A5047373800- interferon and immune responses
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Spine and Intervertebral Disc Pathology
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
Johns Hopkins University
2022
Johns Hopkins Medicine
2022
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme as its primary infection mechanism. Interactions between S and endogenous proteins occur after but are not well understood. We profiled binding of against >9000 human found an interaction estrogen receptor α (ERα). Using bioinformatics, supercomputing, experimental assays, we identified a highly conserved functional nuclear coregulator (NRC) LXD-like motif on the S2...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme (ACE2) at the cell surface, which constitutes primary mechanism driving SARS-CoV-2 infection. Molecular interactions between transduced S and endogenous proteins likely occur post-infection, but such are not well understood. We used an unbiased screen to profile binding of full-length against >9,000 human found significant S-host interactions, including one estrogen receptor...
Abstract Background Rapid and accurate diagnosis of bacterial implant-associated spinal infection is essential for early intervention, surgical planning rational use antibiotics. While this predominantly caused by Gram positive bacteria, some patients are at high risk intestinal-derived negative bacteria. However, current diagnostic tools require invasive sampling with substantial risks to the patient. Moreover, conventional imaging, including computed tomography (CT), magnetic resonance...