A5042621624- Ovarian function and disorders
- Reproductive Biology and Fertility
- RNA Research and Splicing
- RNA modifications and cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Thyroid Disorders and Treatments
- Pancreatitis Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Immune cells in cancer
- Sirtuins and Resveratrol in Medicine
- Telomeres, Telomerase, and Senescence
- Connective tissue disorders research
- Cancer, Hypoxia, and Metabolism
- Sperm and Testicular Function
- Growth Hormone and Insulin-like Growth Factors
Sichuan University
2024
State Key Laboratory of Oral Diseases
2024
University of South China
2021-2022
Scope Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder that can cause infertility; however, the underlying mechanisms remain ill‐defined, there are no available drugs or strategies for treatment of PCOS. This study examined therapeutic effect resveratrol in rat model Methods Results PCOS induced rats by administration letrozole high fat diet to determine whether has protective effect. Oral significantly decreased body weight, as well serum levels testosterone...
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovaries. In this study, we induced young-adult PCOS rat model oral administration of letrozole combined with high-fat diet then treated mogroside V (MV) to evaluate the protective effects MV on follicle development in rats. (600 mg/kg/day) not only significantly reduced body weight weight, but also attenuated disrupted estrous cycle decreased level...
Biological aging profoundly impairs the homeostasis of skeletal system. Cellular senescence, a hallmark biological aging, plays an instrumental role in bone disease. The underlying mechanisms cellular triggered by both intracellular and extracellular stimuli, are multifaceted yet to be uncovered. Recent research indicates that acute senescence often serves beneficial roles, such as contributing growth, development, tissue regeneration. By contrast, chronic primarily driven accumulation...