A5088846866- Genomics and Phylogenetic Studies
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Probiotics and Fermented Foods
- Silk-based biomaterials and applications
- DNA and Nucleic Acid Chemistry
- Aquaculture disease management and microbiota
- Microbial Natural Products and Biosynthesis
- Antimicrobial Peptides and Activities
- Enzyme Production and Characterization
- Adhesion, Friction, and Surface Interactions
- Surface Modification and Superhydrophobicity
- Biochemical and Structural Characterization
- CRISPR and Genetic Engineering
Keio University
2023-2024
Japan Advanced Institute of Science and Technology
2020-2023
Spider silk is considered a promising next-generation biomaterial due to its exceptional toughness, coupled with renewability and biodegradability. Contrary the conventional view that spider mainly composed of two types proteins (spidroins), MaSp1 MaSp2, multi-omics strategies are increasingly revealing inclusion complex components confers higher mechanical properties material. In this review, we focus on several recent findings report essential mechanisms necessary reproduce natural silk....
The major ampullate silk of orb-weaving spiders is renowned for its exceptional mechanical properties, including high tensile strength and extensibility. development artificial spider presents a promising alternative to traditional fibers with significant environmental impacts. This study aims elucidate the relationship between sequence motifs natural properties silk. Using Spider Silkome Database, we identified correlated specific physical substituted them into MaSp2-based mini-spidroin...
The regulation of DNAzyme activity is an important problem for its in vivo applications. We achieved photochemical by using reversible DNA photo-crosslinking 3-cyanovinylcarbazole (CNV K). ODN containing CNV K photo-crosslinked to a pyrimidine base the complementary strand after few seconds photoirradiation, and photoadduct was split photoirradiation another wavelength. with completely inhibited (OFF state). In contrast, 312 nm irradiation, recovered upon addition substrate (ON addition,...
Atopobiaceae sp. strain P1 ( Actinobacteria , Coriobacteriales ) was isolated from mouse feces. Here, we report the complete genome sequence of this strain, which has a total size 2,028,478 bp and G+C content 58.6%.
Abstract Double duplex invasion (DDI) DNA is a useful antigene method that inhibits expression of genomic DNA. We succeeded in performing photoinduced‐DDI (pDDI) using ultrafast photo‐cross‐linking. 5‐Cyanouracil ( CN U) has been used pDDI to inhibit photo‐cross‐linking between probes, but its importance not clarified. Therefore, this study, we evaluated the effect spacer (S) and d‐spacer (dS) exhibit ability similar U. U exhibited highest efficiency, S, dS, T were very different. The...
Lysobacter species produce lysobactin, a depsipeptide antibiotic that is effective against methicillin-resistant Staphylococcus aureus and vancomycin-resistant . Here, we report complete genome sequences of two strains, which were isolated from seawater ( caseinilyticus ) soil helvus in South Korea.
A mesophilic bacterium Actinoplanes sichuanensis strain 03-723T was previously isolated from soil by Sun et al. Here, we present a complete and annotated genome sequence of this strain, which has total size 12.1 Mbp with G + C content 70.1%.