A5042117543- Intracranial Aneurysms: Treatment and Complications
- Meningioma and schwannoma management
- Vascular Malformations Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Head and Neck Surgical Oncology
- Cerebrospinal fluid and hydrocephalus
- Cancer, Hypoxia, and Metabolism
- Neurosurgical Procedures and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Spinal Dysraphism and Malformations
- Ear Surgery and Otitis Media
- Advanced MRI Techniques and Applications
- Epilepsy research and treatment
- Facial Nerve Paralysis Treatment and Research
- Spinal Fractures and Fixation Techniques
- Cerebrovascular and Carotid Artery Diseases
- Epigenetics and DNA Methylation
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neurofibromatosis and Schwannoma Cases
- CAR-T cell therapy research
- Advanced Neuroimaging Techniques and Applications
- Bone Tumor Diagnosis and Treatments
University of Modena and Reggio Emilia
2001-2025
Azienda Sanitaria Unità Locale di Reggio Emilia
2023-2024
Azienda Unita' Sanitaria Locale Di Modena
2015-2024
De Agostini (Italy)
2014-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2023
National Operating Committee on Standards for Athletic Equipment
2016-2022
Istituto Oncologico Veneto
2016-2021
Policlinico di Modena
2017-2020
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
2018
University of Padua
2006-2016
Tumor targeting by genetically modified mesenchymal stromal/stem cells (MSCs) carrying anti-cancer molecules represents a promising cell-based strategy. We previously showed that the pro-apoptotic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can be successfully delivered MSCs to cancer sites. While interaction between TRAIL and its receptors is clear, more obscure way in which selectively target tumors their antigens. Several neuroectoderm-derived neoplasms,...
Abstract Glioblastoma is the most malignant primary brain tumor and still in need of effective medical treatment. We isolated patient-derived glioblastoma cells showing high GD2 antigen expression representing a potential target for CAR T strategy. Data highlighted robust antitumor 2D 3D models associated with significant T-restricted increase selected cytokines. Interestingly, immunosuppressant TGF β1, expressed all co-cultures, did not influence activity. The orthotopic NOD/SCID using...
OBJECTIVE The aim of this study was to describe the first case series in which an exclusive endoscopic transcanal transpromontorial approach (EETTA) used treat small vestibular schwannomas (VSs) and meningiomas internal auditory canal (IAC). METHODS authors performed a retrospective review patients who had undergone surgery using EETTA IAC at 2 university tertiary care referral centers during period from November 2011 January 2015. RESULTS Ten underwent via for treatment VS University...
Objectives To describe our departmental experience in the surgical repair of tegmen tympani defects using a combined transmastoid/minicraniotomic approach. Design Retrospective review videos from surgery and patients' charts. Setting Tertiary university referral center. Participants Twenty-two patients who underwent associated with cerebrospinal fluid (CSF) leakage and/or meningocele/meningoencephalocele by Main Outcome Measures A retrospective charts or antri CSF leakage, temporal lobe...
Abstract The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy, consistent with ILAE's mission. In patients drug‐resistant focal epilepsy who are candidates for surgical intervention, the identification structural abnormalities is a strong predictor favorable postoperative seizure outcomes. When conventional imaging insufficient, integration multimodal data structural, metabolic, and functional modalities often helpful....
The concurrence of intracranial aneurysms and acromegaly has been reported debated previously. Our study in a large number patients aimed to verify whether carry higher risk harboring saccular evaluate the possible relationship using clinical, laboratory, imaging techniques.A total 152 161 consecutive (median age, 55.7 yr; 82 females) underwent neuroimaging evaluation circle Willis. Clinical data (disease duration disease control, hypertension, smoking history, diabetes dyslipidemia,...
Although many studies have been published about specific lesions characterizing von Hippel-Lindau(VHL) disease, none dealt with the natural history of whole disease and consequent disabilities. We aim to define comprehensive VHL describe functional disabilities their impact upon patients' quality life, thereby tailoring follow-up schedule accordingly. performed a prospective analysis on 128 VHL-affected patients beginning in 1996. For each affected organ, we defined intervals between first...
Objectives/Hypothesis The aim of this study was to describe and evaluate the feasibility an expanded transcanal transpromontorial approach, developed from exclusive endoscopic approach. Study Design Retrospective case series. Methods chart review 10 patients operated by approach in two tertiary referral centers (University Hospital Modena, Italy University Verona, Italy). Data charts video documentation were collected analyzed. Results Between April 2015 January 2016, underwent for...
Introduction: Awake craniotomy allows continuous monitoring of patients' neurological functions during open surgery. Anesthesiologists have to sedate patients in a way so that they are compliant throughout the whole surgical procedure, nevertheless maintaining adequate analgesia and anxiolysis. Currently, use α2-receptor agonist dexmedetomidine as primary hypnotic–sedative medication is increasing. Methods: Nine undergoing awake were treated with refined monitored anesthesia care (MAC)...
Abstract Glioblastoma (GBM) remains a deadly tumor. Treatment with chemo-radiotherapy and corticosteroids is known to impair the functionality of lymphocytes, potentially compromising development autologous CAR T cell therapies. We here generated pre-clinical investigations anti-GD2 cells tested against 2D 3D models GBM primary cells. detected robust antitumor effect, highlighting feasibility developing an cell-based therapy for patients.
A blood blister-like (BBL) or dissecting aneurysm should be carefully considered if located at a non-branching site of the supra-clinoid internal carotid artery (ICA). Several surgical and endovascular treatment methods have been proposed but they all carry relatively high risk morbidity mortality. This study evaluated effectiveness novel Silk flow-diverting device (SFD) placed in early acute stage. Three patients presenting with subarachnoid haemorrhage caused by small blisterlike aneurysms...
The impact of COVID-19 outbreak in the neurosurgical practice has been dramatic, imposing several limitations. aim this study is to present how departments Emilia-Romagna, a northern Italian region, have re-set their organization maintain higher standard care as possible.All operative room and outpatient activities performed during emergency department Emilia-Romagna collected compared means same timeframe 2018 2019.In 2020, 205 surgical procedures 466 consultations performed, representing...
Endoscopic ear surgery is radically changing the treatment of several middle and inner pathology, but its learning presents well-known manual technical difficulties. The aim this paper be to present a training programme based on modular model increased experience from 2007 2016 at University Hospital Modena Verona was reviewed analysed for further considerations establish stages training. increasing expert surgeons who deal with kind represented main guide steps progression In addition,...