A5085868897- Liver Disease Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- Alcohol Consumption and Health Effects
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Trace Elements in Health
- Electroconvulsive Therapy Studies
- Diet, Metabolism, and Disease
- Pharmacological Effects and Toxicity Studies
- Renal Transplantation Outcomes and Treatments
- Intensive Care Unit Cognitive Disorders
- Epilepsy research and treatment
- Gallbladder and Bile Duct Disorders
- Iron Metabolism and Disorders
- Intestinal and Peritoneal Adhesions
- Full-Duplex Wireless Communications
- Mechanical Circulatory Support Devices
- Diabetes Treatment and Management
- SARS-CoV-2 detection and testing
- Kawasaki Disease and Coronary Complications
- Polyomavirus and related diseases
- Appendicitis Diagnosis and Management
University of Plymouth
2020-2023
University Hospitals Plymouth NHS Trust
2020-2023
Eijkman Institute for Molecular Biology
2021
Nottingham University Hospitals NHS Trust
2014-2021
University of Nottingham
2018-2021
Nepal Health Research Council
2021
NIHR Clinical Research Network
2021
National Institute for Health Research
2021
National Records of Scotland
2021
Intensive Care National Audit & Research Centre
2021
Increasing rates of liver transplantation and improved outcomes have led to greater numbers transplant recipients followed up in non-transplant centres. Our aim was document long-term clinical managed this 'hub-and-spoke' healthcare model.
Objective Primary biliary cholangitis (PBC) is a progressive, autoimmune, cholestatic liver disease affecting approximately 15 000 individuals in the UK. Updated guidelines for management of PBC were published by The European Association Study Liver (EASL) 2017. We report on first national, pilot audit that assesses quality care and adherence to guidelines. Design Data collected from 11 National Health Service hospitals England, Wales Scotland between 2017 2020. patient demographics,...
Abstract Background and Aim Alcoholic hepatitis (AH), a severe complication of long‐term alcohol misuse, has 30% 90‐day mortality. Infections are common associated with higher There is currently no accurate method to predict infection in these patients. We aimed test measure immune function, the QuantiFERON Monitor (QFM), predicting clinical outcomes patients AH. Methods Peripheral blood was taken at baseline, QFM performed according manufacturer's instructions. In parallel, samples were...
A 65-year-old man presented with a 6-week history of increasing confusion associated cognitive decline. Empirical antibiotic cover for urinary tract infection was prescribed no response. After exhaustive radiological and pathological investigations were carried out, diagnosis John Cunningham virus encephalopathy made. This case report describes the varied clinical presentation symptoms their management options, along latest opinions behind them.
A 20-year-old woman presented with severe lactic acidosis. All investigations have proven negative until we discover the culprit - topiramate, which she takes for cluster headaches. J Med Cases. 2014;5(12):634-635 doi: http://dx.doi.org/10.14740/jmc1984w
A 20-year-old woman presented with severe lactic acidosis. All investigations have proven negative until we discover the culprit - topiramate, which she takes for cluster headaches. J Med Cases. 2014;5(12):634-635 doi: http://dx.doi.org/10.14740/jmc1984w
Uterine sarcomas are a rare form of uterine cancer. Their ultrasound features may simulate benign lesions. We present the findings in three cases. A 46-year-old female with medical history hypothyroidism and was on treatment thyroxine. She presented complaint dysmenorrhoea for five months. Ultrasound scan demonstrated 2.5 cm solid area, suggestive polyp, endometrial cavity. Repeat month later showed cavity to be empty. After lapse one year, she turned up complaining menorrhagia. An which...
The efficacy of EUS-CPB in the pain management pancreatic cancer and chronic pancreatitis is 72% 51% respectively. pancreato-biliary but with normal investigations has not yet been reported. We report results a single centre retrospective observational study on safety above condition.
<h3>Background and Aims</h3> Chronic alcohol use generates reactive oxygen species (ROS) through the CYP2E1 pathway contributes to pathogenesis of alcohol-related liver disease (ALD). However, understanding role ROS in alcoholic hepatitis (AH) is lacking. We aimed measure oxidative stress well-defined cohort ALD AH patients compare with healthy subjects using a well-validated reproducible assay. <h3>Method</h3> Patients from University Hospitals Plymouth (new jaundice, coagulopathy, heavy...
<h3>Background</h3> Severe alcoholic hepatitis (SAH) is an orchestrated inflammatory liver condition driven by immune dysfunction that results in failure and death 30% within 90 days. Improved understanding of the mechanisms may identify new targets for therapy. In other diseases, oxidative stress alters epigenetic regulation genes through changes expression histone deacetylases (HDACs) acetyltransferases (HATs). We aimed to determine whether HDAC/HAT function are associated with outcome...
<h3>Background and Aims</h3> Alcohol is known to indirectly influence immune function through epigenetic regulation, but if this has an impact on alcoholic hepatitis (AH) remains unknown. The Histone deacetylase (HDACs) histone acetylase (HATs) gene families differentially regulate accessibility key pro- anti-inflammatory transcription factors, a mechanism for control. We hypothesised that differential expression of HDAC HAT genes may susceptibility outcome from AH. <h3>Method</h3> Patients...