A5069654789- Reproductive Physiology in Livestock
- Reproductive Biology and Fertility
- Human-Animal Interaction Studies
- Veterinary Equine Medical Research
- Animal Behavior and Welfare Studies
- Reproductive System and Pregnancy
- Rabies epidemiology and control
- RNA modifications and cancer
- RNA Research and Splicing
- Birth, Development, and Health
- Thin-Film Transistor Technologies
- Pregnancy and preeclampsia studies
- Semiconductor Lasers and Optical Devices
- Advanced Semiconductor Detectors and Materials
- Semiconductor Quantum Structures and Devices
- Alcoholism and Thiamine Deficiency
- RNA and protein synthesis mechanisms
- Molecular Biology Techniques and Applications
- Silicon Nanostructures and Photoluminescence
- Chronic Myeloid Leukemia Treatments
- Genetic and phenotypic traits in livestock
- COVID-19 Impact on Reproduction
- Silicon and Solar Cell Technologies
- Chronic Lymphocytic Leukemia Research
- Veterinary Medicine and Surgery
Hebrew University of Jerusalem
2013-2024
Johns Hopkins University
2024
Helicos Biosciences (United States)
2009-2015
Weizmann Institute of Science
2010-2013
Technion – Israel Institute of Technology
1997-2013
Eindhoven University of Technology
2013
Friedrich Miescher Institute
2013
Washington University in St. Louis
2012
Yale University
2012
University of Saskatchewan
2006-2011
Discovery that the transcriptional output of human genome is far more complex than predicted by current set protein-coding annotations and most RNAs produced do not appear to encode proteins has transformed our understanding complexity suggests new paradigms regulation. However, fraction all cellular RNA whose function we understand utilized produce remain controversial. This simply a bookkeeping issue because degree which this un-annotated transcription present important implications with...
BACKGROUND. The significant risks posed to mothers and fetuses by COVID-19 in pregnancy have sparked a worldwide debate surrounding the pros cons of antenatal SARS-CoV-2 inoculation, as we lack sufficient evidence regarding vaccine effectiveness pregnant women their offspring. We aimed provide substantial for effect BNT162b2 mRNA versus native infection on maternal humoral, well transplacentally acquired fetal immune response, potentially providing newborn protection.
Abstract The recent COVID-19 pandemic led to uncertainty and severe health economic concerns. Previous studies indicated that owning a companion animal, such as dog or cat, has benefits for good mental health. Interactions with animals may help depression anxiety, particularly under stress-prone conditions. Human–animal interactions even improve peer-to-peer social relationships, well enhance feelings of respect, trust, empathy between people. Interestingly, it also been shown stress poor...
RNA Seq provides unparalleled levels of information about the transcriptome including precise expression over a wide dynamic range. It is essential to understand how technical variation impacts quality and interpretability results, potential errors could be introduced by protocol, source affects transcript detection, all these variations can impact conclusions drawn. Multiple human samples were used assess fragmentation, fractionation, cDNA synthesis, single versus multiple tag counting....
Shape transformations of partially capped self-assembled InAs quantum dots grown on InP are studied. Atomic force microscopy images show large anisotropic redistribution the island material after coverage by a 1 nm thick layer. The occurs within few minutes and leads to change from lens-like elongated ring-like islands. shape transformation is not accompanied dot compositional change. formation InAs/InP rings disagrees with previous model InAs/GaAs ring that assumes driving for difference in...
Abstract Estrogen receptor (ER)α-positive tumors are commonly treated with ERα antagonists or inhibitors of estrogen synthesis, but most develop resistance, and we need to better understand the pathways that underlie proliferative tumorigenic role this estrogen-activated transcription factor. We here present first single-molecule sequencing estradiol-induced transcriptome in luminal A-type human breast cancer cell lines MCF7 T47D. Sequencing libraries were prepared from polyadenylated RNA...
Significance Fluid motion measurements can provide valuable insight regarding the structure and function of developing placentas. This study presents to our knowledge first MRI characterization multicompartmental diffusion incoherent flow in pregnant mice at different gestation stages, made possible by methods herein introduced for single-scan acquisition diffusion-encoded images challenging environment associated with vivo embryonic studies. These were combined a customized contrast agent...
