individual relationship between dietary saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) with postprandial β-cell function insulin sensitivity subjects normal high fasting triglycerides. We assessed (by insulinogenic index ratio areas under time–concentration curve) oral minimal model indices) over four nonconsecutive, randomly assigned, high-fat meals containing panel SFA...
Abstract Dietary composition plays an important role in the pathophysiology of type 2 diabetes. Monounsaturated fatty acid consumption has been positively associated with improved insulin sensitivity and β-cell function. We examined whether extra virgin olive oil (EVOO) high fat diet (HFD) can improve glucose homeostasis. C57BL/6J mice were fed a standard or lard-based HFD to induce Then, three different based (lard, EVOO rich phenolic compounds) for 24 weeks. HFD-EVOO diets significantly...
Abstract Dietary fatty acids play a role in the pathogenesis of obesity-associated non-alcoholic liver disease (NAFLD), which is associated with insulin resistance (IR). Fatty acid composition critical for IR and subsequent NAFLD development. Extra-virgin olive oil (EVOO) main source monounsaturated (MUFA) Mediterranean diets. This study examined whether EVOO-containing high fat diets may prevent diet-induced using Ldlr−/−. Leiden mice. In female mice, effects following (HFDs) were examined:...
A lupine (<italic>Lupinus angustifolious</italic> L.) peptide prevents non-alcoholic fatty liver disease in high-fat-diet-induced obese mice.
Modifications in high-density lipoprotein (HDL) particle sizes and HDL-binding proteins have been reported stroke patients. We evaluated whether the profile, HDL composition functionality were altered patients according to their clinical outcome using modified Rankin Score at 3 months. Plasma samples obtained from treated with intravenous thrombolysis. Levels of cardiovascular inflammatory markers plasma measured Human CVD Panel 1 (Milliplex® MAP). Lipoprotein subfractions quantified by...
Scope The aim was to investigate the effect of postprandial triglyceride-rich lipoproteins (TRLs) with different fatty acid compositions on human coronary artery smooth muscle cell (hCASMC) invasion and identify molecular pathways involved. Methods results TRLs were isolated from plasma healthy volunteers after ingestion single meals enriched in MUFAs, saturated acids (SFAs), or PUFAs. hCASMC analyzed using transwell chambers Matrigel. TRLs–SFAs provoked highest invasion, followed by...
Scope Postprandial triglyceride-rich lipoproteins (TRLs) promote atherosclerosis. Recent research points the bone marrow (BM) as a primary site in We elucidated how acute administration of monounsaturated fatty acids (MUFAs) MUFAs, omega-3 polyunsaturated (PUFAs) PUFAs and saturated (SFAs) affects human circulating murine BM neutrophil lipid accumulation functionality. Methods results hypertriglyceridemia was induced healthy subjects Apoe−/− mice by dietary fats enriched PUFAs, or SFAs....