A5028901092- Chromosomal and Genetic Variations
- Genetic diversity and population structure
- Genetic Mapping and Diversity in Plants and Animals
- Genomics and Phylogenetic Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- DNA Repair Mechanisms
- Animal Genetics and Reproduction
- Evolution and Genetic Dynamics
- Prenatal Screening and Diagnostics
- Global Healthcare and Medical Tourism
- Animal Ecology and Behavior Studies
- Diverse Scientific Research in Ukraine
- Plant Reproductive Biology
- Genomics and Chromatin Dynamics
- Microtubule and mitosis dynamics
- Evolution and Paleontology Studies
- Bat Biology and Ecology Studies
- Iron oxide chemistry and applications
- Polar Research and Ecology
- Livestock and Poultry Management
- Cancer-related molecular mechanisms research
- Silk-based biomaterials and applications
- Genetic and Kidney Cyst Diseases
- Molecular Biology Techniques and Applications
- Diverse Aspects of Tourism Research
Institute of Cytology and Genetics
2010-2023
Novosibirsk State University
2008-2022
Siberian Branch of the Russian Academy of Sciences
2014-2021
Federal Scientific Center for Animal Husbandry named after Academician L.K. Ernst
2019
Institute of Systematics and Ecology of Animals
2018
Russian Academy of Sciences
2009-2013
Significance We discovered that contrary to other bird species and most animals, all examined songbird lineages contain a different number of chromosomes in the somatic germline genomes. Their germ cells have an additional germline-restricted chromosome (GRC). GRCs highly duplicated genetic material represented by repetitive elements sequences homologous unique regions genome. Surprisingly, even very closely related species, vary drastically size show little homology. hypothesize GRC was...
Abstract The Eurasian common shrew (Sorex araneus L.) is characterized by spectacular chromosomal variation, both autosomal variation of the Robertsonian type and an XX/XY1Y2 system sex determination. It important mammalian model genome evolution as it one few species with a complete sequence. Here we generate high-precision cytological recombination map for species, third such produced in mammals, following those humans house mice. We prepared synaptonemal complex (SC) spreads meiotic...
Abstract To make insight into the cytological basis of reproductive isolation, we examined chromosome synapsis and recombination in sterile male female hybrids between Microtus arvalis M. levis. These sibling species differ by a series chromosomal rearrangements (fusions, inversions, centromere shifts heterochromatin insertions). We found that meiosis was arrested at leptotene with complete failure pairing DNA double-strand breaks repair. In proceeded to pachytene; however, oocytes varied...
Abstract All songbirds studied to date have an additional Germline Restricted Chromosome (GRC), which is not present in somatic cells. GRCs show a wide variation genetic content and little homology between species. To check how this divergence affected the meiotic behavior of GRC, we examined synapsis, recombination copy number for closely related sand pale martins ( Riparia riparia R. diluta ) comparison with distantly estrildid finches. Using immunolocalization proteins FISH GRC-specific...
Hybrid sterility is an important step in the speciation process. Hybrids between dwarf hamsters Phodopus sungorus and P. campbelli provide a good model for studies cytological genetic mechanisms of hybrid sterility. Previous hybrids detected multiple abnormalities spermatogenesis high frequency dissociation X Y chromosomes at meiotic prophase. In this study, we found that autosomes males females underwent paring recombination as normally their parental forms did. The male showed...
Studies on mammals demonstrate wide interspecific variation in the number and distribution of recombination events along chromosomes. Birds represent an interesting model group for comparative analysis cytological ecological drivers rate evolution. Yet, data rates birds are limited to a dozen species. In this study, we used immunolocalization MLH1, mismatch repair protein marking mature nodules, estimate overall crossovers macrochromosomes female male meiosis gray goose (<i>Anser...
Heterochiasmy, a sex-based difference in recombination rate, has been detected many species of animals and plants. Several hypotheses about evolutionary causes heterochiasmy were proposed. However, there is shortage empirical data. In this paper, we compared related traits females males the barn swallow Hirundo rustica (Linnaeus, 1758), under strong sexual selection, with those pale martin Riparia diluta (Sharpe Wyatt, 1893), ecologically similar same karyotype (2N = 78), but without obvious...
