A5009901504- Neuroscience and Neural Engineering
- Conducting polymers and applications
- Advanced Sensor and Energy Harvesting Materials
- EEG and Brain-Computer Interfaces
- 3D Printing in Biomedical Research
- Muscle activation and electromyography studies
- Advanced Memory and Neural Computing
- Photoreceptor and optogenetics research
- Hydrogels: synthesis, properties, applications
- Nerve injury and regeneration
- Electrospun Nanofibers in Biomedical Applications
- Analytical Chemistry and Sensors
- Electrochemical sensors and biosensors
- Organic Electronics and Photovoltaics
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Neurological disorders and treatments
- Acoustic Wave Resonator Technologies
- Neural dynamics and brain function
- Dielectric materials and actuators
- Planarian Biology and Electrostimulation
- Graphene and Nanomaterials Applications
- Supramolecular Self-Assembly in Materials
- Diabetes Management and Research
- Neuroinflammation and Neurodegeneration Mechanisms
Imperial College London
2017-2025
UNSW Sydney
2011-2024
Queen Mary University of London
2024
Northeastern University
2022
First Affiliated Hospital of Jinan University
2022
Tsinghua University
2022
State Key Laboratory of New Ceramics and Fine Processing
2022
The University of Melbourne
2022
Cochlear (Australia)
2020
Macquarie University
2020
Abstract A hybrid system for producing conducting polymers within a doping hydrogel mesh is presented. These conductive hydrogels demonstrate comparable electroactivity to conventional without requiring the need mobile ions which are typically used in literature. hybrids have superior mechanical stability and modulus significantly closer neural tissue than materials commonly medical electrodes. Additionally they shown support attachment differentiation of like cells, with improved...
Objective. Recent interest in the use of conducting polymers (CPs) for neural stimulation electrodes has been growing; however, concerns remain regarding stability coatings under conditions. These studies examine factors CP and implant environment that affect coating stability. The poly(ethylene dioxythiophene) (PEDOT) is examined comparison to platinum (Pt), demonstrate potential performance these neuroprosthetic applications. Approach. PEDOT coated on Pt microelectrode arrays assessed...
Conducting hydrogels (CHs) are an emerging technology in the field of medical electrodes and brain-machine interfaces. The greatest challenge to fabrication CH is hybridization dissimilar polymers (conductive polymer hydrogel) ensure formation interpenetrating networks (IPN) required achieve both soft electroactive materials. A new hydrogel system developed that enables tailored placement covalently immobilized dopant groups within matrix. role investigated through covalent linking sulfonate...
Abstract Conducting polymers have often been described in literature as a coating for metal electrodes which will dampen the mechanical mismatch with neural tissue, encouraging intimate cell interactions. However, there is very limited quantitative analysis of conducting polymer mechanics and relation to tissue This article systematically analyses impact platinum (Pt) poly(ethylene dioxythiophene) (PEDOT) doped series common anions explored interfacing applications. Nanoindentation was used...
Soft, flexible and stretchable conductive elastomers made of polyurethane PEDOT:PSS blends were fabricated into fully polymeric implantable bioelectrode arrays.
Abstract Existing bionic implants use metal electrodes, which have low charge transfer capacity and poor tissue integration. This limits their in next‐generation, high resolution devices. Coating other modification techniques been explored to improve the performance of electrodes. While this has enabled increased properties integration biologically responsive components, stable long term remains a significant challenge. progress report provides background on electrode techniques, exploring...
Conductive hydrogel (CH) coatings for biomedical electrodes have shown considerable promise in improving electrode mechanical and charge transfer properties. While they desirable properties as a bulk material, there is limited understanding of how these translate to microelectrode array. This study evaluated the performance CH applied Nucleus Contour Advance cochlear arrays. Cyclic voltammetry biphasic stimulation were carried out determine electrical coated Electrical testing demonstrated...
Hydrogels have been applied across a wide range of biomedical applications due to their versatility, but more recently garnered interest as materials in bioelectronics the capacity tailor mechanical and biological properties. Hydrogel coatings particular used impart softness at bionic device interface, deliver therapeutics control cell interactions through presentation peptides growth factors. Additionally, use dynamic hydrogel properties has harnessed shuttles for implantation flexible...
Localized and actively controlled delivery of drugs presents an opportunity for improving bioavailability, therapeutic efficacy, long-term treatment injury or disease. Conductive polymer (CP) based systems present a unique using inherent electrochemical actuating properties to ensure that are delivered retained charge mechanisms. A number CP formats have been explored spanning films, composites CPs with polymeric carriers, organic electronic ion pumps (OEIPs). Each these designs can be used...
Abstract There is a critical need to transition research level flexible polymer bioelectronics toward the clinic by demonstrating both reliability in fabrication and stable device performance. Conductive elastomers (CEs) are composites of conductive polymers elastomeric matrices that provide flexibility enhanced electrochemical properties compared conventional metallic electrodes. This work focuses on development nerve cuff devices assessment functionality at each stage, from CE material...
Objective. Laser surface modification of platinum (Pt) electrodes was investigated for use in neuroprosthetics. Surface applied to increase the area electrode and improve its ability transfer charge within safe electrochemical stimulation limits. Approach. Electrode arrays were laser micromachined produce Pt with smooth surfaces, which then modified four patterning techniques structures nanosecond patterned, square profile, triangular profile roughened on micron scale through structured...
Objective. Evaluate electrochemical properties, biological response, and surface characterization of a conductive hydrogel (CH) coating following chronic in vivo stimulation. Approach. Coated CH or uncoated smooth platinum (Pt) electrode arrays were implanted into the cochlea rats stimulated over 5 week period with more than 57 million biphasic current pulses. Electrochemical impedance spectroscopy (EIS), charge storage capacity (CSC), injection limit (CIL), voltage transient (VT) measured...