A5006506469- Diabetes and associated disorders
- Pancreatic function and diabetes
- Diabetes Management and Research
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Diverse Approaches in Healthcare and Education Studies
- High Altitude and Hypoxia
- Heavy Metal Exposure and Toxicity
- Health Sciences Research and Education
- Hematopoietic Stem Cell Transplantation
- Research in Social Sciences
- Physical Education and Training Studies
- Muscle metabolism and nutrition
- Social and Educational Sciences
- Pancreatitis Pathology and Treatment
- Enzyme Structure and Function
- Enzyme Production and Characterization
- Cancer Research and Treatments
- Arsenic contamination and mitigation
Goethe University Frankfurt
2012-2025
Benaroya Research Institute
2022-2024
Virginia Mason Medical Center
2022-2024
Translational Research Institute
2023
La Jolla Institute for Immunology
2020-2021
Maine Medical Center
2016-2017
University Hospital Frankfurt
2012-2016
University of Würzburg
1978
Abstract Context The value of continuous glucose monitoring (CGM) for autoantibody (AAB)-positive individuals in clinical trials progression type 1 diabetes (T1D) is unknown. Objective Compare CGM with oral tolerance test (OGTT)–based metrics prediction T1D. Methods At academic centers, OGTT and data from multiple-AAB relatives were evaluated associations T1D diagnosis. Participants multiple-AAB–positive a TrialNet Pathway to Prevention (TN01) ancillary study (n = 93). intervention was week...
CD4 + CD25 hi CD127 lo/− FOXP3 regulatory T cells (T regs ) play a key role in preventing autoimmunity. In autoimmune type 1 diabetes (T1D), adoptive transfer of autologous polyclonal has been shown to be safe adults phase clinical trials. We explored factors contributing efficacy expanded (expT randomized 2 multi-center, double-blind, trial (Sanford/Lisata Therapeutics T-Rex trial, ClinicalTrials.gov NCT02691247). One hundred ten treated children and adolescents with new-onset T1D were...
Preproinsulin-specific CD8 + T cells residing in the exocrine pancreas become attracted to islets type 1 diabetes.
Type 1 diabetes (T1D) is precipitated by the autoimmune destruction of insulin-producing β-cells in pancreatic islets Langerhans. Chemokines have been identified as major conductors islet infiltration autoaggressive leukocytes, including antigen-presenting cells and autoantigen-specific T cells. We previously generated a roadmap gene expression microenvironment during T1D mouse model found that most chemokine axes are chronically upregulated T1D. The XCL1/XCR1 axis particular interest, since...
Abstract Background Essentially all individuals with multiple autoantibodies will develop clinical type 1 diabetes. Multiple (AABs) and normal glucose tolerance define stage diabetes; abnormal defines 2. However, the rate of progression within these stages is heterogeneous, necessitating personalized risk calculators to improve implementation. Methods We developed 3 models using TrialNet's Pathway Prevention data accommodate reality that not variables are clinically available. The small...
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing β-cells in pancreas. Thereby, chemokine CXC-motif ligand 10 (CXCL10) plays an important role recruitment autoaggressive lymphocytes to islets Langerhans. Transplantation isolated as a promising therapy for T1D has been hampered by early graft rejection. Here, we investigated influence CXCL10 on islet isografts using RIP-LCMV mice expressing lymphocytic choriomeningitis virus (LCMV) protein β-cells. express...
Interleukin (IL)-22 is a cytokine displaying tissue protective and pro-regenerative functions in various preclinical disease models. Anti-bacterial, pro-proliferative, anti-apoptotic properties mediated by activation of the transcription factor signal transducer activator (STAT)-3 are key to biological this IL-10 family member. Herein, we introduce RINm5F insulinoma cells as rat β-cell line that, under influence IL-22, displays STAT3 with induction its downstream gene targets Socs3, Bcl3,...
The presence of islet autoimmunity identifies individuals likely to progress clinical type 1 diabetes (T1D). In research studies, autoantibody screening followed by regular metabolic monitoring every 6 months reduces incidence diabetic ketoacidosis (DKA) at diagnosis.
Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta-cells in pancreas. The chemokine CXCL10 seems to play an important role recruitment autoaggressive lymphocytes islets Langerhans Diabetes (T1D). Since transplantation isolated is a promising therapy T1D, but has been hampered by fact that islet grafts get rejected even presence immunosuppressive regimen, we intended investigate possible influence on rejection process.
HealthyChildren.org: www.healthychildren.org Description: Developed by the American Academy of Pediatrics (AAP), HealthyChildren.org is a parenting Web site and extension AAP. The articles are written edited expert pediatricians further reviewed an editorial advisory board on regular basis to reflect current AAP guidelines standards care. It source for broad spectrum information related pediatric health issues guidance. Of particular interest two sports medicine-related pages. Under Healthy...
Abstract Type 1 diabetes (T1D) is an autoimmune disease marked by immune destruction of insulin-producing β-cells the pancreas. In effort to halt progression, autologous polyclonal expanded regulatory T cells (expTregs) were adoptively transferred into adolescents with recent-onset T1D (Sanford/Lisata Therapeutics Trex Phase 2 clinical trial, NCT02691247). Overall, expTreg therapy (1–24×10 6cells/kg) did not preserve residual β-cell function, as measured change in insulin C-peptide AUC-mean...
Radsource: MRI Web Clinic www.radsource.us/category/web-clinic/ Description: Radsource was founded in 2001 and has been marketed to hospitals medical practices of all sizes, offering a unique picture archiving communication system (PACS) call ProtonPACS as well interpretation services. There is useful educational component within its site under the heading Clinic. Here, one can find interesting musculoskeletal cases posted on monthly basis. Each case synopsis includes brief history, review...
Musculoskeletal Radiology Signs: http://www.gentili.net/signs/ Description: Signs is an interactive atlas encompassing many of the common and uncommon signs encountered in musculoskeletal radiology. It authored by Drs. Gentili, Beller, Masih, Seeger, approved American Roentgen Ray Society. Searchable anatomic location, sign name, or condition, this includes X-ray, magnetic resonance imaging, computed tomography images demonstrating radiographic signs, diagnoses associated, a brief...