Inversion heterozygotes are expected to suffer from reduced fertility and a high incidence of chromosomally unbalanced gametes due recombination within the inverted region. Non-homologous synapsis regions can prevent there diminish deleterious effects inversion heterozygosity. The choice between non-homologous homologous depends on size inversion, its genetic content, location in relation centromere telomere, background. In addition, is class inversions which gradually replaced by during...
Meiotic recombination is an important source of genetic variability. Studies on mammals demonstrate a substantial interspecies variation in overall rate, which dependent mainly chromosome (2n) and arm number (FN). Bird karyotypes are very conservative with 2n being about 78–82 FN 80–90 most species. However, some families such as Apodidae (swifts) Falconidae (falcons) show karyotypic variation. In this study, we describe the somatic pachytene male Common Swift (Apus apus) karyotype Eurasian...
Closely related mammalian species often have differences in chromosome number and morphology, but there is still a debate about how these relate to reproductive isolation. To study the role of rearrangements speciation, we used gray voles Alexandromys genus as model. These high level polymorphism substantial karyotypic divergence. We investigated testis histology meiotic behavior captive-bred colonies maximowiczii, mujanensis, two races evoronensis, their interracial interspecies hybrids,...
All songbirds studied so far have a germline-restricted chromosome (GRC), which is present in the germ cells and absent somatic cells. It shows wide variation size, morphology, genetic content between songbird species. In this paper, we analyzed GRC behavior female male meiosis of great tit, using immunolocalization meiotic proteins FISH with GRC-derived DNA probes. We found that, despite dozens million years independent evolution, tit displays striking similarity GRCs two species martins...
Korean field mouse (Apodemus peninsulae) shows a wide variation in the number of B chromosomes composed constitutive heterochromatin. For this reason, it provides good model to study influence centromeres and amount heterochromatin on spatial organization interphase nuclei. We analyzed three-dimensional fibroblast spermatocyte nuclei mice carrying different using laser scanning microscopy 3D fluorescence situ hybridization. detected co-localization with basic set. showed non-random...
We analyzed the synapsis and recombination between Z W chromosomes in oocytes of nine neognath species: domestic chicken Gallus gallus domesticus, grey goose Anser anser, black tern Chlidonias niger, common Sterna hirundo, pale martin Riparia diluta, barn swallow Hirundo rustica, European pied flycatcher Ficedula hypoleuca, great tit Parus major white wagtail Motacilla alba using immunolocalization SYCP3, main protein lateral elements synaptonemal complex, MLH1, mismatch repair marking...
Abstract The genome of flying birds, the smallest among amniotes, reflects overweight extensive DNA loss over unrestricted proliferation selfish genetic elements, resulted in a shortage repeated sequences and lack B-chromosomes. only exception this rule has been described zebra finch, which possesses large germ-line restricted chromosome (GRC), transmitted via oocytes, eliminated from male postmeiotic cells absent somatic cell. It is considered as rarity its origin, content function remain...
Hybrid zones between chromosome races of the common shrew (Sorex araneus) provide exceptional models to study potential role rearrangements in initial steps speciation. The Novosibirsk and Tomsk differ by a series Robertsonian fusions with monobrachial homology. They form narrow hybrid zone generate hybrids both simple (chain three chromosomes) complex eight or nine) synaptic configurations. Using immunolocalisation meiotic proteins, we examined pairing recombination males from zone....
Conspicuous phenotypic differences sometimes coexist with shallow genome-wide divergence between taxa. Along genomically localized selection and extensive gene flow, a high rate of meiotic recombination might contribute to such pattern; however, empirical evidence for the latter is lacking. We studied in white wagtail (Motacilla alba) – bird species showing plumage traits but little genomic differentiation, yet broadly incongruent geographical variation morphological genetic markers. found...