A5028148008- Fungal Infections and Studies
- Mosquito-borne diseases and control
- Antifungal resistance and susceptibility
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 epidemiological studies
- Viral Infections and Outbreaks Research
- COVID-19 diagnosis using AI
- Machine Learning in Healthcare
- Parasitic Infections and Diagnostics
- Bacterial Identification and Susceptibility Testing
- COVID-19 and Mental Health
- Polyomavirus and related diseases
- Diphtheria, Corynebacterium, and Tetanus
- Prion Diseases and Protein Misfolding
- Microbial Metabolism and Applications
- T-cell and Retrovirus Studies
- Biosensors and Analytical Detection
- Data-Driven Disease Surveillance
- Hepatitis Viruses Studies and Epidemiology
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Autoimmune Neurological Disorders and Treatments
Auxilio Mutuo Hospital
2021-2024
University of Puerto Rico System
2006-2022
Amref Health Africa
2022
University of Puerto Rico, Medical Sciences Campus
2016
Walter Reed Army Institute of Research
2015
Clinical Research Puerto Rico
2015
GlaxoSmithKline (United States)
2015
Ponce Health Sciences University
2015
GlaxoSmithKline (Belgium)
2015
To estimate the frequency and duration of detectable Zika virus (ZIKV) RNA in human body fluids, we prospectively assessed a cohort newly infected participants Puerto Rico.We evaluated samples obtained from 150 (including 55 men) whom ZIKV was detected on reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay urine or blood an enhanced arboviral clinical surveillance site. We collected serum, urine, saliva, semen, vaginal secretions weekly for first month then at 2, 4, 6 months. All...
The representativeness and timeliness of sentinel surveillance for endemic emerging arboviral respiratory diseases in low-resource settings are understudied. We compared laboratory-confirmed epidemic dengue, non-epidemic Zika, chikungunya, COVID-19 (pre-Omicron Omicron periods) cases reported Puerto Rico's Sentinel Enhanced Dengue Surveillance System (SEDSS) with island-wide trends by the Department Health's passive disease system (PADSS). plotted over time to assess used lagged...
This was a double-blind, randomized, controlled, phase II clinical trial, two dose study of re-derived, live-attenuated, tetravalent dengue virus (TDEN) vaccine (two formulations) or placebo in subjects 1-50 years age. Among the 636 enrolled, 331 (52%) were primed, that is, baseline seropositive to at least one (DENV) type. Baseline seropositivity prevalence increased with age (10% [< 2 years], 26% [2-4 60% [5-20 and 93% [21-50 years]). Safety profiles TDEN vaccines similar regardless...
Dengue and influenza are pathogens of global concern cause febrile illness similar to COVID-19. We analyzed data from an enhanced surveillance system operating three emergency departments urgent care clinic in Puerto Rico identify clinical features predictive or dengue compared with Participants fever respiratory symptoms aged ≥18 years enrolled May 2012-January 2021 dengue, influenza, SARS-CoV-2 confirmed by reverse transcriptase polymerase chain reaction were included. calculated adjusted...
ABSTRACT Background The COVID‐19 pandemic underscored the need for rapid and accurate diagnostic tools. In August 2020, Abbott BinaxNOW Antigen Card test became available as a timely affordable alternative SARS‐CoV‐2 molecular testing, but its performance may vary due to factors including timing symptomatology. This study evaluates in diverse epidemiological contexts. Methods Using RT‐PCR reference, we assessed of detection anterior nasal swabs from participants two studies Puerto Rico...
BK virus nephropathy (BKVN) is an increasingly recognized cause of kidney allograft loss and thought to be related the newer, more potent immunosuppressive agents. Conflicting information has been reported on risk factors for infection.To determine incidence, associated factors, outcome BKVN in our transplant population order improve identification management.Kidney transplants from January 2000 December 2005 were retrospectively reviewed. Data collected patients with biopsy-proven including...
E. Colón‐Santos, M. González‐Ramos, J. Bertrán‐Pasarell, G. Rodríguez‐Vega, Almira‐Suarez, R. Vélez‐Rosario. Disseminated nocardiosis masking an atypical zygomycosis presentation in a kidney transplant recipient. Transpl Infect Dis 2011: 13: 380–384. All rights reserved Abstract: Immunosuppressive agents increase the vulnerability of solid organ patients to opportunistic infections. An clinical bacterial and fungal co‐infection makes diagnosis treatment even more challenging this population....
Abstract Introduction Covid-19 is a triphasic disorder first typified by viral phase that lasts from the onset of symptoms until seven days later. This followed second and third phase, initially characterized appearance lung infiltrates, in 20% respiratory failure. The usually heralded an elevation serologic inflammatory markers including CRP, ferritin, IL-6, LDH as well D-dimers. Approximately proceed to are then treated with dexamethasone, provided they oxygen-dependent since these only...
Hispanics are the majority ethnic population in Puerto Rico where we reviewed charts of 109 hospitalized COVID-19 patients to better understand demographic and clinical characteristics determine risk factors for poor outcomes. Eligible medical records with confirmed illnesses were at four participating hospitals centers across data abstracted that described course, interventions, We found had a median 3 underlying conditions obesity diabetes as most frequently reported conditions. Intensive...
Abstract Background Covid-19 is a triphasic disorder characterized by viral phase lasting 7-10 days from first onset of symptoms. In approximately 20% it followed second stage heralded elevation pro-inflammatory markers such as ferritin, IL-6, CRP, LDH and D-dimers. We hypothesized that those with few abnormalities would have low risk for progression to respiratory insufficiency could be monitored at home without treatment. Methods Inclusion criteria included age >21, O 2 saturation...
Herpes simplex virus, an uncommon etiologic agent causing hepatitis, has been described in immunosuppressed, neonates, or pregnant patients as a fulminant disease with relentless and fatal course untreated individuals. Nonspecific signs symptoms such fever, anorexia, nausea, vomiting, abdominal pain, mucocutaneous lesions, elevations of aminotransferases, leukopenia characterize herpetic hepatitis. We present case hepatic failure secondary to herpes virus 35-year-old woman human...
Background:The ongoing pandemic of coronavirus disease 2019 has shattered the entire world with 4.55 million deaths.In order to develop proper containment strategy, there is a pressing need insights about real proportions SARS-CoV-2 infected persons among total population any country or community.Although role antibody assay system been no help for diagnosis infection, utility testing epidemiological purposes remains an open field.Methods: In this study, we used three different commercial...
Covid-19 is a triphasic disorder first typified by viral phase that lasts from the onset of symptoms until approximately 7 days later.This followed second considered as inflammatory stage, characterized appearance lung infiltrates, which can result in hypoxemia [1][2][3][4].This usually heralded an elevation serologic markers such C-reactive protein (CRP), ferritin, interleukin-6 (IL-6) [5], LDH (lactic dehydrogenase) well D-dimers [4,6,7].In smaller subset cases this third consisting...