A5057867590- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Myofascial pain diagnosis and treatment
- Pain Management and Placebo Effect
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Migraine and Headache Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Intestinal and Peritoneal Adhesions
- Peripheral Neuropathies and Disorders
- Hernia repair and management
- Pediatric Pain Management Techniques
- Nerve injury and regeneration
- Ophthalmology and Eye Disorders
- Sympathectomy and Hyperhidrosis Treatments
- Advancements in Transdermal Drug Delivery
- Anesthesia and Pain Management
- Pain Management and Treatment
- Medical and Biological Sciences
- Spine and Intervertebral Disc Pathology
- Complementary and Alternative Medicine Studies
- Surgical Sutures and Adhesives
- Ion channel regulation and function
- Acupuncture Treatment Research Studies
- Therapeutic Uses of Natural Elements
Temple University
2021-2022
Harbage Consulting
2022
University of New England
2010-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Ministry of Interior
2019
Università Cattolica del Sacro Cuore
2019
University of Sussex
2019
New England College
2010-2018
UNSW Sydney
2014-2015
St Vincent's Clinic
2014
A variety of seemingly diverse pain syndromes are characterized by movement-induced radiating in the distribution a peripheral nerve or root. This could be explained induction ectopic mechanical sensitivity intact sensory axons. Here we show that inflammation led to axons subset mechanically sensitive primary neurons. Dorsal root recordings were made from 194 neurons innervated deep and cutaneous structures had C, Aδ, Aαβ conduction velocities. No any category control experiments. However,...
Context.—Episodic tension-type headache is common and often treated using manual therapies. Few data exist for the efficacy of these interventions.Objective.—To determine effects spinal manipulation therapy on adults with episodic headache.Design.—Randomized controlled trial lasting 19 weeks.Setting.—Outpatient facility a National Health Service–funded chiropractic research institution in Denmark.Participants.—Volunteer sample 26 men 49 women aged 20 to 59 years who met diagnostic criteria...
Bove, Geoffrey M. and Michael A. Moskowitz. Primary Afferent Neurons Innervating Guinea Pig Dura. J. Neurophysiol. 77: 299–308, 1997. We made recordings from filaments of guinea pig nasociliary nerve to study response properties afferent axons innervating the anterior superior sagittal sinus surrounding dura mater. analyzed 38 units in 14 experiments. Units were initially located with use mechanical stimuli, then characterized by their conduction velocity sensitivities mechanical, thermal,...
1. We made recordings from rat dorsal root filaments to study unmyelinated afferent units (conduction velocity < or = 1.5 m/s) associated with deep paraspinal tissues of the sacrum and proximal tail. Data 57 were analyzed in 47 experiments. Receptive fields identified intact animals then surgically isolated using microdissection. Units characterized mechanical, noxious chemical, thermal stimuli. 2. These revealed innervation nerve sheaths surrounding connective tissue, muscles, tendons,...
Painful and disabling musculoskeletal disorders remain prevalent. In rats trained to perform repetitive tasks leading signs dysfunction similar those in humans, we tested whether manual therapy would prevent the development of pathologies symptoms. We collected behavioral, electrophysiological, histological data from control rats, that for 5 weeks before performing a high-repetition high-force (HRHF) task 3 untreated, performed while being treated 3x/week using modeled (MMT) forearm (HRHF +...
Background: Thousands of athletes perform kipping handstand push-ups (kHSPUs). The safety kHSPUs has been questioned because vertical impacts upon the head, but no previous study examined ground reaction forces sustained during these exercises.Aims: This exploratory, observational cross-sectional measured exerted on head and supported by neck (kHSPU). goal was to compare with known thresholds that can damage cervical spine. researcher also aimed determine how often people experience symptoms...
Peripheral nerve inflammation can cause axons conducting through the inflamed site to become mechanically sensitive. Axonal mechanical sensitivity (AMS) of intact may explain symptoms in a diverse number conditions characterized by radiating pain evoked movements affected nerve. Because also disrupts axoplasmic transport, we hypothesized that disruption transport could cellular components responsible for transduction accumulate and inserted at site, causing AMS. This was tested examining AMS...
Abstract Recent evidence suggests that substance P (SP) is up‐regulated in primary sensory neurons following axotomy and this change occurs larger do not usually produce SP. If so, then the up‐regulation may allow normally neighboring, uninjured, nonnociceptive dorsal root ganglion (DRG) to become effective activating pain pathways. By using immunohistochemistry, we performed a unilateral L5 spinal nerve transection on male Wistar rats measured SP expression ipsilateral L4 DRGs contralateral...
We examined the effectiveness of a manual therapy consisting forearm skin rolling, muscle mobilization, and upper extremity traction as preventive treatment for rats performing an intensive lever-pulling task. hypothesized that this would reduce task-induced neuromuscular tendon inflammation, fibrosis, sensorimotor declines.Sprague-Dawley performed reaching lever pulling task food reward, 2 h/day, 3 days/week, 12 weeks, while simultaneously receiving times per week weeks to either...
Noxious heat may act as an endogenous activator of the ionotropic capsaicin receptor (VR1) and its recently found homologue VRL1, expressed in rat dorsal root ganglion cells present along their nerve fibres. We have previously reported that induces receptor-mediated Ca++-dependent calcitonin gene-related peptide (CGRP) release from axons isolated sciatic nerve. Here we extended investigation to noxious stimulation transduction mechanisms involved. Heat augmented CGRP desheathed nerves a...
Postoperative adhesions are pathological attachments that develop between abdominopelvic structures following surgery. Considered unavoidable and ubiquitous, postoperative lead to bowel obstructions, infertility, pain, reoperations. As such, they represent a substantial health care challenge. Despite over century of research, no preventive treatment exists. We hypothesized from lack movement the organs in immediate period while rendered immobile by surgery opiates, tested whether manual...