A5060124703- RNA Research and Splicing
- RNA modifications and cancer
- Neurotransmitter Receptor Influence on Behavior
- Cell Image Analysis Techniques
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Advanced Biosensing Techniques and Applications
- RNA and protein synthesis mechanisms
- Advanced Proteomics Techniques and Applications
- RNA regulation and disease
McGill University
2018-2020
Montreal Clinical Research Institute
2019
Protein-RNA interactions are essential for controlling most aspects of RNA metabolism, including synthesis, processing, trafficking, stability and degradation. In vitro selection methods, such as RNAcompete Bind-n-Seq, have defined the consensus target motifs hundreds RNA-binding proteins (RBPs). However, readily available information about distribution features these across full transcriptomes was hitherto lacking. Here, we introduce oRNAment (o enrichment in transcriptomes), a database...
Abstract We present the nELISA, a high-throughput, high-fidelity, and high-plex protein profiling platform. DNA oligonucleotides are used to pre-assemble antibody pairs on spectrally encoded microparticles perform displacement-mediated detection. Spatial separation between non-cognate antibodies prevents rise of reagent-driven cross-reactivity, while read-out is performed cost-efficiently at high-throughput using flow cytometry. assembled an inflammatory panel 191 targets that were...