A5032212627- Photonic and Optical Devices
- 3D Printing in Biomedical Research
- Photonic Crystals and Applications
- Quantum optics and atomic interactions
- Neuroscience and Neural Engineering
- Cell Image Analysis Techniques
- Neural dynamics and brain function
- Photoreceptor and optogenetics research
- Genetics, Aging, and Longevity in Model Organisms
- Zebrafish Biomedical Research Applications
- Advanced Fluorescence Microscopy Techniques
- Optical Network Technologies
- Plasmonic and Surface Plasmon Research
- Soft Robotics and Applications
- Gastrointestinal Bleeding Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Advanced Fiber Laser Technologies
- Neuroscience and Neuropharmacology Research
- Metabolomics and Mass Spectrometry Studies
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Nanofabrication and Lithography Techniques
- Cellular Mechanics and Interactions
- Memory and Neural Mechanisms
ETH Zurich
2015-2024
University of Zurich
2019-2024
SIB Swiss Institute of Bioinformatics
2019-2023
Massachusetts Institute of Technology
2009-2018
Broad Institute
2011
Moscow Institute of Thermal Technology
2010
In-Q-Tel
2010
Stanford University
2003-2007
Palo Alto University
2007
We show that light pulses can be stopped and stored coherently, with an all-optical adiabatic reversible pulse bandwidth compression process. Such a process overcomes the fundamental bandwidth-delay constraint in optics generate arbitrarily small group velocities for any given bandwidth, without coherent or resonant light-matter interactions. exhibit this optical resonators, where is accomplished only by refractive-index modulations performed at moderate speeds.
We introduce a new all-optical mechanism that can compress the bandwidth of light pulses to absolute zero, and bring them complete stop. The be realized in system consisting waveguide side coupled tunable resonators, which generates photonic band structure represents classical analogue electromagnetically induced transparency. same also achieve time-reversal operation. demonstrate operation such by finite-difference time-domain simulations an implementation crystals.
We report a suite of key microfluidic devices for complex high-throughput whole-animal genetic and drug screens. demonstrate high-speed sorter that can isolate immobilize Caenorhabditis elegans in well defined geometry screening phenotypic features at subcellular resolution physiologically active animals. show an integrated chip containing individually addressable screening-chamber incubation exposure individual animals to biochemical compounds high-resolution time-lapse imaging many on...
We demonstrate all-optical switching action in a nonlinear photonic crystal cross-waveguide geometry with instantaneous Kerr nonlinearity, which the transmission of signal can be reversibly switched on and off by control input. Our accomplishes both spatial spectral separation between regime. The device occupies small footprint few micrometers squared requires only milliwatts power at 10-Gbit/s rate use nonlinearity AlGaAs below half electronic bandgap. also show that dynamics, as revealed...
We present a bistable photonic crystal configuration consisting of waveguide sided coupled to single-mode cavity with instantaneous Kerr nonlinearity. show that such can generate extremely high contrast between the states in its transmission low input power. also provide an analytic theory completely account for entire transient switching dynamics, as revealed by finite difference time domain simulations.
We previously reported functional regeneration of Caenorhabditis elegans motor neurons after femtosecond laser axotomy. report here that multiple neuronal types can regrow axotomy using a variety lasers. The precise pattern regrowth varies with cell type, stage animal, and position Mechanosensory axons cut in late larval or adult stages displayed extensive regrowth, yet failed to reach their target area because guidance errors the anteroposterior axis. By contrast, mechanosensory early...
We introduce a mechanically tunable photonic crystal structure consisting of coupled slabs. Using both analytic theory, and first-principles finite-difference time-domain simulations, we demonstrate that strong variation transmission reflection coefficients light through such structures can be accomplished with only nanoscale the spacing between Moreover, by specifically configuring structures, high sensitivity preserved in spite significant fabrication-related disorders. expect to play...
Variants in the IMP2 (insulin-like growth factor 2 [IGF2] mRNA-binding protein 2) gene are implicated susceptibility to type diabetes. We describe ability of mammalian target rapamycin (mTOR) regulate cap-independent translation IGF2 mRNA through phosphorylation IMP2, an oncofetal RNA-binding protein. is doubly phosphorylated a rapamycin-inhibitable, amino acid-dependent manner cells and by mTOR vitro. Double promotes binding leader 3 5' untranslated region, translational initiation this...
