A5045586731- Antioxidant Activity and Oxidative Stress
- Diet and metabolism studies
- Drug Transport and Resistance Mechanisms
- Fatty Acid Research and Health
- Clostridium difficile and Clostridium perfringens research
- Analytical Chemistry and Chromatography
- Cholesterol and Lipid Metabolism
- Vitamin C and Antioxidants Research
- Porphyrin Metabolism and Disorders
- Cancer, Lipids, and Metabolism
- Muscle metabolism and nutrition
- Folate and B Vitamins Research
- Metabolism and Genetic Disorders
- Colorectal Cancer Screening and Detection
- Effects and risks of endocrine disrupting chemicals
- Retinoids in leukemia and cellular processes
- Gut microbiota and health
- Nutritional Studies and Diet
- Helicobacter pylori-related gastroenterology studies
- Enzyme function and inhibition
- Carcinogens and Genotoxicity Assessment
- Microscopic Colitis
- Oral and Maxillofacial Pathology
- Heme Oxygenase-1 and Carbon Monoxide
- Genetic factors in colorectal cancer
Sinai Hospital
1982-2024
Johns Hopkins University
2004-2024
NonInvasive Technologies (United States)
2003-2021
Agricultural Research Service
1989-2020
Beltsville Human Nutrition Research Center
1990-2020
Royal National Hospital for Rheumatic Diseases
2020
People’s University
2014
University of Baltimore
1998-2013
University of Maryland, Baltimore
1980-2013
Panjab University
2006-2012
Background : Most epidemiologic studies of the relationship between alcohol consumption and breast cancer risk over past decade have shown that persons who consume a moderate amount are at 40%-100% greater than those do not alcohol. Dose-response effects been observed, but no causal has established. Purpose This study examines hypothesis affects levels reproductive hormones. Methods A controlled-diet lasting for six consecutive menstrual cycles was conducted. Participants were randomly...
A study was conducted in captive baboons to determine (i) the impact of cereal dietary fibre on faecal progestogen excretion, and (ii) whether means controlling effects could be identified. Blood collected 3 days per week faeces 5 from four unanaesthetized cyclic female baboons, consecutively fed three diets 5, 10 20% for 90 diet. 2 day lag time detected before progesterone blood appeared faeces, regardless diet (mean correlation 0.62, P = 0.002). Increased had a negative effect excretion (P...
Abstract An enzyme from Clostridium perfringens capable of catalyzing the cleavage carbon-nitrogen bond in 3α,7α, 12α-trihydroxy-5β-cholan-24-oylglycine is described. The 15-fold purified hydrolyzes 3α,12α-dihydroxy-5β-cholan-24-oylglycine at a slightly faster rate than glycocholic acid. Km for acid 0.01 m acetate buffer, pH 5.6, approximately 8.0 x 10-3 m. 3,7,12-Triketo-5β-cholan-24-oylglycine, substrate analogue, and 3,7,12-triketo-5β-cholanoic are inhibitors. Cholic exhibited competitive...
Abstract The blue‐green microalgae Spirulina, used in daily diets of natives Africa and America, have been found to be a rich natural source proteins, carotenoids, other micronutrients. Experimental studies animal models demonstrated an inhibitory effect Spirulina algae on oral carcinogenesis. Studies among preschool children India fusiformis (SF) effective dietary vitamin A. We evaluated the chemopreventive activity SF (1 g/day for 12 mos) reversing leukoplakia pan tobacco chewers Kerala,...
We conducted a double-blind placebo-controlled trial to evaluate the chemopreventive potential of either vitamin A alone or beta carotene in subjects with oral leukoplakia Kerala, India. randomised 160 fishermen and women precancerous lesions receive (retinyl acetate 300,000 IU/week x 12 months, n = 50), (360 mg/week 55), placebo (n 55). Blood, saliva urine samples were collected at baseline exit study serum micronutrients mutagenicity assays. Biopsies mucosal entry performed for...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation, identification, and specific localization of di-2-ethylhexyl phthalate in bovine heart muscle mitochondriaDarius J. Nazir, Aurora P. Alcaraz, Barbara A. Bierl, Morton Beroza, Padmanabhan NairCite this: Biochemistry 1971, 10, 23, 4228–4232Publication Date (Print):November 9, 1971Publication History Published online1 May 2002Published inissue 9 November...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Bile Acids. Some Observations the Intracellular Localization of Major Acids in Rat Liver*Tatsuo Okishio and Padmanabhan P. NairCite this: Biochemistry 1966, 5, 11, 3662–3668Publication Date (Print):November 1, 1966Publication History Published online1 May 2002Published inissue 1 November 1966https://doi.org/10.1021/bi00875a040RIGHTS & PERMISSIONSArticle Views83Altmetric-Citations75LEARN ABOUT THESE METRICSArticle Views are...
Abstract Human stool is a heterogeneous mixture of non‐digestible food residues, bacteria, cells exfoliated from the gastrointestinal mucosa and other secretory products. We have demonstrated that fresh human stools dispersed in buffered saline solution can be fractionated over Percoll/BSA gradients to yield 9 discrete bands density range p 1.033 1. 139 which could further purified Histopaque 1077. Enzyme‐linked immunoassays (ELISA) for colon‐specific antigen (CSA) cytokeratins (CK) were...
Objectives Heat shock protein 70 (HSP70) is overexpressed in human pancreatic cancer cell lines. To determine if serum HSP70 levels are elevated patients with and can function as a biomarker for early detection of cancer. Methods Study subjects were divided into 3 groups: histologically proven (PC; n = 23), chronic pancreatitis (CP; 12), matched normal control (C; 10). Serum determined using novel immunoelectrophoresis method developed validated by the authors. Significance difference...
Heme biosynthesis defect in vitamin E-deficient rats affecting bone marrow synthesis of delta- aminolevolinic acid and liver formation porphobilinogen
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGas Chromatographic Studies of Vitamins D2 and D3P. P. Nair, Corazon. Bucana, Stella. de Leon, D. A. TurnerCite this: Anal. Chem. 1965, 37, 6, 631–636Publication Date (Print):May 1, 1965Publication History Published online1 May 2002Published inissue 1 1965https://pubs.acs.org/doi/10.1021/ac60225a002https://doi.org/10.1021/ac60225a002research-articleACS PublicationsRequest reuse permissionsArticle Views176Altmetric-Citations54LEARN ABOUT THESE...
Human stools consist of a mixture undigested food residues, colonic microflora, and cellular components shed from the walls gastrointestinal tract. The are made up mostly terminally differentiated epithelial cells. Using combination Percoll density gradient centrifugation countercurrent centrifugal elutriation, it is now possible to recover these cells as an enriched fraction fresh human stools. Cells can be visualized on heat-fixed smears fractions stained with modified Wright's stain....