A5074323488- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- Nanoporous metals and alloys
- Distributed and Parallel Computing Systems
- Muscle activation and electromyography studies
- Scientific Computing and Data Management
- Advanced Data Storage Technologies
- Electrocatalysts for Energy Conversion
- Advanced Memory and Neural Computing
- EEG and Brain-Computer Interfaces
- Electrical and Bioimpedance Tomography
- Anodic Oxide Films and Nanostructures
- Cloud Computing and Resource Management
- Service-Oriented Architecture and Web Services
- Graphene research and applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Fullerene Chemistry and Applications
- Dielectric materials and actuators
- Caching and Content Delivery
- Neural dynamics and brain function
- 3D Printing in Biomedical Research
- Cloud Computing and Remote Desktop Technologies
- Personal Information Management and User Behavior
- Advanced Polymer Synthesis and Characterization
Queen Mary University of London
2023-2025
Imperial College London
2019-2024
University of Connecticut
2024
UNSW Sydney
2024
University College London
2005-2021
University of California, Davis
2013-2017
University of America
2004-2013
Catholic University of America
2004-2013
Office of Scientific and Technical Information
2010
National Technical Information Service
2010
Designing neural interfaces that maintain close physical coupling of neurons to an electrode surface remains a major challenge for both implantable and in vitro recording arrays. Typically, low-impedance nanostructured coatings rely on chemical cues from pharmaceuticals or surface-immobilized peptides suppress glial scar tissue formation over the (astrogliosis), which is obstacle reliable neuron–electrode coupling. Nanoporous gold (np-Au), produced by alloy corrosion process, promising...
Nanostructured neural interface coatings have significantly enhanced recording fidelity in both implantable and vitro devices. As such, nanoporous gold (np-Au) has shown promise as a multifunctional coating due, part, to its ability promote nanostructure-mediated reduction astrocytic surface coverage while not affecting neuronal coverage. The goal of this study is provide insight into the mechanisms by which np-Au nanostructure drives differential response neurons versus astrocytes an model....
Localized and actively controlled delivery of drugs presents an opportunity for improving bioavailability, therapeutic efficacy, long-term treatment injury or disease. Conductive polymer (CP) based systems present a unique using inherent electrochemical actuating properties to ensure that are delivered retained charge mechanisms. A number CP formats have been explored spanning films, composites CPs with polymeric carriers, organic electronic ion pumps (OEIPs). Each these designs can be used...
Abstract There is a critical need to transition research level flexible polymer bioelectronics toward the clinic by demonstrating both reliability in fabrication and stable device performance. Conductive elastomers (CEs) are composites of conductive polymers elastomeric matrices that provide flexibility enhanced electrochemical properties compared conventional metallic electrodes. This work focuses on development nerve cuff devices assessment functionality at each stage, from CE material...
Aligning the material properties of organic semiconducting polymers to effectively interface with biological matter is critical for their use in bioelectronic devices. Synthetic modification and advanced processing techniques have typically been employed promote cell adhesion growth. In this study we apply UV-Ozone (UVO) treatment as a simple accessible alternative modifying pDPP3T films. Exposure UVO increases polarity semiconductor surface, confirmed by contact angle XPS analysis. Surface...
Non-invasive imaging techniques are undoubtedly the ideal methods for continuous monitoring of neural activity. One such method, fast electrical impedance tomography (EIT) has been developed over past decade in order to image action potentials with non-penetrating electrode arrays.The goal this study is two-fold. First, we present a detailed fabrication method silicone-based multiple arrays which can be used epicortical or cuff applications. Secondly, optimize material coatings achieve best...
Abstract Microfabrication and nanotechnology have significantly expanded the technological capabilities for monitoring modulating neural activity with goal of studying nervous system managing neurological disorders. This feature article initially provides a tutorial‐like review prominent technologies enabling this two‐way communication via electrical, chemical, optical means. Following overview, discusses emerging high‐throughput methods identifying device attributes that enhance...
Photothermal treatment of nanoporous gold thin films enables fabrication patterned on-chip material libraries for use in parallel structure–property relationship studies.
Abstract This paper describes a prototype grid infrastructure, called the “eMinerals minigrid”, for molecular simulation scientists. which is based on an integration of shared compute and data resources. We describe key components, namely use Condor pools, Linux/Unix clusters with PBS IBM's LoadLeveller job handling tools, Globus security handling, Condor-G tools wrapping globus submit commands, Condor's DAGman tool workflow, Storage Resource Broker data, CCLRC dataportal associated both...
Nanostructured materials with feature sizes in tens of nanometers have enhanced the performance several technologies, including fuel cells, biosensors, biomedical device coatings, and drug delivery tools. Nanoporous gold (np-Au), produced by a nano-scale self-assembly process, is relatively new material that exhibits large effective surface area, high electrical conductivity, catalytic activity. These properties made np-Au an attractive to scientific community. Most studies on employ...
Conductive polymer (CP)–elastomer composites have been proposed as an alternative to the metals conventionally used for bioelectronic devices. Being softer and more stretchable than such platinum gold, they can mitigate adverse effects associated with mechanical mismatch fatigue failure. Such are made by embedding CP particles inside elastomeric matrix. However, achieve a structure, high loading that reaches percolation threshold is required. High thresholds lead degradation of properties....
On-
Conventional wet Ag/AgCl electrodes are widely used in electrocardiography, electromyography (EMG), and electroencephalography (EEG) considered the gold standard for biopotential measurements. However, these require substantial skin preparation, single use, cannot be continuous monitoring (>24 h). For reasons, dry preferable during surface (sEMG) due to their convenience, durability, longevity. Dry conductive elastomers (CEs) combine conductivity, flexibility, stretchability. In this study,...
Quantitative analysis of fluorescence signals from cells reacted with fluorescently labeled probes is a widely-used method for assessing cell biology. This has become especially powerful screening novel nanostructured materials their influence on behavior. However, the effect surface intensity largely been ignored, which likely leads to erroneous conclusions about paper investigates this possibility by using fibroblasts cultured nanoporous gold (np-Au) as model material system. We found that...