A5000898003- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Voice and Speech Disorders
- Transcranial Magnetic Stimulation Studies
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Neurogenetic and Muscular Disorders Research
- Glycogen Storage Diseases and Myoclonus
- Alzheimer's disease research and treatments
- Lysosomal Storage Disorders Research
- Long-Term Effects of COVID-19
- Balance, Gait, and Falls Prevention
- Cellular transport and secretion
- Eosinophilic Disorders and Syndromes
- Cholesterol and Lipid Metabolism
- Hereditary Neurological Disorders
- Muscle and Compartmental Disorders
- Amyotrophic Lateral Sclerosis Research
- Cerebral Palsy and Movement Disorders
- Vestibular and auditory disorders
- Neuroscience and Neuropharmacology Research
- Organoboron and organosilicon chemistry
- Advanced Neuroimaging Techniques and Applications
Azienda Sanitaria Unità Locale di Reggio Emilia
2022-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2025
University of Modena and Reggio Emilia
2021-2025
Azienda Ospedaliero-Universitaria di Modena
2023-2024
Azienda Unita' Sanitaria Locale Di Modena
2023
National Operating Committee on Standards for Athletic Equipment
2023
Motion Control (United States)
2023
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Deletions of the short arm chromosome 18 encompassing GNAL gene are associated with 18p deletion syndrome, whose clinical features include facial dysmorphism, stature, mental retardation, and movement disorders, especially dystonia 1 .Heterozygous loss-of-function variants known to cause adult-onset cranio-cervical and/or asymmetric dystonic tremor 2 .GNAL-related (DYT-GNAL) display an autosomal dominant (AD) inheritance pattern incomplete penetrance variable phenotypic expressivity.Only a...
Neurosteroids are pleiotropic molecules involved in various neurodegenerative diseases with neuroinflammation. We assessed neurosteroids serum levels a cohort of Parkinson’s Disease (PD) patients heterozygous glucocerebrosidase (GBA) mutations (GBA-PD) compared matched cohorts consecutive non-mutated PD (NM-PD) patients, and healthy subjects (GBA-C) without (NM-HC) GBA mutations. A GBA-PD was paired for age, sex, disease duration, Hoehn & Yahr stage, comorbidities...
(1) Background: Cerebellar ataxia with neuropathy and vestibular areflexia syndrome (CANVAS) is characterized by late-onset cerebellar ataxia, bilateral vestibulopathy, sensory neuronopathy mostly due to biallelic RFC1 expansion. (2) Objectives: The aim of this case series describe vestibular, gait, speech alterations in CANVAS via a systematic approach. (3) Methods: All patients (n = 5) underwent standardized clinical-instrumental examination, including the perceptual acoustic analysis...
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson’s Disease (PD). However, the effects of STN-DBS on freezing gait (FOG) are still debated, particularly long-term follow-up (≥5-years). The main aim current study to evaluate FOG. Twenty treated PD patients were included. Each patient was assessed before surgery through a detailed neurological evaluation, including FOG score, and revaluated (median follow-up: 5-years) different drug...
Very few studies have assessed the presence of a possible correlation between speech variables and limb bradykinesia in patients with Parkinson's disease (PD). The objective this study was to find correlations different upper extremity under medication conditions advanced PD patients.Retrospective data were collected from cohort before after an acute levodopa challenge. Each patient perceptual-acoustic analysis speech, which included several quantitative parameters [i.e., maximum phonation...
Neurosteroids are pleiotropic molecules involved in various neurodegenerative diseases with neuroinflammation. We assessed neurosteroids' serum levels a cohort of Parkinson's Disease (PD) patients heterozygous glucocerebrosidase (GBA) mutations (GBA-PD) compared matched cohorts consecutive non-mutated PD (NM-PD) and healthy subjects (GBA-HC) without (NM-HC) GBA mutations. A GBA-PD was paired for age, sex, disease duration, Hoehn Yahr stage, comorbidities NM-PD. Two GBA-HC HC were also...
Abstract Objective To evaluate correlations between speech and gait parameters in the long term under different medication subthalamic nucleus deep brain stimulation (STN‐DBS) conditions a cohort of advanced Parkinson's disease (PD) patients. Methods This observational study included consecutive PD patients treated with bilateral STN‐DBS. Axial symptoms were evaluated using standardized clinical‐instrumental approach. Speech assessed by perceptual acoustic analyses instrumented Timed Up Go...
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson's Disease (PD). However, the effects of STN-DBS on speech are still debated, particularly long-term follow-up. The objective this study was to evaluate bilateral a cohort PD patients treated with STN-DBS. Each patient assessed before surgery through neurological evaluation and perceptual-acoustic analysis re-assessed different drug conditions. primary outcome percentage change...
Severe non-infectious or non-haemorrhagic brain edema surrounding the electrode represents a rare complication of subthalamic nucleus deep stimulation (STN-DBS) surgery. The aim this study is to report three patients with advanced Parkinson’s Disease (PD) who developed symptomatic after STN-DBS surgery treated intravenous steroids specific profile reversible cognitive alterations. Patients were both assessed comprehensive neuropsychological battery including attention, memory, visuo-spatial...
Objectives: To evaluate the possible long-term cerebral deposition of amyloid-β in PD patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) and its influence on axial cognitive variables. Methods: Consecutive bilateral STN-DBS a follow-up were included. Amyloid-β was evaluated postoperatively through 18F-flutemetamol positron emission tomography (PET) study. Axial symptoms have been assessed using standardized clinical-instrumental approach. Speech by perceptual acoustic...