Post-partum metritis is among the most prevalent disease in dairy cows affecting animal welfare and inflicting considerable economic loses. While post-partum contamination of uterus rife cows, only a fraction these animals will develop metritis. Our main objective was to compare bacterial communities inflammatory response endometrium healthy metritic cows. Holstein-Friesian (n = 35) were sampled immediately following clinical classification as 21), suffering from 13) or septic 1), based on...
The second wave of next generation sequencing technologies, referred to as single-molecule (SMS), carries the promise profiling samples directly without employing polymerase chain reaction steps used by amplification-based (AS) methods. To examine merits both we mRNA results from and in a set human cancer cell lines tissues. We observe characteristic coverage bias towards high abundance transcripts sequencing. A larger fraction AS reads cover highly expressed genes, such those associated...
Ovulation and inflammation share common attributes, including immune cell invasion into the ovary. The present study aims at deciphering role of dendritic cells (DCs) in ovulation corpus luteum formation. Using a CD11c-EYFP transgenic mouse model, ovarian transplantation experiments, fluorescence-activated sorting analyses, we demonstrate that CD11c-positive, F4/80-negative cells, representing DCs, are recruited to ovary under gonadotropin regulation. By conditional ablation these CD11c-DTR...
Thiamine responsive megaloblastic anemia (TRMA) is an autosomal recessive disorder with a triad of symptoms: anemia, deafness, and non-type 1 diabetes mellitus. Occasionally, cardiac abnormalities the optic nerve retina occur as well. Patients TRMA often respond to treatment pharmacological doses thiamine. Recently, mutations were found in patients thiamine transporter gene (SLC19A2). We here describe eight additional families. four novel three that previously described. Of ones, one...
A crucial event in animal development is the specification of primordial germ cells (PGCs), which become stem that create sperm and eggs. How PGCs are created provides a valuable paradigm for understanding general. We find sea urchin Strongylocentrotus purpuratus exhibit broad transcriptional repression, yet enrichment set inherited mRNAs. Enrichment several germline determinants requires RNA-binding protein Nanos to target transcript encodes CNOT6, deadenylase, degradation PGCs, thereby...
Objective To determine the influence of 3 perfusate volumes on amikacin concentration in metacarpophalangeal joint following cephalic regional limb perfusion (RLP) standing horses. Animals Seven healthy Methods Three (100, 60, and 30 mL), containing 2 grams amikacin, were tested during intravenous RLP at vein, placing tourniquet mid antebrachium, sedated Synovial fluid was collected from before 120 minutes after perfusion. Serum samples taken jugular vein same time points. Samples analyzed...
Angiogenesis and lymphangiogenesis are key processes during embryogenesis as well under physiological pathological conditions. Vascular endothelial growth factor C (VEGFC), the ligand for both VEGFR2 VEGFR3, is a central lymphangiogenic regulator that also drives angiogenesis. Here, we report members of highly conserved BACH (BTB CNC homology) family transcription factors regulate VEGFC expression, through direct binding to its promoter. Accordingly, down-regulation bach2a hinders blood...
Abstract Food-animal welfare is a major ethical and social concern. Pork the most consumed meat worldwide, with over billion pigs slaughtered annually. Most of these routinely undergo painful surgical procedures (surgical castration, tail docking, teeth clipping), which farmers often reluctant to avoid, claiming it would increase cost reduce production efficiency. Herein, this study indicates that compromise pigs’ health condition. Replacing castration immunocastration, avoiding docking...
In mammalian pregnancy, maternal cardiovascular adaptations must match the requirements of growing fetus(es), and respond to physiologic pathologic conditions. Such are particularly demanding for mammals bearing large-litter pregnancies, with their inherent conflict between interests each individual fetus welfare entire progeny. The mouse is most common animal model used study development genetics, as well pregnancy-related diseases. Previous studies suggested that in mice, blood flow...
Abstract Noninvasive imaging is a critical part of the study developing embryos/fetuses, particularly in context alterations gene expression genetically modified animals. However, litter‐bearing animals, such as mice, inability to accurately identify individual embryo/fetus utero major obstacle longitudinal, noninvasive vivo studies. Arterial spin labeling MRI was adopted here determine fetal order along uterine horns vivo, based on specific pattern dual arterial blood supply within mouse...