A5054328679- Bioinformatics and Genomic Networks
- Biomedical Text Mining and Ontologies
- Genomics and Phylogenetic Studies
- Genetics, Bioinformatics, and Biomedical Research
- Semantic Web and Ontologies
- Computational Drug Discovery Methods
- Complex Network Analysis Techniques
- Immunotherapy and Immune Responses
- Rheumatoid Arthritis Research and Therapies
- Data Visualization and Analytics
- Advanced Text Analysis Techniques
- Chromosomal and Genetic Variations
- Genomics and Rare Diseases
- Fungal and yeast genetics research
- Bacterial Genetics and Biotechnology
- Lipid metabolism and disorders
- Monoclonal and Polyclonal Antibodies Research
- Fractal and DNA sequence analysis
- Bone Metabolism and Diseases
- Gene Regulatory Network Analysis
- Advanced Proteomics Techniques and Applications
- Identification and Quantification in Food
- Neurobiology and Insect Physiology Research
- Genomics and Chromatin Dynamics
- Bacillus and Francisella bacterial research
University of Crete
2015-2025
University of Cyprus
2012-2019
Centre for Research and Technology Hellas
2012-2019
University of Hong Kong
2019
Innovative Research (United States)
2019
Stanford University
2019
Erasmus MC
2019
University of Luxembourg
2014
Hellenic Centre for Marine Research
2014
Foundation for Research and Technology Hellas
2014
Elucidating the content of a DNA sequence is critical to deeper understand and decode genetic information for any biological system. As next generation sequencing (NGS) techniques have become cheaper more advanced in throughput over time, great innovations breakthrough conclusions been generated various areas. Few these areas, which get shaped by new technological advances, involve evolution species, microbial mapping, population genetics, genome-wide association studies (GWAs), comparative...
The domain of Archaea has gathered significant interest for its ecological and biotechnological potential role in helping us to understand the evolutionary history Eukaryotes. In comparison bacterial domain, number adequately described members is relatively low, with less than 1000 species described. It not clear whether this solely due cultivation difficulty or, indeed, characterized by constraints that keep low. Based on molecular evidence bypasses difficulties formal characterization,...
Dehydroepiandosterone (DHEA), the most abundant steroid in humans, affects multiple cellular functions of endocrine, immune, and nervous systems. However, up to quite recently, no receptor has been described specifically for it, whereas its physiological actions have attributed conversion either androgens or estrogens. DHEA interacts modulate a variety membrane intracellular neurotransmitter receptors. We recently reported that protects neuronal cells against apoptosis, interacting with...
Nowadays, due to the technological advances of high-throughput techniques, Systems Biology has seen a tremendous growth data generation. With network analysis, looking at biological systems higher level in order better understand system, its topology and relationships between components is great importance. Gene expression, signal transduction, protein/chemical interactions, biomedical literature co-occurrences, are few examples captured representations where nodes represent certain...
Profiling of proteome dynamics is crucial for understanding cellular behavior in response to intrinsic and extrinsic stimuli maintenance homeostasis. Over the last 20 years, mass spectrometry (MS) has emerged as most powerful tool large-scale identification characterization proteins. Bottom-up proteomics, common MS-based proteomics approach, always been challenging terms data management, processing, analysis visualization, with modern instruments capable producing several gigabytes out a...
Text mining and data integration methods are gaining ground in the field of health sciences due to exponential growth bio-medical literature information stored biological databases. While such mostly try extract bioentity associations from PubMed, very few them dedicated other types repositories as chemical Herein, we apply a text approach on DrugBank database order explore drug based "Description", "Indication", "Pharmacodynamics" "Mechanism Action" fields. We Name Entity Recognition (NER)...
Finding, exploring and filtering frequent sentence-based associations between a disease biomedical entity, co-mentioned in disease-related PubMed literature, is challenge, as the volume of publications increases. Darling web application, which utilizes Name Entity Recognition to identify human-related terms articles, mentioned OMIM, DisGeNET Human Phenotype Ontology (HPO) records, generates an interactive entity association network. Nodes this network represent genes, proteins, chemicals,...
The iterative process of finding relevant information in biomedical literature and performing bioinformatics analyses might result an endless loop for inexperienced user, considering the exponential growth scientific corpora plethora tools designed to mine PubMed(®) related biological databases. Herein, we describe BioTextQuest(+), a web-based interactive knowledge exploration platform with significant advances its predecessor (BioTextQuest), aiming bridge processes such as bioentity...
Abstract Schizophrenia (SCZ) is a chronic, severe, and complex psychiatric disorder that affects all aspects of personal functioning. While SCZ has very strong biological component, there are still no objective diagnostic tests. Lately, special attention been given to epigenetic biomarkers in SCZ. In this study, we introduce three-step, automated machine learning (AutoML)-based, data-driven, biomarker discovery pipeline approach, using genome-wide DNA methylation datasets laboratory...
Abstract Rheumatoid arthritis (RA) is characterized by autoimmune joint destruction with debilitating consequences. Despite treatment advancements biologic therapies, a significant proportion of RA patients show an inadequate clinical response, and restoration immune self-tolerance represents unmet therapeutic need. We have previously described tolerogenic phenotype plasmacytoid dendritic cells (pDCs) in responding to anti–TNF-α agents. However, the molecular mechanisms involved...
By integrating phylogenomic and comparative analyses of 1104 high-quality genome sequences, we identify the core proteins lineage-specific fingerprint various evolutionary clusters (clades/groups/species) Bacillus genus. As fingerprints, denote those a certain lineage that are present only in particular absent any other lineage. Thus, these fingerprints expected to be involved adaptations Intriguingly, with few notable exceptions, majority species demonstrate rather low number...
ETS2 repressor factor (ERF) haploinsufficiency causes late-onset craniosynostosis (CRS) (OMIM entry 600775; CRS4) in humans, while mice Erf insufficiency also leads to a similar multisuture synostosis phenotype preceded by mildly reduced calvarium ossification. However, neither the cell types affected nor effects
The linguistic foundations of science and technology include many terms that have been borrowed from ancient languages. In the case with origins in Greek language, modern meaning can often differ significantly original one. Here we use PubMed database to demonstrate prevalence words origin language science, call for scientists exercise care when coining new terms.
Previous analyses have identified certain but limited evidence of recombination among HPV16 genomes, in accordance with a general perception that DNA viruses do not frequently recombine. In this evolutionary/bioinformatics study we analyzed more than 3600 publicly available complete and partial genomes. By studying the phylogenetic incongruence, similarity plots distribution patterns lineage-specific SNPs, identify several potential events between two major evolutionary clades. These clades...