A5041463302- Spondyloarthritis Studies and Treatments
- Air Quality and Health Impacts
- Psoriasis: Treatment and Pathogenesis
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Energy and Environment Impacts
- Cytomegalovirus and herpesvirus research
- Extracellular vesicles in disease
- Pediatric Hepatobiliary Diseases and Treatments
- Climate Change and Health Impacts
- Neonatal Health and Biochemistry
- Therapeutic Uses of Natural Elements
- Cancer Immunotherapy and Biomarkers
- Autoimmune and Inflammatory Disorders Research
- Rheumatoid Arthritis Research and Therapies
- Virus-based gene therapy research
- Macrophage Migration Inhibitory Factor
- Renal cell carcinoma treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cytokine Signaling Pathways and Interactions
- Inhalation and Respiratory Drug Delivery
Tehran University of Medical Sciences
2012-2024
University of Babylon
2024
University of Raparin
2024
Hawler Medical University
2024
University of Tehran
2023
Children's Medical Center
2012-2019
Center of Molecular Immunology (Cuba)
2012
Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by axial arthritis. The genetic–environmental factors seem to be involved in the pathogenesis of and debilitates patients during most productive stages their lives. aim this study was examine relationships between two environmental factors, diet air pollution with activity functional impairment AS. A case-control carried out. Thirty AS 30 age sex-matched healthy controls were included. Disease scores including BASMI,...
Chronic obstructive pulmonary disease (COPD) is characterized by progressive obstruction of airways due to chronic inflammation. Both genetic and environmental components are risk factors for COPD. The most common cause COPD smoking. However, evidence suggests that 17% 38% patients nonsmokers, so other like air pollution may also play a role.The relationship between serum exosomes exposure particulate matter (PM) <2.5 10 micrometers (µm) in the residing environment healthy groups was...
Background and aim Type 1 diabetes is an autoimmune disorder characterized by the destruction of pancreatic beta cells, leading to insulin deficiency hyperglycemia. Regulatory T cells (Tregs), particularly type regulatory (Tr1) play a crucial role in modulating responses. Therefore, this study aimed evaluate frequency Tr1 their association with aryl hydrocarbon receptor (AHR) interferon factor-4 (IRF4) gene expression levels mellitus (T1DM) compared healthy controls. Method A case-control...
The major current focus on treating rheumatoid arthritis is to put an end long-term treatments and instead, specifically block widespread immunosuppression by developing antigen-specific tolerance, while also permitting intact immune response toward other antigens occur. There have been promising preclinical findings regarding adoptive Treg cells immunotherapy with a critically responsible function in the prevention of autoimmunity, tissue repair regeneration, which make them attractive...
The considerable number of the 2019 coronavirus disease (COVID-19) patients who developed mucormycosis infections in West and Central Asia urged a need to investigate underlying causes this fatal complication. It was hypothesized that an immunocompromised state secondary excessive administration anti-inflammatory drugs responsible for outburst COVID-19 patients. Therefore, we aimed study implication two major subsets adaptive immunity T helper (Th)-1 Th17 cells development. Thirty with...
Ankylosing spondylitis (AS) is a chronic autoimmune disorder characterized by the fusion of vertebral joints and axial arthritis. The programmed death-1 (PD-1) inhibitory receptor has pivotal role in controlling T cell function may have significant impact on pathogenesis diseases such as AS pathogenesis.
Background: T-cell-mediated acute kidney transplant rejection (TCMR) is a post-transplantation complication characterized by the infiltration of immune cells into tissue and sudden dysfunction allograft. To develop effective diagnostic therapeutic methods, it crucial to understand molecular mechanisms involved in initiation progression TCMR. Janus kinase (JAK) enzymes, which are proinflammatory cytokine signal transduction, may play role Given recent development JAK inhibitors, molecules...
The International Agency for Research on Cancer (IARC) has defined outdoor air pollution and PM as the human carcinogen (Group 1), which mainly cause an increased risk of lung cancer. Scientists have considered epigenetic modifications a possible mechanism to deal with adverse effects pollution. This study aimed compare effect airborne PM10 (PM aerodynamic diameter =10?µm) in vitro global methylation peripheral blood mononuclear cells (PBMCs). was sampled metropolitan Tehran, capital Iran....
Protein tyrosine phosphatase non-receptor type 22 gene (PTPN22) single-nucleotide polymorphisms (SNP) have been associated with a number of different autoimmune diseases. This study aimed to investigate the association five PTPN22 susceptibility ulcerative colitis (UC) in Iran.A total 67 patients diagnosed UC (35 female and 32 male all under 18 years) 93 healthy subjects were selected. The samples genotyped for the, rs12760457, rs2476601, rs1310182, rs1217414, rs33996649 using real-time...