A5049115019- Cardiac Ischemia and Reperfusion
- Cell death mechanisms and regulation
- Biochemical and Molecular Research
- Carbohydrate Chemistry and Synthesis
- Nutritional Studies and Diet
- Glycogen Storage Diseases and Myoclonus
- Venous Thromboembolism Diagnosis and Management
- Thermoregulation and physiological responses
- COVID-19 Clinical Research Studies
- Congenital Heart Disease Studies
- Vitamin C and Antioxidants Research
- Cardiac Valve Diseases and Treatments
- Vitamin D Research Studies
- Sodium Intake and Health
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiac and Coronary Surgery Techniques
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Anesthesia and Neurotoxicity Research
Harvard University
2020-2021
Beth Israel Deaconess Medical Center
2018-2021
UConn Health
2018
Brown University
2010-2018
ObjectiveTo explore the possible associations of serum 25-hydroxyvitamin D [25(OH)D] concentration with coronavirus disease 2019 (COVID-19) in-hospital mortality and need for invasive mechanical ventilation.Patients MethodsA retrospective, observational, cohort study was conducted at 2 tertiary academic medical centers in Boston New York. Eligible participants were hospitalized adult patients laboratory-confirmed COVID-19 between February 1, 2020, May 15, 2020. Demographic clinical...
Specific substrate recruitment by the protein phosphatase-1 molecule G subunit holoenzyme enables maintenance of glucose levels.
Evidence is accumulating that cardiac apoptosis occurs and contributes to myocyte cell death during myocardial ischemia. Cardioplegia, defined as the temporary cessation of activity surgery, a clinically controlled condition with ischemia reperfusion. Our goal was determine whether apoptotic biomarker caspase-3 p17 elevated in coronary sinus (CS) cardioplegia if any elevations were reflected peripheral venous (PV) blood. Levels necrotic troponin I (cTnI) inflammatory marker caspase-1 p20...
Myocardial cellular necrosis occurs with acute myocardial infarction and can be identified through the measurement of serum biomarkers, such as troponin I MB isozyme creatine kinase (CK‐MB). However, both ischemia reperfusion cardiac myocytes in mouse models has been shown to result cell death via apoptosis, addition necrosis. Apoptosis during humans less, but nonetheless supporting evidence. Caspase‐3 is an end‐effecter myocyte which yields a measurable p17 fragment after activation...