Techniques for stable, rapid and repeatable small-animal immobilization are necessary high-throughput in vivo genetic/drug screens using cellular sub-cellular features multi-cellular organisms. We demonstrate a method non-invasive on-chip of physiologically active C. elegans without the use anesthesia or cooling, but with comparable stability even most demanding purposes. show observation manipulation immobilized animals two-photon microscopy femtosecond-laser microsurgery.
We introduce a new physical process that can perform complete time-reversal operation on any electromagnetic pulse. The uses only small refractive index modulations of linear optical elements. No nonlinear multiphoton effects such as four-wave mixing are required. introduced be implemented chip with standard semiconductor materials. Furthermore, the same used to compress or expand spectrum waves while completely preserving coherent information. exhibit by first-principles simulations...
We show that a planar metallic microcavity structure can exhibit an omnidirectional resonance, i.e., resonance for which the wavelength is independent of incidence angle light. The consists metal–dielectric–metal configuration. occurs when reflection phase shift cancels propagation shift. numerically demonstrate such in Ag–SiO2–Ag with realistic material parameters. Such omnidirectionally resonant structures are important all-angle efficiency enhancement light emitting diodes and photodetectors.
Discovery of molecular mechanisms and chemical compounds that enhance neuronal regeneration can lead to development therapeutics combat nervous system injuries neurodegenerative diseases. By combining high-throughput microfluidics femtosecond laser microsurgery, we demonstrate for the first time large-scale in vivo screens identification affect neurite regeneration. We performed thousands microsurgeries at single-axon precision nematode Caenorhabditis elegans a rate 20 seconds per animal....
We propose the use of interaction-free quantum measurements with electrons to eliminate sample damage in electron microscopy. This might allow noninvasive molecular-resolution imaging. show possibility such presence experimentally measured decoherence rates and using a scheme based on existing charged particle trapping techniques.
The zebrafish larva is an optically-transparent vertebrate model with complex organs that widely used to study genetics, developmental biology, and various human diseases. In this article, we present a set of novel technologies significantly increase the throughput capabilities our previously described automated screening technology (VAST). We developed robust multi-thread system can simultaneously process multiple animals. System limited only by image acquisition speed rather than fluidic...
Microarrays allowing simultaneous analysis of thousands parameters can significantly accelerate screening large libraries pharmaceutical compounds and biomolecular interactions. For large-scale studies on diverse biomedical samples, reliable, label-free, high-content microarrays are needed. In this work, using large-area plasmonic nanohole arrays, we demonstrate for the first time a label-free microarray technology with over one million sensors single microscope slide. A dual-color filter...
Background Generating autologous pluripotent stem cells for therapeutic applications will require the development of efficient DNA-free reprogramming techniques. Transfecting with in vitro-transcribed, protein-encoding RNA is a straightforward method directly expressing high levels proteins without genetic modification. However, long-RNA transfection triggers potent innate immune response characterized by growth inhibition and production inflammatory cytokines. As result, repeated causes...
Neurological drugs are often associated with serious side effects, yet drug screens typically focus only on efficacy. We demonstrate a novel paradigm utilizing high-throughput in vivo electrophysiology and brain activity patterns (BAPs). A platform high sensitivity records local field potentials (LFPs) simultaneously from many zebrafish larvae over extended periods. show that BAPs experiencing epileptic seizures or drug-induced effects have substantially reduced complexity (entropy), similar...
Abstract Non-invasive, molecularly-specific, focal modulation of brain circuits with low off-target effects can lead to breakthroughs in treatments disorders. We systemically inject engineered ultrasound-controllable drug carriers and subsequently apply a novel two-component Aggregation Uncaging Focused Ultrasound Sequence (AU-FUS) at the desired targets inside brain. The first sequence aggregates millimeter-precision by orders magnitude. second uncages carrier’s cargo locally achieve high...
We present a general analysis for the criteria to stop and store light coherently. show that pulse can be stopped in any physical system, provided (i) system bandwidth compressed zero; (ii) has sufficient degrees of freedom accommodate pulse, compression occurs while is system; (iii) done reversibly an adiabatic fashion preserves phase space information original photon during entire duration stopping process. Based upon this criterion, we brief discussion stopping-light schemes using atomic...